IE35505L - Heterocyclic thiourea derivatives. - Google Patents
Heterocyclic thiourea derivatives.Info
- Publication number
- IE35505L IE35505L IE710714A IE71471A IE35505L IE 35505 L IE35505 L IE 35505L IE 710714 A IE710714 A IE 710714A IE 71471 A IE71471 A IE 71471A IE 35505 L IE35505 L IE 35505L
- Authority
- IE
- Ireland
- Prior art keywords
- imidazolyl
- formula
- lower alkyl
- alkyl
- thiourea derivatives
- Prior art date
Links
- -1 Heterocyclic thiourea derivatives Chemical class 0.000 title abstract 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- SBPIDKODQVLBGV-UHFFFAOYSA-N 1h-imidazole;pyridine Chemical compound C1=CNC=N1.C1=CC=NC=C1 SBPIDKODQVLBGV-UHFFFAOYSA-N 0.000 abstract 1
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229940125715 antihistaminic agent Drugs 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Tires In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
N-(heterocyclyl)-alkyl-thioureas-selective antihistamines. The compns contain thio-ureas of formula (I): in which A is a divalent radical completing an unsatd. 5- or 6-membered heterocyclic ring, e.g. imidazole pyridine, thiazole or 1,2,4-triazole, X is H, lower alkyl, halogen or lower alkylthio, n is 3-6, and R is H lower alkyl, opt. substd. aryl or aralkyl (excluding benzyl), in combination with a pharmaceutical diluent or carrier. Cpds. of formula (I) in which R = CH3, n = 4, and A completes a 4(5)-imidazolyl, 4-bromo-5-imidazolyl or 2-thiazolyl ring are new. (I) inhibit certain effects of histamine, e.g. stimulation of gastric secretion.
[FR2100822A1]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3083470 | 1970-06-25 | ||
| GB4900770 | 1970-10-15 | ||
| GB291871 | 1971-01-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35505L true IE35505L (en) | 1971-12-25 |
| IE35505B1 IE35505B1 (en) | 1976-03-03 |
Family
ID=27254147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE714/71A IE35505B1 (en) | 1970-06-25 | 1971-06-03 | Thiourea derivatives |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5738583B1 (en) |
| BE (1) | BE768474A (en) |
| CA (1) | CA938556A (en) |
| CH (1) | CH551409A (en) |
| DE (1) | DE2131625A1 (en) |
| ES (1) | ES392628A2 (en) |
| FR (1) | FR2100822A1 (en) |
| HK (1) | HK55076A (en) |
| IE (1) | IE35505B1 (en) |
| IL (1) | IL36980A (en) |
| KE (1) | KE2624A (en) |
| NL (1) | NL7108585A (en) |
| PH (1) | PH11791A (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1565647A (en) * | 1975-07-31 | 1980-04-23 | Smith Kline French Lab | Pharmacologically active compounds 4-substituted-imidazole-5-methanols |
| DE3107599C2 (en) * | 1981-02-27 | 1982-12-16 | Ludwig Heumann & Co GmbH, 8500 Nürnberg | N-cyano-N'-methyl-N "- {2 - [(5-methylthio-imidazol-4-yl) -methylthio] -ethyl} -guanidine, process for its preparation and medicaments containing this compound |
| USRE37303E1 (en) * | 1992-01-10 | 2001-07-31 | Institut National Del La Sante Et De La Recherche Medicale | Imidazole compounds and their therapeutic applications |
| FR2686084B1 (en) * | 1992-01-10 | 1995-12-22 | Bioprojet Soc Civ | NEW IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS. |
| AU7823894A (en) * | 1993-08-27 | 1995-03-21 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| NL9302045A (en) * | 1993-08-27 | 1995-03-16 | Vrije Universiteit | New imidazole derivative with agonistic or antagonistic activity on the histamine H3 receptor |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE758145A (en) * | 1969-10-29 | 1971-04-28 | Smith Kline French Lab | ISO-THIO-UREES AND DERIVATIVES |
-
1971
- 1971-06-01 CA CA114497A patent/CA938556A/en not_active Expired
- 1971-06-03 IE IE714/71A patent/IE35505B1/en unknown
- 1971-06-03 IL IL36980A patent/IL36980A/en unknown
- 1971-06-04 PH PH12587A patent/PH11791A/en unknown
- 1971-06-14 BE BE768474A patent/BE768474A/en not_active IP Right Cessation
- 1971-06-21 FR FR7122512A patent/FR2100822A1/en active Granted
- 1971-06-22 NL NL7108585A patent/NL7108585A/xx not_active Application Discontinuation
- 1971-06-24 CH CH928871A patent/CH551409A/en not_active IP Right Cessation
- 1971-06-25 DE DE19712131625 patent/DE2131625A1/en not_active Withdrawn
- 1971-06-25 JP JP4675871A patent/JPS5738583B1/ja active Pending
- 1971-06-25 ES ES392628A patent/ES392628A2/en not_active Expired
-
1976
- 1976-05-18 KE KE2624*UA patent/KE2624A/en unknown
- 1976-09-08 HK HK550/76*UA patent/HK55076A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH551409A (en) | 1974-07-15 |
| HK55076A (en) | 1976-09-17 |
| FR2100822B1 (en) | 1974-11-15 |
| PH11791A (en) | 1978-07-05 |
| BE768474A (en) | 1971-12-14 |
| IL36980A (en) | 1978-07-31 |
| CA938556A (en) | 1973-12-18 |
| KE2624A (en) | 1976-05-28 |
| NL7108585A (en) | 1971-12-28 |
| JPS5738583B1 (en) | 1982-08-16 |
| DE2131625A1 (en) | 1971-12-30 |
| IE35505B1 (en) | 1976-03-03 |
| ES392628A2 (en) | 1975-07-16 |
| FR2100822A1 (en) | 1972-03-24 |
| IL36980A0 (en) | 1971-08-25 |
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