IE37664L - 3-formylrifamycin sv derivatives - Google Patents
3-formylrifamycin sv derivativesInfo
- Publication number
- IE37664L IE37664L IE720633A IE63372A IE37664L IE 37664 L IE37664 L IE 37664L IE 720633 A IE720633 A IE 720633A IE 63372 A IE63372 A IE 63372A IE 37664 L IE37664 L IE 37664L
- Authority
- IE
- Ireland
- Prior art keywords
- formylrifamycin
- alkyl
- oximes
- mono
- derivatives
- Prior art date
Links
- BBNQHOMJRFAQBN-UPZFVJMDSA-N 3-formylrifamycin sv Chemical class OC1=C(C(O)=C2C)C3=C(O)C(C=O)=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O BBNQHOMJRFAQBN-UPZFVJMDSA-N 0.000 title abstract 2
- -1 3-formylrifamycin SV oximes Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002923 oximes Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000004858 cycloalkoxyalkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004971 nitroalkyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
1338740 3-formylrifamycin SV oximes GRUPPO LEPETIT SpA 2 May 1972 [7 June 1971 24 June 1971] 19457/72 Heading C2A The invention comprises 3-formylrifamycin SV oximes of general Formula I wherein R is alkyl of at least two carbon atoms, alkenyl, alkynyl, cycloalkyl, alkoxyalkyl, cycloalkoxyalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamyl alkyl, cyanoalkyl, nitroalkyl, aryloxyalkyl, aralkoxyalkyl, heterocycloxyalkyl, aminoalkyl, mono and di-alkylaminoalkyl, substituted benzyl, mono- and poly-aryl substituted C 2 -C 8 alkyl or alkyl substituted with 1 to 3 mono or polynuclear heterocyclic rings containing at least one heteroatom selected from O, N and S, with the exclusion of morpholine and R 1 is hydrogen or acetyl and the derivatives of the same oximes hydrogenated in the positions 16, 17, 18, 19, 28, 29. A process for preparing an oxime of Formula I comprises reacting a compound selected from 3-formylrifamycin SV, 25-desacetyl-3-formylrifamycin SV and their derivatives hydrogenated in the positions 16, 17, 18, 19, 28, 29 with about an equimolar amount of an O-substitutedhydroxylamine of the general formula RONH 2 . Therapeutic compositions comprise as the active ingredient a compound of Formula I together with a pharmaceutically acceptable carrier.
[GB1338740A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2549371 | 1971-06-07 | ||
| IT8960771A IT1045053B (en) | 1971-06-24 | 1971-06-24 | Oximes of 3-formylrifamycin - as antibiotics and dna polymerase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37664L true IE37664L (en) | 1972-12-07 |
| IE37664B1 IE37664B1 (en) | 1977-09-14 |
Family
ID=26328602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE633/72A IE37664B1 (en) | 1971-06-07 | 1972-05-11 | New 3-formylrifamycin sv derivatives |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS517679B1 (en) |
| AR (1) | AR192938A1 (en) |
| BE (1) | BE784533A (en) |
| CA (1) | CA966481A (en) |
| CH (1) | CH562248A5 (en) |
| DD (1) | DD99782A5 (en) |
| DE (1) | DE2227087C2 (en) |
| DK (1) | DK137992B (en) |
| ES (1) | ES403548A1 (en) |
| FI (1) | FI58923C (en) |
| FR (1) | FR2140534B1 (en) |
| GB (1) | GB1338740A (en) |
| HU (1) | HU163900B (en) |
| IE (1) | IE37664B1 (en) |
| IL (1) | IL39305A (en) |
| LU (1) | LU65461A1 (en) |
| NL (1) | NL153202B (en) |
| NO (1) | NO135316C (en) |
| RO (1) | RO62437A (en) |
| SU (1) | SU432721A3 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR208F (en) * | 1964-07-31 |
-
1972
- 1972-04-25 IL IL39305A patent/IL39305A/en unknown
- 1972-05-02 GB GB1945772A patent/GB1338740A/en not_active Expired
- 1972-05-04 AR AR241803A patent/AR192938A1/en active
- 1972-05-11 IE IE633/72A patent/IE37664B1/en unknown
- 1972-05-16 NO NO1747/72A patent/NO135316C/no unknown
- 1972-05-24 FI FI1449/72A patent/FI58923C/en active
- 1972-06-02 JP JP47054997A patent/JPS517679B1/ja active Pending
- 1972-06-03 DE DE2227087A patent/DE2227087C2/en not_active Expired
- 1972-06-05 CH CH827772A patent/CH562248A5/xx not_active IP Right Cessation
- 1972-06-05 CA CA143,914A patent/CA966481A/en not_active Expired
- 1972-06-05 SU SU1789260A patent/SU432721A3/en active
- 1972-06-05 LU LU65461D patent/LU65461A1/xx unknown
- 1972-06-05 DD DD163437A patent/DD99782A5/xx unknown
- 1972-06-06 RO RO7200071158A patent/RO62437A/en unknown
- 1972-06-06 HU HULE658A patent/HU163900B/hu unknown
- 1972-06-06 DK DK279572AA patent/DK137992B/en unknown
- 1972-06-06 ES ES403548A patent/ES403548A1/en not_active Expired
- 1972-06-07 BE BE784533A patent/BE784533A/en not_active IP Right Cessation
- 1972-06-07 NL NL727207698A patent/NL153202B/en not_active IP Right Cessation
- 1972-06-07 FR FR7220488A patent/FR2140534B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1338740A (en) | 1973-11-28 |
| IE37664B1 (en) | 1977-09-14 |
| NO135316C (en) | 1977-03-23 |
| AR192938A1 (en) | 1973-03-21 |
| FI58923B (en) | 1981-01-30 |
| CH562248A5 (en) | 1975-05-30 |
| NL7207698A (en) | 1972-12-11 |
| RO62437A (en) | 1978-01-15 |
| FR2140534B1 (en) | 1975-10-31 |
| ES403548A1 (en) | 1975-05-01 |
| FI58923C (en) | 1981-05-11 |
| SU432721A3 (en) | 1974-06-15 |
| DK137992C (en) | 1978-11-13 |
| IL39305A (en) | 1975-08-31 |
| DK137992B (en) | 1978-06-19 |
| BE784533A (en) | 1972-10-02 |
| DE2227087A1 (en) | 1973-04-12 |
| DD99782A5 (en) | 1973-08-20 |
| HU163900B (en) | 1973-11-28 |
| NL153202B (en) | 1977-05-16 |
| FR2140534A1 (en) | 1973-01-19 |
| IL39305A0 (en) | 1972-06-28 |
| DE2227087C2 (en) | 1982-09-02 |
| CA966481A (en) | 1975-04-22 |
| NO135316B (en) | 1976-12-13 |
| LU65461A1 (en) | 1972-10-23 |
| JPS517679B1 (en) | 1976-03-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE781878L (en) | Imidazole derivatives | |
| IE861723L (en) | Heterocyclic substituted isoxazoles | |
| ES468173A1 (en) | 14-Amino derivatives of morphine, methods of making them and analgesic compositions containing them | |
| IE43693L (en) | Androstane derivatives | |
| NO155932C (en) | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE ERYTHROMYCIN DERIVATIVES. | |
| RU94039540A (en) | Method of uterus fibrosis inhibition | |
| IE831696L (en) | TRICYCLIC AND TETRACYCLIC IMIDAZO £1,5-b| £1,4|¹BENZODIAZEPINE-1 CARBOXYLATE DERIVATES | |
| IE37664L (en) | 3-formylrifamycin sv derivatives | |
| GB1468114A (en) | Triazino 4,3-a 1,4-benzodiazepin-2 1h-ones and their pharmaceuti cal compositions | |
| ES8604960A1 (en) | 1,6-Naphthyridine derivatives, process for their preparation and medicament containing them. | |
| ES8502997A1 (en) | Substituted imidazo(1,5-a)pyridines, process for their preparation and pharmaceutical preparations containing these compounds. | |
| KR900016210A (en) | New compounds | |
| ES473900A1 (en) | Piperazino-pyrrolobenzodiazepines, methods for their preparation and pharmaceutical compositions containing them. | |
| Kier et al. | Mesoionic Ψ-oxatriazoles as hypotensive agents | |
| NO174886C (en) | Analogous Process for Preparing Therapeutically Active Pyrrolidine Derivatives | |
| ES8300776A1 (en) | Thiazolo(3,2-a)pyrimidine derivatives, their preparation and pharmaceutical compositions containing them. | |
| IE36443B1 (en) | New 3-formylrifamycin sv derivatives | |
| ES8306487A1 (en) | Imidazo-rifamycines, process for their preparation, pharmaceutical preparations containing them and their use. | |
| IE45096L (en) | Thiadiazole derivatives | |
| IE39711L (en) | Agents for regulating plant growth | |
| ES2238782T3 (en) | DERIVATIVES OF CYTOTOXIC ALCALOIDS SUCH AS ASMARINE A AND B, ISOLATED FROM A SPONGE. | |
| GB2006196A (en) | Phenylacetamides with analgesic activity | |
| ES8407035A1 (en) | Dextrogyrating isomers of 1-aza-bicyclo(2,2,2)octane derivatives, their preparation and pharmaceutical preparations containing them. | |
| GB1497827A (en) | Triazolobenzodiazepine derivatives | |
| IE43978L (en) | Pharmaceutical composition; 1,3-dialkyl-7-oxoalkylxanthines |