IE36820L - Compositions comprising 2-p-chlorophenoxy-2-methylpropionic¹acid and tocopherol - Google Patents
Compositions comprising 2-p-chlorophenoxy-2-methylpropionic¹acid and tocopherolInfo
- Publication number
- IE36820L IE36820L IE721489A IE148972A IE36820L IE 36820 L IE36820 L IE 36820L IE 721489 A IE721489 A IE 721489A IE 148972 A IE148972 A IE 148972A IE 36820 L IE36820 L IE 36820L
- Authority
- IE
- Ireland
- Prior art keywords
- tocopherol
- compositions
- chlorophenoxy
- esters
- lowering
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 229960001295 tocopherol Drugs 0.000 title abstract 3
- 239000011732 tocopherol Substances 0.000 title abstract 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title abstract 2
- 229930003799 tocopherol Natural products 0.000 title abstract 2
- 235000010384 tocopherol Nutrition 0.000 title abstract 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 abstract 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229940111131 antiinflammatory and antirheumatic product propionic acid derivative Drugs 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- TXCGAZHTZHNUAI-UHFFFAOYSA-N clofibric acid Chemical compound OC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 TXCGAZHTZHNUAI-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000871 hypocholesterolemic effect Effects 0.000 abstract 1
- -1 nicotinoyloxy groups Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 150000005599 propionic acid derivatives Chemical class 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 235000019155 vitamin A Nutrition 0.000 abstract 1
- 239000011719 vitamin A Substances 0.000 abstract 1
- 229940045997 vitamin a Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1382587 Blood cholesterol-lowering medicines IMPERIAL CHEMICAL INDUSTRIES Ltd 30 Oct 1972 [16 Dec 1971] 58398/71 Heading A5B Pharmaceutical compositions having hypocholesterolemic and serum triglyceride-lowering action comprise 2-p-chlorophenoxy-2- methylpropionic acid or an ester, amide or salt thereof and from 10 to 25% by weight thereof of a tocopherol having vitamin A activity, e.g. α-, #-, γ- or #-tocopherol, esters thereof and mixtures. Suitable esters of the propionic acid derivatives include those with alcohols R'OH where R' is piperidyl or alkyl substituted by pyridyl or nicotinoyloxy groups. The compositions may be in conventional orally administrable forms comprising the axial excipients and carriers.
[GB1382587A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5839871A GB1382587A (en) | 1971-12-16 | 1971-12-16 | Pharmaceutical compositions comprising 2-rho-chlorophenoxy-2- methylpropionic acid or a derivative and a tocopherol possessing vitamin e activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36820L true IE36820L (en) | 1973-06-16 |
| IE36820B1 IE36820B1 (en) | 1977-03-02 |
Family
ID=10481514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1489/72A IE36820B1 (en) | 1971-12-16 | 1972-11-02 | Pharmaceutical compositions comprising 2-p-chlorophenoxy-2-methylpropionic acid or a derivative and a tocopherol possessing vitamin e activity |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS4867420A (en) |
| AU (1) | AU470387B2 (en) |
| BE (1) | BE792855A (en) |
| CA (1) | CA981579A (en) |
| DE (1) | DE2261504A1 (en) |
| FR (1) | FR2163736B1 (en) |
| GB (1) | GB1382587A (en) |
| IE (1) | IE36820B1 (en) |
| IL (1) | IL40785A (en) |
| NL (1) | NL7216837A (en) |
| ZA (1) | ZA727855B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2730231B1 (en) * | 1995-02-02 | 1997-04-04 | Fournier Sca Lab | COMBINATION OF FENOFIBRATE AND VITAMIN E, USE IN THERAPEUTICS |
-
0
- BE BE792855D patent/BE792855A/en unknown
-
1971
- 1971-12-16 GB GB5839871A patent/GB1382587A/en not_active Expired
-
1972
- 1972-11-02 IE IE1489/72A patent/IE36820B1/en unknown
- 1972-11-06 ZA ZA727855A patent/ZA727855B/en unknown
- 1972-11-09 IL IL40785A patent/IL40785A/en unknown
- 1972-11-10 AU AU48736/72A patent/AU470387B2/en not_active Expired
- 1972-11-16 CA CA156,665A patent/CA981579A/en not_active Expired
- 1972-12-12 NL NL7216837A patent/NL7216837A/xx not_active Application Discontinuation
- 1972-12-15 DE DE19722261504 patent/DE2261504A1/en active Pending
- 1972-12-15 FR FR7244922A patent/FR2163736B1/fr not_active Expired
- 1972-12-15 JP JP47126036A patent/JPS4867420A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4867420A (en) | 1973-09-14 |
| CA981579A (en) | 1976-01-13 |
| NL7216837A (en) | 1973-06-19 |
| AU470387B2 (en) | 1976-03-11 |
| GB1382587A (en) | 1975-02-05 |
| IE36820B1 (en) | 1977-03-02 |
| BE792855A (en) | 1973-06-15 |
| IL40785A (en) | 1976-02-29 |
| IL40785A0 (en) | 1973-02-28 |
| DE2261504A1 (en) | 1973-06-28 |
| AU4873672A (en) | 1974-05-16 |
| FR2163736B1 (en) | 1976-03-05 |
| ZA727855B (en) | 1973-08-29 |
| FR2163736A1 (en) | 1973-07-27 |
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