IE35154L - Migrane relief - Google Patents
Migrane reliefInfo
- Publication number
- IE35154L IE35154L IE701554A IE155470A IE35154L IE 35154 L IE35154 L IE 35154L IE 701554 A IE701554 A IE 701554A IE 155470 A IE155470 A IE 155470A IE 35154 L IE35154 L IE 35154L
- Authority
- IE
- Ireland
- Prior art keywords
- migraine
- compositions
- paracetamol
- dec
- treatment
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 3
- 208000019695 Migraine disease Diseases 0.000 abstract 3
- 206010027599 migraine Diseases 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 2
- 229960005489 paracetamol Drugs 0.000 abstract 2
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 1, 4-disubstituted piperazine Chemical class 0.000 abstract 1
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 abstract 1
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical class [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- MOYGZHXDRJNJEP-UHFFFAOYSA-N buclizine Chemical compound C1=CC(C(C)(C)C)=CC=C1CN1CCN(C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)CC1 MOYGZHXDRJNJEP-UHFFFAOYSA-N 0.000 abstract 1
- 229960001705 buclizine Drugs 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229960004126 codeine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 abstract 1
- 229960004193 dextropropoxyphene Drugs 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 235000011087 fumaric acid Nutrition 0.000 abstract 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960003893 phenacetin Drugs 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229960000581 salicylamide Drugs 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1311286 Migraine treatment H WILD 4 Dec 1970 [5 Dec 1969] 59643/69 Heading A5B Pharmaceutical compositions for the treatment and prevention of migraine comprise (a) a 1, 4-disubstituted piperazine having the general formula: wherein X is H, Cl or Br and R<SP>1</SP> and R<SP>2</SP> each represent H or a C 1-6 alkyl, at least one of R<SP>1</SP> and R<SP>2</SP> being an alkyl group, or a salt thereof e.g. salts with hydrochloric, phosphoric, lactic, maleic, fumaric and tartaric acids, and (b) N-acetyl-p-aminophenol (paracetamol), pethoxyacetanilide (phenacetin), salicylamide and/or acetylsalicylic acid, the weight ratio of (a) to (b) being from 1:20 to 1:200. A preferred composition comprises 1-p-chlorobenzhydryl-4- p-(tertiary butyl) benzyl piperazine (buclizine) and paracetamol. The compositions may be administered orally or rectally in the form of tablets, capsules, suspensions, syrups, and suppositories. Migraine may be prevented by the simultaneous administration of dosage units comprising appropriate quantities of (a) and (b) and the invention also relates to a pharmaceutical package comprising separate dosage unit forms containing (a) and (b). The composition may also be formulated as a dosage form divided into separate portions by an internal division which is easily ruptured or dissolved by body fluid, compounds (a) and (b) being confined to different compartments. The compositions may also contain additional analgesics such as codeine or dextropropoxyphene.
[GB1311286A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5964369A GB1311286A (en) | 1969-12-05 | 1969-12-05 | Compositions for the relief of migraine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35154L true IE35154L (en) | 1971-06-05 |
| IE35154B1 IE35154B1 (en) | 1975-11-26 |
Family
ID=10484150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1554/70A IE35154B1 (en) | 1969-12-05 | 1970-12-04 | Compositions for the relief of migraine |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT312161B (en) |
| BE (1) | BE759897A (en) |
| CA (1) | CA967882A (en) |
| CY (1) | CY717A (en) |
| FR (1) | FR2081330B1 (en) |
| GB (1) | GB1311286A (en) |
| IE (1) | IE35154B1 (en) |
| NL (1) | NL7017680A (en) |
| SE (1) | SE384135B (en) |
| ZA (1) | ZA708099B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU541247B2 (en) * | 1979-12-20 | 1985-01-03 | R.P. Scherer Corporation | Adjuvants for rectal delivery of drug substances |
| GB8521350D0 (en) * | 1985-08-28 | 1985-10-02 | Euro Celtique Sa | Analgesic composition |
-
1969
- 1969-12-05 GB GB5964369A patent/GB1311286A/en not_active Expired
-
1970
- 1970-11-30 ZA ZA708099*A patent/ZA708099B/en unknown
- 1970-12-03 SE SE7016368A patent/SE384135B/en unknown
- 1970-12-03 NL NL7017680A patent/NL7017680A/xx unknown
- 1970-12-04 BE BE759897D patent/BE759897A/en not_active IP Right Cessation
- 1970-12-04 FR FR7043778A patent/FR2081330B1/fr not_active Expired
- 1970-12-04 IE IE1554/70A patent/IE35154B1/en unknown
- 1970-12-07 AT AT1096570A patent/AT312161B/en not_active IP Right Cessation
- 1970-12-07 CA CA099,931A patent/CA967882A/en not_active Expired
-
1974
- 1974-01-28 CY CY71774A patent/CY717A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT312161B (en) | 1973-12-27 |
| DE2059747A1 (en) | 1971-06-09 |
| NL7017680A (en) | 1971-06-08 |
| DE2059747B2 (en) | 1976-04-22 |
| ZA708099B (en) | 1971-08-25 |
| FR2081330B1 (en) | 1974-10-11 |
| CY717A (en) | 1974-01-28 |
| IE35154B1 (en) | 1975-11-26 |
| BE759897A (en) | 1971-05-17 |
| GB1311286A (en) | 1973-03-28 |
| FR2081330A1 (en) | 1971-12-03 |
| CA967882A (en) | 1975-05-20 |
| SE384135B (en) | 1976-04-26 |
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