IE36563L - Triazolo benzodiazepines - Google Patents

Triazolo benzodiazepines

Info

Publication number
IE36563L
IE36563L IE720982A IE98272A IE36563L IE 36563 L IE36563 L IE 36563L IE 720982 A IE720982 A IE 720982A IE 98272 A IE98272 A IE 98272A IE 36563 L IE36563 L IE 36563L
Authority
IE
Ireland
Prior art keywords
triazolo
chloro
methyl
benzodiazepine
methylamino
Prior art date
Application number
IE720982A
Other versions
IE36563B1 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IE36563L publication Critical patent/IE36563L/en
Publication of IE36563B1 publication Critical patent/IE36563B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compounds of the class of 2-(aminomethyl)-6-phenyl-4H-s-triazolo[1,5-a][1,4]benzodiazepines, their 5-oxides and the pharmaceutically acceptable acid addition salts of said compounds and their 5-oxides have valuable pharmacological properties, in particular anticonvulsant effectiveness, and are active ingredients for therapeutic preparations. Specific embodiments are 2-[(dimethylamino)-methyl]-6-phenyl-8-chloro-4H-s-triazolo[1,5-a][1,4] benzodiazepine, 2-[(methylamino)-methyl]-6-phenyl-8-chloro-4H-s-triazolo[1,5-a][1,4]be nzodiazepine, 2-[(dimethylamino)-methyl]-6-(o-fluorophenyl)-8-chloro-4H-s-triazolo[1 ,5-a][1,4]benzodiazepine, 2-[(methylamino)-methyl]-6-(o-fluorophenyl)-8-chloro-4H-s-triazolo[1,5 -a][1,4]benzodiazepine and 2-[(methylamino)-methyl]-6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[1,5 -a][1,4]benzodiazepine. [US3878205A]
IE982/72A 1971-07-23 1972-07-12 New diazepine derivatives and processes for their production IE36563B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1088571A CH553801A (en) 1971-07-23 1971-07-23 PROCESS FOR THE PRODUCTION OF NEW DIAZEPIN DERIVATIVES.

Publications (2)

Publication Number Publication Date
IE36563L true IE36563L (en) 1973-01-23
IE36563B1 IE36563B1 (en) 1976-12-08

Family

ID=4367854

Family Applications (1)

Application Number Title Priority Date Filing Date
IE982/72A IE36563B1 (en) 1971-07-23 1972-07-12 New diazepine derivatives and processes for their production

Country Status (23)

Country Link
US (1) US3878205A (en)
JP (1) JPS561316B1 (en)
AR (2) AR194603A1 (en)
AT (2) AT319956B (en)
AU (1) AU472145B2 (en)
BE (1) BE786530A (en)
CA (1) CA967956A (en)
CH (1) CH553801A (en)
CS (2) CS178450B2 (en)
DD (1) DD99578A5 (en)
DE (1) DE2234652A1 (en)
FI (1) FI52729C (en)
FR (1) FR2147092B1 (en)
GB (1) GB1395416A (en)
HU (1) HU165319B (en)
IE (1) IE36563B1 (en)
IL (1) IL39883A (en)
NL (1) NL7209809A (en)
NO (1) NO134868C (en)
PL (1) PL85681B1 (en)
SE (1) SE380804B (en)
SU (2) SU472505A3 (en)
ZA (1) ZA724839B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209516A (en) * 1974-01-14 1980-06-24 Ciba-Geigy Corporation Triazole derivatives
JPS5747915B2 (en) * 1974-04-17 1982-10-13
US4209515A (en) * 1974-06-14 1980-06-24 Ciba-Geigy Corporation Triazole derivatives
US3996230A (en) * 1975-03-28 1976-12-07 The Upjohn Company 1-Piperazino-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepines
US4510141A (en) * 1982-09-13 1985-04-09 Ciba-Geigy Corporation Tricyclic polyazaheterocycles for treating depression or anxiety
TWI878507B (en) 2020-03-31 2025-04-01 瑞士商赫孚孟拉羅股份公司 New benzodiazepine derivatives as gaba a gamma1 pam
JP2024537773A (en) 2021-09-29 2024-10-16 エフ． ホフマン－ラ ロシュ アーゲー Novel benzodiazepine derivatives as GABA Aγ1 PAMs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758921A (en) * 1969-11-15 1971-04-16 Takeda Chemical Industries Ltd BENZODIAZEPINE DERIVATIVES

Also Published As

Publication number Publication date
ZA724839B (en) 1973-04-25
SU497776A3 (en) 1975-12-30
SE380804B (en) 1975-11-17
PL85681B1 (en) 1976-04-30
FR2147092A1 (en) 1973-03-09
CS178450B2 (en) 1977-09-15
HU165319B (en) 1974-08-28
DD99578A5 (en) 1973-08-12
DE2234652A1 (en) 1973-02-01
AU4483772A (en) 1974-01-24
FI52729B (en) 1977-08-01
JPS561316B1 (en) 1981-01-13
AR194603A1 (en) 1973-07-31
NO134868C (en) 1976-12-29
US3878205A (en) 1975-04-15
CH553801A (en) 1974-09-13
CA967956A (en) 1975-05-20
AT319956B (en) 1975-01-27
IE36563B1 (en) 1976-12-08
SU472505A3 (en) 1975-05-30
NO134868B (en) 1976-09-20
NL7209809A (en) 1973-01-25
FR2147092B1 (en) 1975-08-08
BE786530A (en) 1973-01-22
GB1395416A (en) 1975-05-29
IL39883A0 (en) 1972-09-28
AR197989A1 (en) 1974-05-24
FI52729C (en) 1977-11-10
IL39883A (en) 1976-06-30
AU472145B2 (en) 1976-05-20
AT318625B (en) 1974-11-11
CS178411B2 (en) 1977-09-15

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