IE37137L - Noracymethadol carbamates - Google Patents
Noracymethadol carbamatesInfo
- Publication number
- IE37137L IE37137L IE730104A IE10473A IE37137L IE 37137 L IE37137 L IE 37137L IE 730104 A IE730104 A IE 730104A IE 10473 A IE10473 A IE 10473A IE 37137 L IE37137 L IE 37137L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- noracymethadol
- carbamates
- jan
- butyl
- Prior art date
Links
- -1 Noracymethadol carbamates Chemical class 0.000 title abstract 2
- 229950008848 noracymethadol Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000004606 Fillers/Extenders Substances 0.000 abstract 1
- VWCUGCYZZGRKEE-UWJYYQICSA-N L-alpha-Acetyl-N-normethadol Chemical compound C=1C=CC=CC=1C(C[C@H](C)NC)([C@@H](OC(C)=O)CC)C1=CC=CC=C1 VWCUGCYZZGRKEE-UWJYYQICSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- WLIRKXIAZSUUBI-UHFFFAOYSA-N butan-2-yl N-chlorocarbamate Chemical compound ClNC(OC(C)CC)=O WLIRKXIAZSUUBI-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- FAMRKDQNMBBFBR-BQYQJAHWSA-N diethyl azodicarboxylate Substances CCOC(=O)\N=N\C(=O)OCC FAMRKDQNMBBFBR-BQYQJAHWSA-N 0.000 abstract 1
- QIRAYNIFEOXSPW-UHFFFAOYSA-N dimepheptanol Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(O)CC)C1=CC=CC=C1 QIRAYNIFEOXSPW-UHFFFAOYSA-N 0.000 abstract 1
- 229950004655 dimepheptanol Drugs 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- FAMRKDQNMBBFBR-UHFFFAOYSA-N ethyl n-ethoxycarbonyliminocarbamate Chemical compound CCOC(=O)N=NC(=O)OCC FAMRKDQNMBBFBR-UHFFFAOYSA-N 0.000 abstract 1
- 238000007912 intraperitoneal administration Methods 0.000 abstract 1
- XBMIVRRWGCYBTQ-AVRDEDQJSA-N levacetylmethadol Chemical compound C=1C=CC=CC=1C(C[C@H](C)N(C)C)([C@@H](OC(C)=O)CC)C1=CC=CC=C1 XBMIVRRWGCYBTQ-AVRDEDQJSA-N 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
- 238000005636 thioacylation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1374943 Noracymethadol carbamates ELI LILLY & CO 22 Jan 1973 [25 Jan 1972] 3091/73 Heading C2C The novel compounds of Formula I wherein Y is O or S, R is C 1 -C 5 alkyl or phenyl and R<SP>1</SP> is CH 3 or C 2 H 5 , may be prepared by acylation or thioacylation of the corresponding noracetyl or norpropionyl methadol or Formula II wherein R<SP>1</SP> is as defined above, preferably using ethyl, n-butyl or sec-butyl chlorocarbamate. α-l-Noracetylmethadol is prepared by reaction of α-l-acetylmethadol with diethylazodicarboxylate. Pharmaceutical compositions having analgesic activity for oral, intraperitoneal or subcutaneous administration comprise a compound of Formula I together with conventional extenders excipients or binders.
[GB1374943A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22069872A | 1972-01-25 | 1972-01-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37137L true IE37137L (en) | 1973-07-25 |
| IE37137B1 IE37137B1 (en) | 1977-05-11 |
Family
ID=22824588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE104/73A IE37137B1 (en) | 1972-01-25 | 1973-01-23 | Noracymethadol carbamates |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US3755416A (en) |
| JP (1) | JPS4881840A (en) |
| AR (1) | AR196511A1 (en) |
| AT (1) | AT320663B (en) |
| AU (1) | AU472051B2 (en) |
| BE (1) | BE794390A (en) |
| CH (1) | CH554847A (en) |
| CS (1) | CS164223B2 (en) |
| DD (1) | DD103892A5 (en) |
| DE (1) | DE2303021A1 (en) |
| ES (1) | ES410947A1 (en) |
| FR (1) | FR2181688B1 (en) |
| GB (1) | GB1374943A (en) |
| HU (1) | HU166566B (en) |
| IE (1) | IE37137B1 (en) |
| IL (1) | IL41308A (en) |
| NL (1) | NL7301122A (en) |
| PH (1) | PH9470A (en) |
| RO (1) | RO62268A (en) |
| SE (1) | SE376414B (en) |
| SU (1) | SU474138A3 (en) |
| ZA (1) | ZA73327B (en) |
-
0
- BE BE794390D patent/BE794390A/en unknown
-
1972
- 1972-01-25 ES ES410947A patent/ES410947A1/en not_active Expired
- 1972-01-25 US US00220698A patent/US3755416A/en not_active Expired - Lifetime
-
1973
- 1973-01-16 ZA ZA730327A patent/ZA73327B/en unknown
- 1973-01-17 IL IL41308A patent/IL41308A/en unknown
- 1973-01-18 AU AU51225/73A patent/AU472051B2/en not_active Expired
- 1973-01-19 PH PH14262*UA patent/PH9470A/en unknown
- 1973-01-22 GB GB309173A patent/GB1374943A/en not_active Expired
- 1973-01-22 DE DE2303021A patent/DE2303021A1/en active Pending
- 1973-01-22 SE SE7300839A patent/SE376414B/xx unknown
- 1973-01-23 IE IE104/73A patent/IE37137B1/en unknown
- 1973-01-24 FR FR7302473A patent/FR2181688B1/fr not_active Expired
- 1973-01-24 CH CH98773A patent/CH554847A/en not_active IP Right Cessation
- 1973-01-24 SU SU1878951A patent/SU474138A3/en active
- 1973-01-24 DD DD168422A patent/DD103892A5/xx unknown
- 1973-01-24 AT AT57873A patent/AT320663B/en not_active IP Right Cessation
- 1973-01-24 HU HUEI458A patent/HU166566B/hu unknown
- 1973-01-25 RO RO7300073606A patent/RO62268A/en unknown
- 1973-01-25 CS CS579A patent/CS164223B2/cs unknown
- 1973-01-25 AR AR246281A patent/AR196511A1/en active
- 1973-01-25 JP JP48010624A patent/JPS4881840A/ja active Pending
- 1973-01-25 NL NL7301122A patent/NL7301122A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2181688B1 (en) | 1976-07-02 |
| ZA73327B (en) | 1974-08-28 |
| ES410947A1 (en) | 1976-05-16 |
| DE2303021A1 (en) | 1973-08-09 |
| US3755416A (en) | 1973-08-28 |
| JPS4881840A (en) | 1973-11-01 |
| GB1374943A (en) | 1974-11-20 |
| IL41308A0 (en) | 1973-03-30 |
| IL41308A (en) | 1975-04-25 |
| HU166566B (en) | 1975-04-28 |
| SU474138A3 (en) | 1975-06-14 |
| NL7301122A (en) | 1973-07-27 |
| AU472051B2 (en) | 1976-05-13 |
| CH554847A (en) | 1974-10-15 |
| PH9470A (en) | 1975-12-16 |
| AU5122573A (en) | 1974-07-18 |
| AT320663B (en) | 1975-02-25 |
| CS164223B2 (en) | 1975-11-07 |
| FR2181688A1 (en) | 1973-12-07 |
| BE794390A (en) | 1973-07-23 |
| RO62268A (en) | 1977-10-15 |
| AR196511A1 (en) | 1974-02-06 |
| DD103892A5 (en) | 1974-02-12 |
| SE376414B (en) | 1975-05-26 |
| IE37137B1 (en) | 1977-05-11 |
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