IE36337L - Pharmaceutical compositions - Google Patents
Pharmaceutical compositionsInfo
- Publication number
- IE36337L IE36337L IE720564A IE56472A IE36337L IE 36337 L IE36337 L IE 36337L IE 720564 A IE720564 A IE 720564A IE 56472 A IE56472 A IE 56472A IE 36337 L IE36337 L IE 36337L
- Authority
- IE
- Ireland
- Prior art keywords
- sodium
- pharmaceutically acceptable
- chloride
- salt
- compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 abstract 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 235000019270 ammonium chloride Nutrition 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 239000002738 chelating agent Substances 0.000 abstract 2
- 239000003755 preservative agent Substances 0.000 abstract 2
- 230000002335 preservative effect Effects 0.000 abstract 2
- 239000003352 sequestering agent Substances 0.000 abstract 2
- 229940078693 1-myristylpicolinium Drugs 0.000 abstract 1
- ZCTSINFCZHUVLI-UHFFFAOYSA-M 4-methyl-1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=C(C)C=C1 ZCTSINFCZHUVLI-UHFFFAOYSA-M 0.000 abstract 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 abstract 1
- CXRFDZFCGOPDTD-UHFFFAOYSA-M Cetrimide Chemical compound [Br-].CCCCCCCCCCCCCC[N+](C)(C)C CXRFDZFCGOPDTD-UHFFFAOYSA-M 0.000 abstract 1
- 241000790917 Dioxys <bee> Species 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 125000006177 alkyl benzyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- -1 amino carboxylate compound Chemical class 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 abstract 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Substances OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 abstract 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 1
- 229960001484 edetic acid Drugs 0.000 abstract 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 206010023332 keratitis Diseases 0.000 abstract 1
- 201000010666 keratoconjunctivitis Diseases 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 229940097496 nasal spray Drugs 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1399834 Pharmaceutical compositions FISONS Ltd 21 April 1972 [12 May 1971 9 Dec 1971] 14529/71 and 57169/71 Heading A5B Pharmaceutical compositions comprising a clear, sterile aqueous solution containing as active ingredient a therapeutically useful proportion of 1, 3-bis (2-carboxy-chromon-5-yloxy)-propan-2-ol, or a pharmaceutically acceptable salt thereof, or of 5, 5'-[ [5, 5'-(2-hydroxytrimethylene) dioxy] bis [4-oxo-4H-1-benzopyran-2-yl] ] tetrazole, or a pharmaceutically acceptable salt thereof, may be prepared (a) by dissolving the component(s) of the composition in water, filtering the solution and sterilising the filtrate or (b) by mixing two aqueous solutions of equal volumes one containing twice the desired final concentration of the active ingredient, chelating or sequestering agent, and other additives, and the other containing twice the desired final concentration of the preservative. The compositions may contain an effective proportion of a pharmaceutically acceptable chelating or sequestering agent such as sodium carboxymethyl cellulose, citric, tartaric or phosphoric acid or an amino carboxylate compound e.g. ethylene diamine tetraacetic acid or a salt thereof such as the di-sodium salt; an effective proportion of a pharmaceutically acceptable preservative such as sodium 2-(ethyl mercuriothio) benzoate, a quaternary ammonium compound e.g. cetyl pyridinium chloride, tetradecyltrimethyl ammonium bromide, benzyl dimethyl [2-[2-[p-(1, 1, 3, 3-tetramethyl butyl)] phenoxy] ethoxy] ammonium chloride or myristyl-γ-picolinium chloride, an alkyl benzyl dimethyl ammonium chloride, a mixture of compounds of formula: in which R is an alkyl group C 8 H 17 to C 18 H 37 ; 2-phenyl ethanol; sodium chloride; and/or a buffer e.g. sodium dihydrogen orthophosphate and di-sodium hydrogen phosphate. The compositions are used as eye drops in the treatment of vermal kerato conjunctivitis, the ocular symptoms of hay fever and/or marginal corneal infiltration and as, a nasal spray in the treatment of hay fever. Reference has been directed by the comptroller to Specification 1144905.
[GB1399834A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1452971 | 1971-05-12 | ||
| GB5716971A GB1399834A (en) | 1971-05-12 | 1971-12-09 | Pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36337L true IE36337L (en) | 1972-11-12 |
| IE36337B1 IE36337B1 (en) | 1976-10-13 |
Family
ID=26250625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE564/72A IE36337B1 (en) | 1971-05-12 | 1972-04-28 | Pharmaceutical compositions |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5425082B1 (en) |
| AU (1) | AU465305B2 (en) |
| BE (1) | BE782981A (en) |
| CA (1) | CA1000201A (en) |
| CY (1) | CY955A (en) |
| DE (2) | DE2266025A1 (en) |
| DK (1) | DK131324B (en) |
| FR (1) | FR2139872B1 (en) |
| GB (1) | GB1399834A (en) |
| HK (1) | HK69276A (en) |
| IE (1) | IE36337B1 (en) |
| IL (1) | IL39286A (en) |
| MY (1) | MY7700080A (en) |
| NL (1) | NL177386B (en) |
| SE (1) | SE396011B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2230358A2 (en) * | 1973-05-25 | 1974-12-20 | Fisons Ltd | Cromoglycate contg. solns. - contg. a second therapeutically active cpd. e.g. an antihistamine |
| DE2634908A1 (en) * | 1974-11-09 | 1977-04-14 | Fisons Ltd | Bis carboxy-chromonyl-oxy alkane compsn. |
| DE3700379A1 (en) * | 1987-01-08 | 1988-07-21 | Mann Gerhard Chem Pharm Fab | PRESERVED EYE DROPS WITH A CROMOGLICIC ACID CONTENT |
| AT410894B (en) * | 1988-03-22 | 2003-08-25 | Fisons Plc | Aerosol dispensers contg. soln. of inhalation medicament |
| GB8819490D0 (en) * | 1988-08-16 | 1988-09-21 | Fisons Plc | Pharmaceutical devices |
| EP0338670B1 (en) * | 1988-03-22 | 1994-05-11 | FISONS plc | Pharmaceutical Compositions |
| FR2649890A1 (en) * | 1988-03-22 | 1991-01-25 | Fisons Plc | Pharmaceutical compositions |
| WO1997024142A1 (en) * | 1995-12-27 | 1997-07-10 | Showa Yakuhin Kako Co., Ltd. | Aqueous composition containing cromoglycic acid |
| DE19614823A1 (en) | 1996-04-15 | 1997-10-16 | Mann Gerhard Chem Pharm Fab | Ophthalmic composition with prolonged retention time on the eye |
| EP0938896A1 (en) * | 1998-01-15 | 1999-09-01 | Novartis AG | Autoclavable pharmaceutical compositions containing a chelating agent |
| JP5785353B2 (en) * | 2004-02-27 | 2015-09-30 | 大正製薬株式会社 | Ophthalmic agent |
| JP5992293B2 (en) * | 2012-10-31 | 2016-09-14 | 大正製薬株式会社 | Ophthalmic agent |
| PL426472A1 (en) * | 2018-07-27 | 2020-02-10 | Kalbarczyk Grzegorz Arkona Laboratorium Farmakologii Stomatologicznej | Medical use of domiphen bromide and a composition for treating inflammation in the oral cavity |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1144905A (en) * | 1965-03-25 | 1969-03-12 | Fisons Pharmaceuticals Ltd | Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof |
| GB1190193A (en) * | 1966-07-05 | 1970-04-29 | Fisons Pharmaceuticals Ltd | Bis-(2-Carboxy-Chromonyl-Oxy) Derivatives, their preparation, and Pharmaceutical Compositions thereof |
-
1971
- 1971-12-09 GB GB5716971A patent/GB1399834A/en not_active Expired
-
1972
- 1972-04-21 CY CY955A patent/CY955A/en unknown
- 1972-04-24 IL IL39286A patent/IL39286A/en unknown
- 1972-04-28 IE IE564/72A patent/IE36337B1/en unknown
- 1972-05-01 CA CA140,981A patent/CA1000201A/en not_active Expired
- 1972-05-03 BE BE782981A patent/BE782981A/en not_active IP Right Cessation
- 1972-05-09 NL NLAANVRAGE7206251,A patent/NL177386B/en not_active Application Discontinuation
- 1972-05-09 AU AU42080/72A patent/AU465305B2/en not_active Expired
- 1972-05-09 SE SE7206151A patent/SE396011B/en unknown
- 1972-05-10 FR FR7216640A patent/FR2139872B1/fr not_active Expired
- 1972-05-10 DK DK232472AA patent/DK131324B/en not_active IP Right Cessation
- 1972-05-12 DE DE19722266025 patent/DE2266025A1/de active Pending
- 1972-05-12 JP JP4653772A patent/JPS5425082B1/ja active Pending
- 1972-05-12 DE DE2223237A patent/DE2223237C2/en not_active Expired
-
1976
- 1976-11-04 HK HK692/76*UA patent/HK69276A/en unknown
-
1977
- 1977-12-31 MY MY197780A patent/MY7700080A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU4208072A (en) | 1973-11-15 |
| DE2223237A1 (en) | 1972-12-14 |
| NL177386B (en) | 1985-04-16 |
| DE2266025A1 (en) | 1985-03-07 |
| BE782981A (en) | 1972-11-03 |
| CY955A (en) | 1978-12-22 |
| IL39286A (en) | 1975-02-10 |
| HK69276A (en) | 1976-11-12 |
| AU465305B2 (en) | 1975-09-25 |
| CA1000201A (en) | 1976-11-23 |
| SE396011B (en) | 1977-09-05 |
| DK131324C (en) | 1975-11-24 |
| DK131324B (en) | 1975-06-30 |
| MY7700080A (en) | 1977-12-31 |
| JPS5425082B1 (en) | 1979-08-25 |
| GB1399834A (en) | 1975-07-02 |
| FR2139872A1 (en) | 1973-01-12 |
| IE36337B1 (en) | 1976-10-13 |
| NL7206251A (en) | 1972-11-14 |
| DE2223237C2 (en) | 1985-01-17 |
| FR2139872B1 (en) | 1975-10-31 |
| IL39286A0 (en) | 1972-06-28 |
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