IE33906B1 - Pyrrolobenzodiazepinone derivatives - Google Patents

Pyrrolobenzodiazepinone derivatives

Info

Publication number: IE33906B1
Authority: IE; Ireland
Prior art keywords: pyrrolobenzodiazepinone; derivatives; pyrrolobenzodiazepinone derivatives
Prior art date: 1968-12-30

Application number

IE1726/69A

Other languages

English (en)

Other versions

IE33906L (en

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1968-12-30

Filing date

1969-12-30

Publication date

1974-12-11

1969-06-26 Priority claimed from JP44050780A external-priority patent/JPS4843755B1/ja

1969-12-30 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1970-06-30 Publication of IE33906L publication Critical patent/IE33906L/xx

1974-12-11 Publication of IE33906B1 publication Critical patent/IE33906B1/xx

Links

VRQOSIAJWZNUSL-UHFFFAOYSA-N 2h-pyrrolo[2,3-i][1,2]benzodiazepin-3-one Chemical class C12=NNC(=O)C=CC2=CC=C2C1=CC=N2 VRQOSIAJWZNUSL-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IE1726/69A 1968-12-30 1969-12-30 Pyrrolobenzodiazepinone derivatives IE33906B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP8368		1968-12-30
JP44050780A JPS4843755B1 (2)	1969-06-26	1969-06-26

Publications (2)

Publication Number	Publication Date
IE33906L IE33906L (en)	1970-06-30
IE33906B1 true IE33906B1 (en)	1974-12-11

Family

ID=26332992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE1726/69A IE33906B1 (en)	1968-12-30	1969-12-30	Pyrrolobenzodiazepinone derivatives

Country Status (6)

Country	Link
ES (1)	ES375013A1 (2)
FI (1)	FI46259C (2)
GB (1)	GB1299198A (2)
IE (1)	IE33906B1 (2)
IL (1)	IL33558A (2)
RO (1)	RO55813A (2)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4464467A (en) *	1982-07-26	1984-08-07	Bristol-Myers Company	Antitumor antibiotics produced by new streptomyces
GB9818732D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Collection of compounds
DE69930328T2 (de) *	1998-08-27	2006-12-14	Spirogen Ltd., Ryde	Dimere Pyrrolobenzodiazepine
GB9818730D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Collections of compounds
US6909006B1 (en)	1999-08-27	2005-06-21	Spirogen Limited	Cyclopropylindole derivatives
GB0226593D0 (en)	2002-11-14	2002-12-24	Consultants Ltd	Compounds
GB0321295D0 (en)	2003-09-11	2003-10-15	Spirogen Ltd	Synthesis of protected pyrrolobenzodiazepines
SI2270010T1 (sl)	2004-03-01	2012-05-31	Spirogen Ltd	hidroksi H pirolo c benzodiazepin onski derivati kot ključni intermediati za pripravo C substituiranih pirolobenzodiazepinov
GB0404577D0 (en)	2004-03-01	2004-04-07	Spirogen Ltd	Pyrrolobenzodiazepines
JP5166861B2 (ja)	2004-03-09	2013-03-21	スピロゲンリミティッド	ピロロベンゾジアゼピン
GB0819095D0 (en)	2008-10-17	2008-11-26	Spirogen Ltd	Pyrrolobenzodiazepines
MX391454B (es)	2010-04-15	2025-03-05	Seagen Inc	Compuesto de engarce-fármaco para conjugación a una unidad de ligando.
GB201006340D0 (en)	2010-04-15	2010-06-02	Spirogen Ltd	Synthesis method and intermediates
US8697688B2 (en)	2010-04-15	2014-04-15	Seattle Genetics Inc.	Pyrrolobenzodiazepines used to treat proliferative diseases
JP6170494B2 (ja)	2011-09-20	2017-07-26	メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅＬｉｍｉｔｅｄ	ピロロベンゾジアゼピン
CA2850096C (en)	2011-10-14	2018-07-03	Spirogen Sarl	Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
ES2945932T3 (es)	2011-10-14	2023-07-10	Seagen Inc	Pirrolobenzodiazepinas y conjugados dirigidos
CA2850103C (en)	2011-10-14	2019-09-10	Spirogen Sarl	Pyrrolobenzodiazepines
WO2013055993A1 (en)	2011-10-14	2013-04-18	Seattle Genetics, Inc.	Pyrrolobenzodiazepines and targeted conjugates
CN103998449A (zh)	2011-10-14	2014-08-20	斯皮罗根有限公司	吡咯并苯并二氮杂卓
AU2013328674B2 (en)	2012-10-12	2017-06-22	Medimmune Limited	Pyrrolobenzodiazepines and conjugates thereof
EP2906250B1 (en)	2012-10-12	2018-05-30	ADC Therapeutics SA	Pyrrolobenzodiazepine-anti-psma antibody conjugates
EP2906249B1 (en)	2012-10-12	2018-06-27	MedImmune Limited	Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
CN104837502B (zh)	2012-10-12	2018-08-10	麦迪穆有限责任公司	吡咯并苯并二氮杂卓及其结合物
US10751346B2 (en)	2012-10-12	2020-08-25	Medimmune Limited	Pyrrolobenzodiazepine—anti-PSMA antibody conjugates
US10695433B2 (en)	2012-10-12	2020-06-30	Medimmune Limited	Pyrrolobenzodiazepine-antibody conjugates
DK2906298T3 (en)	2012-10-12	2018-12-17	Adc Therapeutics Sa	Pyrrolobenzodiazepine-antibody conjugates
AU2013328625B2 (en)	2012-10-12	2016-12-15	Adc Therapeutics Sa	Pyrrolobenzodiazepine-antibody conjugates
ES2649990T3 (es)	2012-10-12	2018-01-16	Medimmune Limited	Conjugados de anticuerpos anti-CD22-pirrolobenzodiazepinas
GB201317981D0 (en)	2013-10-11	2013-11-27	Spirogen Sarl	Pyrrolobenzodiazepines and conjugates thereof
EP3054985B1 (en)	2013-10-11	2018-12-26	Medimmune Limited	Pyrrolobenzodiazepine-antibody conjugates
US10010624B2 (en)	2013-10-11	2018-07-03	Medimmune Limited	Pyrrolobenzodiazepine-antibody conjugates
EP3054986B1 (en)	2013-10-11	2019-03-20	Medimmune Limited	Pyrrolobenzodiazepine-antibody conjugates
GB201416112D0 (en)	2014-09-12	2014-10-29	Medimmune Ltd	Pyrrolobenzodiazepines and conjugates thereof
AU2015352545B2 (en)	2014-11-25	2020-10-15	Adc Therapeutics Sa	Pyrrolobenzodiazepine-antibody conjugates
GB201506402D0 (en)	2015-04-15	2015-05-27	Berkel Patricius H C Van And Howard Philip W	Site-specific antibody-drug conjugates
GB201506411D0 (en)	2015-04-15	2015-05-27	Bergenbio As	Humanized anti-axl antibodies
GB201601431D0 (en)	2016-01-26	2016-03-09	Medimmune Ltd	Pyrrolobenzodiazepines
GB201602359D0 (en)	2016-02-10	2016-03-23	Medimmune Ltd	Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en)	2016-02-10	2016-03-23	Medimmune Ltd	Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en)	2016-04-29	2016-06-15	Medimmune Ltd	Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en)	2016-10-14	2016-11-30	Medimmune Ltd	Pyrrolobenzodiazepine conjugates
MX375569B (es)	2017-02-08	2025-03-04	Adc Therapeutics Sa	Conjugados de pirrolobenzodiazepinas y anticuerpos
GB201702031D0 (en)	2017-02-08	2017-03-22	Medlmmune Ltd	Pyrrolobenzodiazepine-antibody conjugates
PT3612537T (pt)	2017-04-18	2022-08-29	Medimmune Ltd	Conjugados de pirrolobenzodiazepina
ES2977788T3 (es)	2017-04-20	2024-08-30	Adc Therapeutics Sa	Terapia combinada con un conjugado de anticuerpo anti-AXL y fármaco
MX2019015042A (es)	2017-06-14	2020-08-06	Adc Therapeutics Sa	Regimen de dosificacion.
DK3668874T3 (da)	2017-08-18	2022-02-14	Medimmune Ltd	Pyrrolobenzodiazepin-konjugater
GB201803342D0 (en)	2018-03-01	2018-04-18	Medimmune Ltd	Methods
GB201806022D0 (en)	2018-04-12	2018-05-30	Medimmune Ltd	Pyrrolobenzodiazepines and conjugates thereof
KR102890251B1 (ko)	2019-03-15	2025-11-25	메드임뮨 리미티드	암의 치료에 사용하기 위한 아제티도벤조디아제핀 이량체 및 이를 포함하는 컨쥬게이트

1969
- 1969-12-17 IL IL33558A patent/IL33558A/xx unknown
- 1969-12-22 FI FI693710A patent/FI46259C/fi active
- 1969-12-24 GB GB62863/69A patent/GB1299198A/en not_active Expired
- 1969-12-29 ES ES375013A patent/ES375013A1/es not_active Expired
- 1969-12-30 IE IE1726/69A patent/IE33906B1/xx unknown
- 1969-12-30 RO RO62025A patent/RO55813A/ro unknown

Also Published As

Publication number	Publication date
IL33558A0 (en)	1970-04-20
IL33558A (en)	1973-10-25
IE33906L (en)	1970-06-30
FI46259C (fi)	1973-02-12
RO55813A (2)	1974-02-01
GB1299198A (en)	1972-12-06
ES375013A1 (es)	1972-03-01
FI46259B (2)	1972-10-31

Publication	Publication Date	Title
IE33906B1 (en)	1974-12-11	Pyrrolobenzodiazepinone derivatives
MY7500209A (en)	1975-12-31	Pyridobenzo-diazepine derivatives
CY780A (en)	1975-03-01	Bromo-ergocryptine
YU176068A (en)	1974-04-30	Farmaceutska kapsula
YU241169A (en)	1974-02-28	Diferencialni ojacevalnik
CY771A (en)	1974-11-11	N-tritylimidazole
IL32640A (en)	1975-06-25	3-carbamoylphenoxy-1-amino-2-propanol derivatives
IL32786A (en)	1973-02-28	N-phenylsuccinimide derivatives
YU32029B (en)	1974-02-28	Elektricni klozet
YU32647B (en)	1975-04-30	Lamelasta frikciona spojnica
IL32493A0 (en)	1969-08-27	Imidazolidino-quinazolines
IE32701L (en)	1969-08-10	Pyridazones-herbicides
CY728A (en)	1974-03-07	Omega-cyanoalkylcarbamylbenzimidazoles
YU153769A (en)	1973-10-31	Elektricni postavni uredaj
MY7400293A (en)	1974-12-31	Ergolene derivatives
YU31609B (en)	1973-08-31	Fluidno elasticna zaptivna caura
YU214169A (en)	1973-04-30	Motocikl
MY7400140A (en)	1974-12-31	Oxazinobenzodiazepine derivatives
ZA694133B (en)	1971-01-27	Aryloxyalkylguanidines
IE32652L (en)	1969-08-24	18-methyl-5ó-h-androstanes
MTP570B (en)	1971-09-09	Tetracyclipes derivatives
IL32760A0 (en)	1969-11-12	5-nitro-imidazole derivatives
IE32671L (en)	1973-09-14	p-AMINOALKYL-BENZENESULFONAMIDE DERIVATIVES
CA30192S (en)	1968-01-08	Bed-sofa
YU31748B (en)	1973-10-31	Locilnik sinhronizacijskih impulzov v televizijskem sprejmniku