IE35767L - Isoindolines - Google Patents
IsoindolinesInfo
- Publication number
- IE35767L IE35767L IE711342A IE134271A IE35767L IE 35767 L IE35767 L IE 35767L IE 711342 A IE711342 A IE 711342A IE 134271 A IE134271 A IE 134271A IE 35767 L IE35767 L IE 35767L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- nnr2r3
- acid
- ester
- phthalic
- Prior art date
Links
- GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical class C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- QGXNHCXKWFNKCG-UHFFFAOYSA-N 2-(bromomethyl)benzonitrile Chemical compound BrCC1=CC=CC=C1C#N QGXNHCXKWFNKCG-UHFFFAOYSA-N 0.000 abstract 2
- WNZQDUSMALZDQF-UHFFFAOYSA-N 2-benzofuran-1(3H)-one Chemical compound C1=CC=C2C(=O)OCC2=C1 WNZQDUSMALZDQF-UHFFFAOYSA-N 0.000 abstract 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 abstract 2
- YCWRFIYBUQBHJI-UHFFFAOYSA-N 2-(4-aminophenyl)acetonitrile Chemical compound NC1=CC=C(CC#N)C=C1 YCWRFIYBUQBHJI-UHFFFAOYSA-N 0.000 abstract 1
- WQBXDMCOVLBREU-UHFFFAOYSA-N 3h-2-benzofuran-1-thione Chemical compound C1=CC=C2C(=S)OCC2=C1 WQBXDMCOVLBREU-UHFFFAOYSA-N 0.000 abstract 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- CFNDVXUTYPXOPG-UHFFFAOYSA-N ethyl 2-(4-aminophenyl)acetate Chemical compound CCOC(=O)CC1=CC=C(N)C=C1 CFNDVXUTYPXOPG-UHFFFAOYSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Title compds. of formula (I): where R is H or (1-4C) alkyl, and R1 is H, (1-4C) alkyl or -(CH2)nNR2R3 where n is 1 or 2 and R2 and R3 are H or (1-4C) alkyl, and salts of (I) (R1 = H or (CH2)nNR2R3), are anti-inflammatories and analgesics. Cpds. are rpepd. by condensing (a) o-cyanobenzylbromide (III) with a p-aminophenylacetonitrile or a p-aminophenylacetic acid ethyl ester (IV), (b) phthalide, thiophthalide or phthalaldehyde with (IV), (c) phthalic anhydride or a phthalic acid, Me or Et ester with (IV) followed by partial reduction of the intermediate, and in each case (a, b and c) hydrolysing with strong acid or base to (I) (R1 = H) and (opt.) esterifying.
[FR2112480A1]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT3133470 | 1970-11-05 | ||
| IT3151470 | 1970-11-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35767L true IE35767L (en) | 1972-05-05 |
| IE35767B1 IE35767B1 (en) | 1976-05-12 |
Family
ID=26328923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1342/71A IE35767B1 (en) | 1970-11-05 | 1971-10-25 | Isoindoline compounds |
Country Status (18)
| Country | Link |
|---|---|
| JP (6) | JPS5111627B1 (en) |
| AT (1) | AT313894B (en) |
| BE (1) | BE774985A (en) |
| CA (1) | CA978973A (en) |
| CH (4) | CH559175A5 (en) |
| DD (1) | DD95379A5 (en) |
| DK (1) | DK154761C (en) |
| ES (1) | ES396473A1 (en) |
| FI (1) | FI54294C (en) |
| FR (1) | FR2112480A1 (en) |
| HU (1) | HU164391B (en) |
| IE (1) | IE35767B1 (en) |
| IL (1) | IL38023A (en) |
| MY (1) | MY7400288A (en) |
| NL (1) | NL170283C (en) |
| NO (1) | NO135785C (en) |
| SE (1) | SE374917B (en) |
| YU (1) | YU34984B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154525A1 (en) * | 1970-11-05 | 1972-06-15 | Carlo Erba S.P.A., Mailand (Italien) | Isoindoline derivatives and processes for their preparation |
| DE2755345A1 (en) * | 1977-04-05 | 1978-10-19 | Grelan Pharmaceutical Co | 2-OXO-PHENYLBUTTERIC ACID DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS |
| JPS53145735U (en) * | 1977-04-23 | 1978-11-16 | ||
| JPS545333U (en) * | 1977-06-15 | 1979-01-13 | ||
| JPS5416115U (en) * | 1977-07-01 | 1979-02-01 | ||
| JPS5424235U (en) * | 1977-07-20 | 1979-02-17 | ||
| US5480362A (en) * | 1992-09-03 | 1996-01-02 | Honda Giken Kogyo Kabushiki Kaisha | Double planetary carrier |
| CN1302881C (en) * | 2004-12-10 | 2007-03-07 | 华东理工大学 | Method and apparatus for preparing superfine powder by super high pressure supercritical fluid micro jetting technology |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2034240C2 (en) * | 1968-03-27 | 1982-12-02 | CIBA-GEIGY AG, 4002 Basel | Isoindoline derivatives, processes for the preparation of these compounds and their use |
| JPS5035076A (en) * | 1973-08-01 | 1975-04-03 |
-
1971
- 1971-10-22 FI FI2988/71A patent/FI54294C/en active
- 1971-10-25 IE IE1342/71A patent/IE35767B1/en unknown
- 1971-10-27 IL IL38023A patent/IL38023A/en unknown
- 1971-10-28 ES ES396473A patent/ES396473A1/en not_active Expired
- 1971-10-29 YU YU2756/71A patent/YU34984B/en unknown
- 1971-11-04 SE SE7114082A patent/SE374917B/xx unknown
- 1971-11-04 CA CA126,830A patent/CA978973A/en not_active Expired
- 1971-11-04 DD DD158754A patent/DD95379A5/xx unknown
- 1971-11-04 AT AT952271A patent/AT313894B/en not_active IP Right Cessation
- 1971-11-04 HU HUCA317A patent/HU164391B/hu unknown
- 1971-11-04 NO NO4082/71A patent/NO135785C/no unknown
- 1971-11-05 DK DK541671A patent/DK154761C/en not_active IP Right Cessation
- 1971-11-05 FR FR7139823A patent/FR2112480A1/en active Granted
- 1971-11-05 CH CH1247674A patent/CH559175A5/xx not_active IP Right Cessation
- 1971-11-05 BE BE774985A patent/BE774985A/en not_active IP Right Cessation
- 1971-11-05 NL NLAANVRAGE7115288,A patent/NL170283C/en not_active IP Right Cessation
- 1971-11-05 CH CH1615771A patent/CH558353A/en not_active IP Right Cessation
- 1971-11-05 CH CH1247574A patent/CH559174A5/xx not_active IP Right Cessation
- 1971-11-05 CH CH1247774A patent/CH559176A5/xx not_active IP Right Cessation
- 1971-11-05 JP JP46088188A patent/JPS5111627B1/ja active Pending
-
1974
- 1974-12-30 MY MY288/74A patent/MY7400288A/en unknown
-
1975
- 1975-10-24 JP JP50128260A patent/JPS5168563A/en active Granted
-
1976
- 1976-04-02 JP JP51037028A patent/JPS5217463A/en active Pending
- 1976-04-02 JP JP51037027A patent/JPS5231066A/en active Granted
- 1976-04-02 JP JP51037026A patent/JPS5231065A/en active Granted
-
1978
- 1978-09-14 JP JP53113483A patent/JPS6019748B2/en not_active Expired
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