IE36203L - Pharmaceutical compositions - Google Patents
Pharmaceutical compositionsInfo
- Publication number
- IE36203L IE36203L IE720281A IE28172A IE36203L IE 36203 L IE36203 L IE 36203L IE 720281 A IE720281 A IE 720281A IE 28172 A IE28172 A IE 28172A IE 36203 L IE36203 L IE 36203L
- Authority
- IE
- Ireland
- Prior art keywords
- penicillin
- salts
- methyl
- benzyl
- penicilloyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 5-amino-5-carboxypentyl Chemical group 0.000 abstract 13
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 9
- 229930182555 Penicillin Natural products 0.000 abstract 5
- 229940049954 penicillin Drugs 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 3
- 239000011734 sodium Substances 0.000 abstract 3
- 229910052708 sodium Inorganic materials 0.000 abstract 3
- 206010013700 Drug hypersensitivity Diseases 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 235000019371 penicillin G benzathine Nutrition 0.000 abstract 2
- 229940056360 penicillin g Drugs 0.000 abstract 2
- KLIDCXVFHGNTTM-UHFFFAOYSA-N 2,6-dimethoxyphenol Chemical group COC1=CC=CC(OC)=C1O KLIDCXVFHGNTTM-UHFFFAOYSA-N 0.000 abstract 1
- 125000006024 2-pentenyl group Chemical group 0.000 abstract 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229960002684 aminocaproic acid Drugs 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- WGQKYBSKWIADBV-UHFFFAOYSA-O benzylaminium Chemical compound [NH3+]CC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-O 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Chemical class 0.000 abstract 1
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 abstract 1
- 239000011707 mineral Chemical class 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 201000005354 penicillin allergy Diseases 0.000 abstract 1
- 229960004894 pheneticillin Drugs 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 abstract 1
- 229960004919 procaine Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1322149 Penicillin compositions F HOFFMANN-LA ROCHE & CO AG 10 March 1972 [11 March 1971] 11351/72 Heading A5B [Also in Division C2] Pharmaceutical compositions for penicillin treatment where a penicillin allergy exists or is suspected and for the prophylactic treatment of penicillin allergies contain a therapeutically active penicillin and a penicilloyl acid derivative of the formula: wherein X represents a hydrogen atom or a group of the formula R'-NH- in which R' represents a hydrogen atom or a C 1-7 acyl group, n represents a whole number from 1-4 and R represents 2-pentenyl, n-pentyl, nheptyl, allylthiomethyl, 5-amino-5-carboxypentyl, benzyl, carboxybenzyl, α-aminobenzyl, phenoxybenzyl, phenoxymethyl, α-phenoxyethyl, α-phenoxypropyl, 2, 6-dimethoxyphenyl, 2-ethoxy-1-naphthyl, 3-carboxy-2-quinoxalinyl, 5-methyl-3-phenyl - 4 - isoxazolyl, 3 - (2-chlorophenyl)-5-methyl-4-isoxazolyl, 3-(2, 6-dichlorophenyl)-5-methyl-4-isoxazolyl or 2-furoyloxyisobutyl or a pharmaceutically acceptable salt thereof. Preferably the therapeutically active penicillin is benzyl penicillin, α-phenoxyethylpenicillin, sodium 2, 6-dimethoxyphenylpenicillin monohydrate, sodium 3-(2-chlorophenyl)-5- methyl-4-isoxozolylpenicillin monohydrate or α-aminobenzylpenicillin or salts or hydrates thereof. Salts referred to include organic ammonium salts such as the procaine, bis benzylammonium or bisdicyclohexylammonium salts and mineral salts such as the sodium, potassium or calcium salts. R in the penicilloyl acid derivative is preferably the same as in the therapeutically active penicillin and a preferred composition comprises benzyl penicillin and N<SP>6</SP>-(benzyl-α-penicilloyl)aminocaproic acid. The compositions may be administered enterally or parenterally in the form of tablets, dragÚes, suppositories, capsules, salves, solutions, suspensions or emulsions.
[GB1322149A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH355871 | 1971-03-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36203L true IE36203L (en) | 1972-09-11 |
| IE36203B1 IE36203B1 (en) | 1976-09-15 |
Family
ID=4258572
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE282/72A IE36204B1 (en) | 1971-03-11 | 1972-03-07 | Penicilloic acid derivatives |
| IE281/72A IE36203B1 (en) | 1971-03-11 | 1972-03-07 | Pharmaceutical compositions |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE282/72A IE36204B1 (en) | 1971-03-11 | 1972-03-07 | Penicilloic acid derivatives |
Country Status (21)
| Country | Link |
|---|---|
| AT (2) | AT312802B (en) |
| AU (1) | AU461136B2 (en) |
| BE (2) | BE780472A (en) |
| CA (1) | CA972759A (en) |
| CH (1) | CH546783A (en) |
| DE (2) | DE2211420A1 (en) |
| DK (1) | DK136977B (en) |
| ES (2) | ES400623A1 (en) |
| FI (1) | FI52345C (en) |
| FR (2) | FR2128824B1 (en) |
| GB (2) | GB1322149A (en) |
| HK (1) | HK14676A (en) |
| HU (2) | HU166712B (en) |
| IE (2) | IE36204B1 (en) |
| IL (2) | IL38864A (en) |
| NL (2) | NL7202771A (en) |
| NO (1) | NO138142C (en) |
| PH (2) | PH12264A (en) |
| SE (3) | SE406198B (en) |
| YU (1) | YU35011B (en) |
| ZA (2) | ZA721364B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316882A (en) * | 1978-04-20 | 1982-02-23 | Levine Bernard B | Compositions for testing to predict and/or diagnose allergy to penicillins |
| CA1209477A (en) * | 1981-03-26 | 1986-08-12 | Bruce E. Haeger | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
-
1971
- 1971-03-11 CH CH355871A patent/CH546783A/en not_active IP Right Cessation
-
1972
- 1972-03-01 ZA ZA721364A patent/ZA721364B/en unknown
- 1972-03-01 IL IL38864A patent/IL38864A/en unknown
- 1972-03-01 IL IL38865A patent/IL38865A/en unknown
- 1972-03-01 ZA ZA721363A patent/ZA721363B/en unknown
- 1972-03-02 NL NL7202771A patent/NL7202771A/xx not_active Application Discontinuation
- 1972-03-02 AU AU39571/72A patent/AU461136B2/en not_active Expired
- 1972-03-02 PH PH13316A patent/PH12264A/en unknown
- 1972-03-02 NL NL7202772A patent/NL7202772A/xx unknown
- 1972-03-03 PH PH13315*UA patent/PH9295A/en unknown
- 1972-03-06 CA CA136,277A patent/CA972759A/en not_active Expired
- 1972-03-07 AT AT188772A patent/AT312802B/en not_active IP Right Cessation
- 1972-03-07 IE IE282/72A patent/IE36204B1/en unknown
- 1972-03-07 AT AT188672A patent/AT331389B/en not_active IP Right Cessation
- 1972-03-07 IE IE281/72A patent/IE36203B1/en unknown
- 1972-03-08 FI FI720618A patent/FI52345C/en active
- 1972-03-09 DE DE19722211420 patent/DE2211420A1/en active Pending
- 1972-03-09 DE DE19722211419 patent/DE2211419A1/en active Pending
- 1972-03-10 GB GB1135172A patent/GB1322149A/en not_active Expired
- 1972-03-10 HU HUHO1459A patent/HU166712B/hu unknown
- 1972-03-10 GB GB1135272A patent/GB1333524A/en not_active Expired
- 1972-03-10 ES ES400623A patent/ES400623A1/en not_active Expired
- 1972-03-10 BE BE780472A patent/BE780472A/en unknown
- 1972-03-10 SE SE7203125A patent/SE406198B/en unknown
- 1972-03-10 YU YU625/72A patent/YU35011B/en unknown
- 1972-03-10 FR FR7208435A patent/FR2128824B1/fr not_active Expired
- 1972-03-10 DK DK112072AA patent/DK136977B/en unknown
- 1972-03-10 NO NO790/72A patent/NO138142C/en unknown
- 1972-03-10 HU HUHO1460A patent/HU165203B/hu unknown
- 1972-03-10 BE BE780471A patent/BE780471A/en unknown
- 1972-03-10 FR FR7208434A patent/FR2128823B1/fr not_active Expired
- 1972-03-10 ES ES400624A patent/ES400624A1/en not_active Expired
-
1975
- 1975-12-08 SE SE7513807A patent/SE7513807L/en unknown
- 1975-12-11 SE SE7514031A patent/SE7514031L/en unknown
-
1976
- 1976-03-18 HK HK146/76*UA patent/HK14676A/en unknown
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