IE35077L - Polypeptides - Google Patents
PolypeptidesInfo
- Publication number
- IE35077L IE35077L IE700709A IE70970A IE35077L IE 35077 L IE35077 L IE 35077L IE 700709 A IE700709 A IE 700709A IE 70970 A IE70970 A IE 70970A IE 35077 L IE35077 L IE 35077L
- Authority
- IE
- Ireland
- Prior art keywords
- thr
- leu
- ser
- boc
- gly
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108010015792 glycyllysine Proteins 0.000 abstract 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 6
- 108010071635 tyrosyl-prolyl-arginine Proteins 0.000 abstract 5
- 108010061238 threonyl-glycine Proteins 0.000 abstract 4
- 108010020532 tyrosyl-proline Proteins 0.000 abstract 4
- 108010036320 valylleucine Proteins 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010089804 glycyl-threonine Proteins 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 2
- VVQIIIAZJXTLRE-QMMMGPOBSA-N (2s)-2-amino-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound CC(C)(C)OC(=O)NCCCC[C@H](N)C(O)=O VVQIIIAZJXTLRE-QMMMGPOBSA-N 0.000 abstract 1
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- NSTPXGARCQOSAU-VIFPVBQESA-N N-formyl-L-phenylalanine Chemical compound O=CN[C@H](C(=O)O)CC1=CC=CC=C1 NSTPXGARCQOSAU-VIFPVBQESA-N 0.000 abstract 1
- DIHPMRTXPYMDJZ-KAOXEZKKSA-N Thr-Tyr-Pro Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2CCC[C@@H]2C(=O)O)N)O DIHPMRTXPYMDJZ-KAOXEZKKSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- OFJLSOXXIMLDDL-UHFFFAOYSA-N ethyl (4-nitrophenyl) carbonate Chemical compound CCOC(=O)OC1=CC=C([N+]([O-])=O)C=C1 OFJLSOXXIMLDDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- HGYBXODOMJPMNO-WCCKRBBISA-N methyl (2s)-2,5-diamino-5-oxopentanoate;hydrochloride Chemical compound Cl.COC(=O)[C@@H](N)CCC(N)=O HGYBXODOMJPMNO-WCCKRBBISA-N 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- -1 pivalic acid p-nitrophenyl ester Chemical class 0.000 abstract 1
- 108010004914 prolylarginine Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1314051 Polypeptides SANDOZ Ltd 22 May 1970 [3 June 1969 20 June 1969 (4) 23 June 1969 (3) 26 June 1969 30 June 1969 9 Sept 1969] 24779/70 Heading C2C Novel compounds I: S - CH 2 - CHX - CO - ser - asn - leu - ser - thr - cys - val - leu - gly - lys - leu - ser - gln - glu - leu - hislys - leu - gln - thr - tyr - pro - arg - thr - asnthr-gly-ser-gly-thr-Y wherein X is H, NH 2 , RCONH or R<SP>1</SP>OCONH; R is alkyl or optionally substituted aryl or aralkyl; R<SP>1</SP> is alkyl, alkenyl or optionally substituted aryl or aralkyl; and Y is -pro-NH 2 or -pro-val-NH 2 ; wherein the terminal peptide unit -S-CH 2 -CHX-CO- has the L-configuration where X is NH 2 , RCONH or R<SP>1</SP>OCONH; and wherein ser may be exchanged for thr or ala; asn for asp, gln or glu; thr for ser or ala; lys for lys(BOC), orn; asn or asp; glu for glu(OtBn), gln, asn or asp; leu for tyr; tyr for phe and arg for orn or lys, provided that when sequence is asin I, and Y is -pro-NH 2 , X is other than NH 2 , are prepared by normal methods of peptide synthesis. Intermediates isolated are Z- or H-thr-pro- NH 2 .HCl; Z-ser-gly-(OEt or NHNH 2 ); Z- or H - ser - gly - thr - pro - NH 2 ; Z - asn - thr - gly- OEt; Z - thr - asn - thr - gly - OEt; BOC- arg(NO 2 ) -thr - asn - thr - gly - (OEt or NHNH 2 ); (BOC or H) - arg - thr - asn - thr - gly - ser - glythr - pro - NH 2 ; (Z- or H-) thr - tyr - pro - (OH or OMe); Z-leu-gln-OMe; H-gln-OMe.HCl; Z- lys(BOC) - leu - gln - OMe: Z - his - lys(BOC)- leu - gln - (OMe or NHNH 2 ); Z - his - lys(BOC)- leu - gln - thr - tyr - pro - OH; Z - gln - thr - tyrpro - OH; Z - lys(BOC) - tyr(OMe); Z - hislys(BOC) - tyr - NHNH 2 ; Z - his - lys(BOC)- tyr - gln - thr - tyr - pro - OH; (Z or H) - hislys(BOC) - leu - gln - thr - tyr - pro - arg - thrasn - thr - gly - ser - gly - thr - pro - NH 2 ; H- his - lys(BOC) - tyr - gln - thr - tyr - pro - argthr - asn - thr - gly - ser - gly - thr - pro - NH 2 ; (H or Z) - glu(OtBn) - leu - OMe; (Z or H) - glnglu(OtBu) - leu - OMe; Z - lys(BOC) - leu - ser- OMe; trityl - gly - lys(BOC) - leu - ser - NHNH 2 ; trityl - gly - lys(BOC) - leu - ser - gln - glu(OtBn)- leu - (NHNH 2 or OMe); H - gly - lys(BOC) - leuser - gln - glu(OtBn) - leu - his - lys(BOC) - leugln - thr - tyr - pro - arg - thr - asn - thr - gly- ser - gly - thr - pro - NH 2 ; (H or Z) - gln - leu- OMe; (H or Z) - glu - gln - leu - OMe; tritylgly - lys(BOC) - leu - ser - gin - gln - leu- NHNH 2 ; H - gly - lys(BOC) - leu - ser - glngln - leu - his - lys(BOC) - leu - gln - thr - tyrpro - arg - thr - asn - thr - gly - ser - gly - thrpro - NH 2 ; H - gly - lys(BOC) - leu - ser - glnglu(OtBu) - leu - his - lys(BOC) - tyr - glu - thrtyr - pro - arg - thr - asn - thr - gly - ser - gly - thrpro - NH 2 ; H - gly - lys(BOC) - leu - ser - glngln - leu - his - lys(BOC) - tyr - gin - thr - tyrpro - arg - thr - asn - thr - gly - ser - gly - thrpro - NH 2 ; (H or Z) - cys(Bz) - val - leu - OMe; (H or Z) - thr - cys(Bz) - val - leu - OMe; H - thrcys(Bz) - val - leu - OH; (BOC or H) - asn - leuser - OMe; (BOC or H) - ser - asn - leu - ser- OMe; BOC - cys(Bz) - ser - asn - leu - ser- (NHNH 2 or OMe); BOC - cys - ser - asn - leuser - thr - cys - val - leu - OH; BOC - cys(Bz)- ser - asnleu - ser - thr - cys(Bz) - val - leu - OH; BOC - cys - ser - asn - leu-ser-thr-cys-val-leu- OH; pivaloyl - cys - ser - asn - leu - ser - thr - cysval-leu-OH; pivalic acid p-nitrophenyl ester; ethoxycarbonyl - cys - ser - arn - leu - ser - thr - cys - val-leu-OH; carbonic acid p-nitrophenyl ethyl ester; benzylmercaptopropionyl-ser-asn-leu-ser- # NHNH 2 ; and S-CH 2 CH 2 CO-ser - asn - leuser-thr-cys-val-leu-NHNH 2 . Pharmaceutical compositions comprise a compound I together with a suitable carrier and/or diluent and lower the calcium content in the blood.
[GB1314051A]
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE1172/73A IE35078B1 (en) | 1969-06-03 | 1970-06-02 | Peptides |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH840569 | 1969-06-03 | ||
| CH945369 | 1969-06-20 | ||
| CH946169 | 1969-06-20 | ||
| CH945169 | 1969-06-20 | ||
| CH945269 | 1969-06-20 | ||
| CH956069 | 1969-06-23 | ||
| CH956169 | 1969-06-23 | ||
| CH955969 | 1969-06-23 | ||
| CH979269 | 1969-06-26 | ||
| CH995769A CH515216A (en) | 1969-06-30 | 1969-06-30 | Synthetic polypeptides - salmon calcitonin derivs. with pharmacodynamic properties |
| CH1361269 | 1969-09-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35077L true IE35077L (en) | 1970-12-03 |
| IE35077B1 IE35077B1 (en) | 1975-11-12 |
Family
ID=27581430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE709/70A IE35077B1 (en) | 1969-06-03 | 1970-06-02 | Polypeptides and their derivatives |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5429513B1 (en) |
| CA (1) | CA967950A (en) |
| DK (1) | DK144563C (en) |
| FI (1) | FI54800C (en) |
| GB (1) | GB1314051A (en) |
| HK (1) | HK52476A (en) |
| IE (1) | IE35077B1 (en) |
| IL (1) | IL34630A (en) |
| NO (1) | NO137087C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4499079A (en) * | 1982-11-18 | 1985-02-12 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
| US4663309A (en) * | 1983-06-29 | 1987-05-05 | University Patents, Inc. | Novel peptide hormones with calcitonin-like activity |
-
1970
- 1970-05-22 GB GB2477970A patent/GB1314051A/en not_active Expired
- 1970-06-01 IL IL34630A patent/IL34630A/en unknown
- 1970-06-01 CA CA084,227A patent/CA967950A/en not_active Expired
- 1970-06-01 NO NO2120/70A patent/NO137087C/en unknown
- 1970-06-02 IE IE709/70A patent/IE35077B1/en unknown
- 1970-06-02 JP JP4711670A patent/JPS5429513B1/ja active Pending
- 1970-06-02 FI FI1558/70A patent/FI54800C/en active
- 1970-06-02 DK DK285470A patent/DK144563C/en not_active IP Right Cessation
-
1976
- 1976-08-19 HK HK524/76*UA patent/HK52476A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA967950A (en) | 1975-05-20 |
| DK144563C (en) | 1982-09-20 |
| FI54800B (en) | 1978-11-30 |
| HK52476A (en) | 1976-08-27 |
| IL34630A0 (en) | 1970-08-19 |
| FI54800C (en) | 1979-03-12 |
| IE35077B1 (en) | 1975-11-12 |
| IL34630A (en) | 1973-10-25 |
| JPS5429513B1 (en) | 1979-09-25 |
| NO137087C (en) | 1977-12-28 |
| NO137087B (en) | 1977-09-19 |
| DK144563B (en) | 1982-03-29 |
| GB1314051A (en) | 1973-04-18 |
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