IE37834L - 3 - amino - pyrazolenes - (5). - Google Patents
3 - amino - pyrazolenes - (5).Info
- Publication number
- IE37834L IE37834L IE731035A IE103573A IE37834L IE 37834 L IE37834 L IE 37834L IE 731035 A IE731035 A IE 731035A IE 103573 A IE103573 A IE 103573A IE 37834 L IE37834 L IE 37834L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- alkoxy
- radical carrying
- phenyl
- phenyl radical
- Prior art date
Links
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000003282 alkyl amino group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 sulphamoyl Chemical group 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002825 nitriles Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- XSFKCGABINPZRK-UHFFFAOYSA-N 4-aminopyrazol-3-one Chemical class NC1=CN=NC1=O XSFKCGABINPZRK-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000000894 saliuretic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1391051 Aminopyrazolones BAYER AG 22 June 1973 [23 June 1972] 29785/73 Heading C2C The invention comprises compounds of the tautomeric formulae and their salts, wherein R is (a) a phenyl radical carrying one or two identical or different substituents selected from alkyl, phenyl, trifluoromethyl, trifluoromethoxy, nitro, nitrile, carbamoyl, sulphamoyl, alkylamino, fluorine, bromine and iodine radicals but cannot be a phenyl radical carrying trifluoromethyl only as one substituent, or (b) a phenyl radical carrying an annellated, branched or unbranched, saturated or unsaturated, five to seven-membered isocyclic or heterocyclic ring (the heterocyclic ring containing one or more oxygen and/or sulphur atoms); or (c) a phenyl radical carrying as substituent an SO n -alkyl group (n = 0, 1 or 2), an alkoxy group, or an -O-(CH 2 ) n -N(alkyl) 2 group (n = 2 or 3); or (d) a phenyl radical carrying two identical substituents selected from alkoxy and trifluoromethyl groups; or (e) a phenyl radical carrying two different substituents selected from alkyl, phenyl, halogen, alkoxy, trifluoromethyl, trifluoromethoxy, alkylamino, nitrile, carbamoyl, sulphamoyl, -SO n alkyl (n = 0, 1 or 2) and nitro radicals; or (f) a trichlorophenyl radical; or (g) a naphthyl radical carrying one or two identical or different substituents selected from halogen atoms and alkyl groups; or (h) an unsubstituted #-naphthyl, anthryl or phenanthryl radical. These compounds are prepared by reacting RCH 2 NHNH 2 with CNCH 2 COX or where X is OH, alkoxy, aralkoxy, NH 2 or alkylamino, and Y is alkoxy, aryloxy, aralkoxy, alkylmercapto, aralkylmercapto or NH 2 . Therapeutic compositions having diuretic, saluretic and antihypertensive activity comprise compounds of the above formulae, and may be administered orally, parenterally, rectally, topically or by means of a spray.
[GB1391051A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2230792A DE2230792A1 (en) | 1972-06-23 | 1972-06-23 | 3-AMINO-PYRAZOLONE- (5), METHOD FOR MANUFACTURING AND USING IT AS A MEDICINAL PRODUCT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37834L true IE37834L (en) | 1973-12-23 |
| IE37834B1 IE37834B1 (en) | 1977-10-26 |
Family
ID=5848604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1035/73A IE37834B1 (en) | 1972-06-23 | 1973-06-22 | 3-amino-pyrazolones-(5),processes for their manufacture and their use as medicines |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS4962463A (en) |
| KR (1) | KR780000147B1 (en) |
| AR (1) | AR205329A1 (en) |
| AT (1) | AT323735B (en) |
| BE (1) | BE801228A (en) |
| BG (1) | BG22819A3 (en) |
| CA (1) | CA1017752A (en) |
| CH (1) | CH592632A5 (en) |
| DD (1) | DD109874A5 (en) |
| DE (1) | DE2230792A1 (en) |
| DK (1) | DK133468C (en) |
| EG (1) | EG11039A (en) |
| ES (1) | ES416167A1 (en) |
| FR (1) | FR2189072B1 (en) |
| GB (1) | GB1391051A (en) |
| HK (1) | HK11276A (en) |
| HU (1) | HU168358B (en) |
| IE (1) | IE37834B1 (en) |
| IL (1) | IL42560A (en) |
| LU (1) | LU67854A1 (en) |
| NL (1) | NL7308575A (en) |
| NO (1) | NO137196C (en) |
| OA (1) | OA04432A (en) |
| PH (1) | PH11606A (en) |
| PL (1) | PL87665B1 (en) |
| RO (1) | RO71819A (en) |
| SE (1) | SE401181B (en) |
| SU (1) | SU472503A3 (en) |
| ZA (1) | ZA734244B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE30420E (en) * | 1973-04-17 | 1980-10-21 | Bayer Aktiengesellschaft | Pyrazol-5-ones |
| DE2319278C2 (en) * | 1973-04-17 | 1986-02-20 | Bayer Ag, 5090 Leverkusen | Pharmaceutical agent |
| DE3436383A1 (en) * | 1984-10-04 | 1986-04-10 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING PYRAZOLONE DERIVATIVES |
-
1972
- 1972-06-23 DE DE2230792A patent/DE2230792A1/en not_active Withdrawn
-
1973
- 1973-06-06 RO RO7375048A patent/RO71819A/en unknown
- 1973-06-19 BG BG023919A patent/BG22819A3/en unknown
- 1973-06-20 IL IL42560A patent/IL42560A/en unknown
- 1973-06-20 AT AT544673A patent/AT323735B/en not_active IP Right Cessation
- 1973-06-20 SU SU1938995A patent/SU472503A3/en active
- 1973-06-20 CH CH897973A patent/CH592632A5/xx not_active IP Right Cessation
- 1973-06-20 SE SE7308721A patent/SE401181B/en unknown
- 1973-06-20 NL NL7308575A patent/NL7308575A/xx not_active Application Discontinuation
- 1973-06-21 EG EG235/73A patent/EG11039A/en active
- 1973-06-21 JP JP48069262A patent/JPS4962463A/ja active Pending
- 1973-06-21 LU LU67854A patent/LU67854A1/xx unknown
- 1973-06-21 DD DD171728A patent/DD109874A5/xx unknown
- 1973-06-21 BE BE132533A patent/BE801228A/en unknown
- 1973-06-22 FR FR7322955A patent/FR2189072B1/fr not_active Expired
- 1973-06-22 HU HUBA2942A patent/HU168358B/hu unknown
- 1973-06-22 AR AR248701A patent/AR205329A1/en active
- 1973-06-22 NO NO2618/73A patent/NO137196C/en unknown
- 1973-06-22 ES ES416167A patent/ES416167A1/en not_active Expired
- 1973-06-22 CA CA174,778A patent/CA1017752A/en not_active Expired
- 1973-06-22 IE IE1035/73A patent/IE37834B1/en unknown
- 1973-06-22 GB GB2978573A patent/GB1391051A/en not_active Expired
- 1973-06-22 DK DK349573A patent/DK133468C/en active
- 1973-06-22 ZA ZA734244A patent/ZA734244B/en unknown
- 1973-06-22 OA OA54946A patent/OA04432A/en unknown
- 1973-06-22 PL PL1973163511A patent/PL87665B1/pl unknown
- 1973-06-23 KR KR7301005A patent/KR780000147B1/en not_active Expired
-
1975
- 1975-01-03 PH PH16674A patent/PH11606A/en unknown
-
1976
- 1976-03-04 HK HK112/76*UA patent/HK11276A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH592632A5 (en) | 1977-10-31 |
| BE801228A (en) | 1973-12-21 |
| GB1391051A (en) | 1975-04-16 |
| IL42560A0 (en) | 1973-08-29 |
| CA1017752A (en) | 1977-09-20 |
| NL7308575A (en) | 1973-12-27 |
| EG11039A (en) | 1977-01-31 |
| AR205329A1 (en) | 1976-04-30 |
| PH11606A (en) | 1978-04-12 |
| FR2189072B1 (en) | 1977-09-09 |
| IL42560A (en) | 1977-05-31 |
| FR2189072A1 (en) | 1974-01-25 |
| NO137196B (en) | 1977-10-10 |
| AT323735B (en) | 1975-07-25 |
| LU67854A1 (en) | 1973-08-30 |
| IE37834B1 (en) | 1977-10-26 |
| NO137196C (en) | 1978-01-18 |
| SU472503A3 (en) | 1975-05-30 |
| SE401181B (en) | 1978-04-24 |
| JPS4962463A (en) | 1974-06-17 |
| RO71819A (en) | 1981-01-30 |
| DK133468C (en) | 1976-10-18 |
| OA04432A (en) | 1980-03-15 |
| HU168358B (en) | 1976-04-28 |
| ZA734244B (en) | 1974-06-26 |
| AU5705173A (en) | 1974-12-19 |
| DK133468B (en) | 1976-05-24 |
| HK11276A (en) | 1976-03-12 |
| ES416167A1 (en) | 1976-03-01 |
| KR780000147B1 (en) | 1978-04-19 |
| PL87665B1 (en) | 1976-07-31 |
| BG22819A3 (en) | 1977-04-20 |
| DE2230792A1 (en) | 1974-01-17 |
| DD109874A5 (en) | 1974-11-20 |
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