IE33453L - Thiadiazole derivatives - Google Patents

Abstract

(1) Compds. (I) their salts and optical isomers where R = H; halogen; 1-5C-alkyl; 2-5C alkenyl; a group Y-X-Z-, where Y = 1-4C alkyl opt. substd. by Ph or Ph- substd. by halogen, OH, 1-3C alkyl or 1-3C alkoxy, X = O or S and Z is methyl or ethyl(sic); R5NHCO where R5 = 1-5C alkyl; 3-6C cycloalkyl; 1-5C alkoxy; Ph, opt. substd. by halogen, 1-3C alkyl, 1-3C alkoxy; Ph-(1-4C alkyl)- opt. substd. in Ph by halogen, 1-3C alkyl, 1-3C alkoxy; NR7R8 where R7 = H, 1-4C alkyl or 2-4C-hydroxy-alkyl, and R8 = H, 1-4C alkyl, 2-4C hydroxy alkyl or Ph opt. substd. by OH or NR7R8 is a 3-7 membered heterocyclic ring opt. substd. by 1-5C alkyl or 1-3C-hydroxyalkyl or a 5- or 6-membered ring contng. additional O or S or N atoms and opt. substd. by 1-3C alkyl groups, or a 5- or 6-membered N- or O-contng. heterocyclic ring; R1 = H or 1-3C alkyl; R2 = H or 1-3C alkyl; R3 = H, PhCO or 2-4C-alkanoyl; R4 = H or 1-3C alkyl; R5 = H or 1-5C alkyl, phenyl-(1-3C)-alkyl or 1-5C alkanoyl; R6 = 1-20C alkyl (esp. 3-6C) or 2-6C alkenyl or alkynyl opt. substd. by OH, halogen, carboxy, carboxylic ester 1-4C alkoxy, 1-4C alkylthio, di-(1-3C) alkylamino or a N-contng. heterocyclic ring opt. contng. other N, O or S atoms and where N-atoms are opt. attached to 1-8C alkyl groups, Ph or PhO opt. substd. by 1-3 OH, 1-3C-alkoxy. A O, N or S-contng. heterocycle linked through a ring C-atom; Ph opt. substd. by 1-3C alkyl or 5-6 membered heterocyclic ring; 3-6C cycloalkyl opt. substd. by 1-3C alkyl or 5-6 membered O- or N-contng. heterocycle; a 5 or 6-membered heterocyclic ring contng. O, N or S, linked through a ring C atom and opt. substd. by 1-3C alkyl or 5 or 6-membered N or O-contng. heterocyclic ring or R5 and R6 may be linked together with the adjacent N-atom to form a 4-6 membered ring opt. substd. by 1-3C alkyl and opt. contng. additional O, N or S atoms. (2) Medicaments contng. (II). beta-Adrenergic agents. [CH543536A]