IE36867L - Potentiated antimicrobial compositions - Google Patents
Potentiated antimicrobial compositionsInfo
- Publication number
- IE36867L IE36867L IE721103A IE110372A IE36867L IE 36867 L IE36867 L IE 36867L IE 721103 A IE721103 A IE 721103A IE 110372 A IE110372 A IE 110372A IE 36867 L IE36867 L IE 36867L
- Authority
- IE
- Ireland
- Prior art keywords
- aug
- alkyl
- optionally substituted
- competitor
- specified
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000000845 anti-microbial effect Effects 0.000 title 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- BYIRZDTVVMWWFI-UHFFFAOYSA-N 2h-pteridin-1-ylmethanol Chemical compound C1=CN=C2N(CO)CN=CC2=N1 BYIRZDTVVMWWFI-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108010022394 Threonine synthase Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229960004050 aminobenzoic acid Drugs 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- LDBTVAXGKYIFHO-UHFFFAOYSA-N diaveridine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=CN=C(N)N=C1N LDBTVAXGKYIFHO-UHFFFAOYSA-N 0.000 abstract 1
- 229950000246 diaveridine Drugs 0.000 abstract 1
- 102000004419 dihydrofolate reductase Human genes 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical compound N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 abstract 1
- WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 abstract 1
- 229960000611 pyrimethamine Drugs 0.000 abstract 1
- YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical class NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 abstract 1
- 229960001082 trimethoprim Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Fodder In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
1405246 Potentiated antibacterial medicines WELLCOME FOUNDATION LTD 4 Aug 1972 [5 Aug 1971 1 Aug 1972] 36774/71 and 35817/72 Heading A5B Antibacterial compositions comprise a competitor of p-aminobenzoic acid or an inhibitor of dihydrofolate reductase, or both, together with a potentiator which is itself a pteridine antagonist (as defined in the specification) and which inhibits the enzyme hydroxymethyldihydropteridine pyrophosphokinase and has a sufficiently low toxicity to a mammalion or arian host. Specified potentiatas are compounds of the formula: wherein R is -alkyl, optionally substituted by a hydroxy group, a halogen atom or by a phenoxy group itself optionally substituted by one or more alkoxy, amino, alkyl or hydroxy groups or halogen atoms and R<SP>1</SP> and R<SP>2</SP> are the same or different and is each alkyl or they form: together a C 4-6 spirocycloalkyl ring system. Specified competitor/inhibitor compounds are various sulphonamides, pyrimethamine, trimethoprim, diaveridine and various derivatives of 2, 4-diamino pyrimidine. The compositions may be put up into conventional forms for oral, parenteral and rectal administration.
[GB1405246A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3677471 | 1971-08-05 | ||
| GB3581772A GB1405246A (en) | 1971-08-05 | 1972-08-01 | Potentiated antimicrobial compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36867L true IE36867L (en) | 1973-02-05 |
| IE36867B1 IE36867B1 (en) | 1977-03-16 |
Family
ID=26262869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1103/72A IE36867B1 (en) | 1971-08-05 | 1972-08-04 | Potentiated antimicrobial compositions |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS6036409B2 (en) |
| BE (1) | BE787236A (en) |
| CS (1) | CS172956B2 (en) |
| DE (1) | DE2238536C2 (en) |
| FR (1) | FR2150733B1 (en) |
| GB (1) | GB1405246A (en) |
| HU (1) | HU170534B (en) |
| IE (1) | IE36867B1 (en) |
| IL (1) | IL40050A (en) |
| IT (1) | IT1057861B (en) |
| LU (1) | LU65857A1 (en) |
| NL (1) | NL7210719A (en) |
| NO (1) | NO139004C (en) |
| SE (1) | SE434337B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1454165A (en) * | 1972-08-01 | 1976-10-27 | Wellcome Found | Biologically active compounds and compositions |
| GB1451043A (en) * | 1972-08-01 | 1976-09-29 | Wellcome Found | Biologicylly acitve compounds and compositions |
| GB1469521A (en) * | 1973-01-05 | 1977-04-06 | Wellcome Found | Antimicrobial preparations |
| GB1596044A (en) * | 1977-04-14 | 1981-08-19 | Wellcome Found | Veterinary compositions |
| AU572792B2 (en) * | 1982-09-20 | 1988-05-19 | Wellcome Foundation Limited, The | 2-amino, 4-oxo-pteridine derivatives |
| JPS63121616U (en) * | 1987-01-30 | 1988-08-08 | ||
| CN113897413A (en) * | 2021-10-12 | 2022-01-07 | 广州达安基因股份有限公司 | In-vitro diagnostic reagent preservative and application thereof |
-
0
- BE BE787236D patent/BE787236A/en not_active IP Right Cessation
-
1972
- 1972-08-01 GB GB3581772A patent/GB1405246A/en not_active Expired
- 1972-08-04 CS CS5448A patent/CS172956B2/cs unknown
- 1972-08-04 HU HUWE464A patent/HU170534B/hu unknown
- 1972-08-04 NO NO2781/72A patent/NO139004C/en unknown
- 1972-08-04 DE DE2238536A patent/DE2238536C2/en not_active Expired
- 1972-08-04 IL IL40050A patent/IL40050A/en unknown
- 1972-08-04 LU LU65857A patent/LU65857A1/xx unknown
- 1972-08-04 IE IE1103/72A patent/IE36867B1/en unknown
- 1972-08-04 IT IT52002/72A patent/IT1057861B/en active
- 1972-08-04 NL NL7210719A patent/NL7210719A/xx unknown
- 1972-08-04 JP JP47078240A patent/JPS6036409B2/en not_active Expired
- 1972-08-04 SE SE7210162A patent/SE434337B/en unknown
- 1972-08-04 FR FR7228236A patent/FR2150733B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL40050A (en) | 1976-02-29 |
| IE36867B1 (en) | 1977-03-16 |
| DE2238536A1 (en) | 1973-02-22 |
| FR2150733A1 (en) | 1973-04-13 |
| CS172956B2 (en) | 1977-01-28 |
| SE434337B (en) | 1984-07-23 |
| LU65857A1 (en) | 1973-02-01 |
| IT1057861B (en) | 1982-03-30 |
| FR2150733B1 (en) | 1975-06-20 |
| BE787236A (en) | 1973-02-05 |
| GB1405246A (en) | 1975-09-10 |
| IL40050A0 (en) | 1972-10-29 |
| JPS6036409B2 (en) | 1985-08-20 |
| NL7210719A (en) | 1973-02-07 |
| NO139004B (en) | 1978-09-11 |
| JPS4828610A (en) | 1973-04-16 |
| DE2238536C2 (en) | 1984-11-29 |
| HU170534B (en) | 1977-06-28 |
| NO139004C (en) | 1978-12-20 |
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