IE37842L - Bis-guanide-phosphorus-containing oral compositions - Google Patents
Bis-guanide-phosphorus-containing oral compositionsInfo
- Publication number
- IE37842L IE37842L IE104873A IE104873A IE37842L IE 37842 L IE37842 L IE 37842L IE 104873 A IE104873 A IE 104873A IE 104873 A IE104873 A IE 104873A IE 37842 L IE37842 L IE 37842L
- Authority
- IE
- Ireland
- Prior art keywords
- hydrogen
- radical
- phosphorus
- compound
- represent
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 229910052698 phosphorus Inorganic materials 0.000 title abstract 4
- 239000011574 phosphorus Substances 0.000 title abstract 4
- -1 C1-12 alkyl radical Chemical class 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000002272 anti-calculus Effects 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 150000004287 bisbiguanides Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 239000000551 dentifrice Substances 0.000 abstract 1
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 abstract 1
- GWBBVOVXJZATQQ-UHFFFAOYSA-L etidronate disodium Chemical group [Na+].[Na+].OP(=O)([O-])C(O)(C)P(O)([O-])=O GWBBVOVXJZATQQ-UHFFFAOYSA-L 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 abstract 1
- 239000002324 mouth wash Substances 0.000 abstract 1
- 229940051866 mouthwash Drugs 0.000 abstract 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003568 thioethers Chemical group 0.000 abstract 1
- 229940100613 topical solution Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Medicinal Preparation (AREA)
Abstract
1432487 Oral compositions PROCTER & GAMBLE CO 29 June 1973 [30 June 1972 6 March 1973] 31073/73 Heading A5B A composition for treating the oral cavity comprises (a) from 0.01-2.5% by weight of a bis-biguanide of formula: wherein A and A' each represent (1) a substituted or unsubstituted phenyl radical; or (2) a C1-12 alkyl radical; or (3) a C4-12 alicyclic radioal; wherein X and X' each represent C1-3 alkylene radical; wherein z and z' each represent 0 or 1; wherein R and R' each represent hydrogen, a C1-12 alkyl radical or a C7-12 aralkyl radical; wherein n is 2-12; and wherein the -(CH2)nchain can be interrupted by up to 5 other thioether, phenyl or naphthyl moieties; or the pharmaceutically acceptable salts thereof; and (b) a composition comprising from 0.01-10% by weight of a water-soluble phosphorus-containing anticalculus compound in excess over that which reacts with the bis-guanide compound. The anti-calculus compound is selected from wherein R1 and R2 are hydrogen or CH2OH; n is 3-10; R3 is hydrogen, a C1-20 alkyl radical, a C2-20 alkenyl radical, phenyl, naphthyl, phenylethenyl, benzyl, halogen, amino, dimethyl amino, diethylamino, N-hydroxy-N- ethylamino, acetylamino, -CH2CO2H, -CH2 PO3H2, -CH(PO3H2)OH, or -CH2CH (PO3H2)2; and R4 is hydrogen, C1-4 alkyl, amino, benzyl, halogen, hydroxyl, -CH2CO2H, -CH2PO3H2, or -CH2CH2PO3H2; wherein R5-10 are hydrogen or C1-4 alkyl; wherein n is 3-9; wherein X and Y are each hydrogen or hydroxy; or a pharmaceutically acceptable salt thereof; or the condensation products of ammonia and phosphorus pentoxide, comprising the compounds The cavity may be treated first with the bisbiguanide compound and then with the phosphorus-containing anti-calculus compound. The composition may also contain a water-soluble fluoride. The preferred bis-biguanide is [1, 6- di(N1, N1'-p-chlorophenyl-diguanido-N5, N5') hexane] digluconate. The phosphorus-containing anti-calculus agent is disodium ethane-1- hydroxy-1, 1-diphosphonate. The composition may be used as a dentifrice, mouthwash. prophylaxis paste or a topical solution.
[GB1432487A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26781672A | 1972-06-30 | 1972-06-30 | |
| US33847273A | 1973-03-06 | 1973-03-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37842L true IE37842L (en) | 1973-12-30 |
| IE37842B1 IE37842B1 (en) | 1977-10-26 |
Family
ID=26952666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE104873A IE37842B1 (en) | 1972-06-30 | 1973-06-25 | Oral compositions for plaque caries and calculus retardation with reduced staining tendencies |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS4966838A (en) |
| AT (1) | AT333969B (en) |
| AU (1) | AU474403B2 (en) |
| CA (1) | CA1001554A (en) |
| CH (1) | CH595100A5 (en) |
| DE (1) | DE2332383A1 (en) |
| DK (1) | DK135789B (en) |
| ES (1) | ES416478A1 (en) |
| FR (1) | FR2190459B1 (en) |
| GB (1) | GB1432487A (en) |
| IE (1) | IE37842B1 (en) |
| NL (1) | NL7309090A (en) |
| SE (1) | SE403963B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1458476A (en) * | 1975-06-23 | 1977-12-08 | Procter & Gamble | Bis-biguanide compounds |
| SE431285B (en) * | 1976-08-16 | 1984-01-30 | Colgate Palmolive Co | MUNVARDS COMPOSITION CONTAINING A PHOSPHONE SOCIETY, FOR REDUCING MISSING DIFFERENCE PICTURED BY AN INCLUDING NITROGEN ANTIBACTERIAL PLAQUE |
| JPS5840523B2 (en) * | 1976-08-26 | 1983-09-06 | 松風陶歯製造株式会社 | Dental primer composition |
| IT1201087B (en) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | PHARMACOLOGICALLY ACTIVE BIPPHOSPHONES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS |
| US4961923A (en) * | 1988-02-19 | 1990-10-09 | Dentsply Management Corp. | Irrigants for use in scaling and/or lavage apparatus |
| US6190642B1 (en) | 1988-02-19 | 2001-02-20 | Dentsply Research & Development Corp. | Irrigating and lavage compositions |
| US5438076A (en) * | 1988-05-03 | 1995-08-01 | Perio Products, Ltd. | Liquid polymer composition, and method of use |
| US6214320B1 (en) | 1990-10-09 | 2001-04-10 | Colgate-Palmolive Company | Oral compositions containing anticalculus and antiplaque agents |
| AU2008349846B2 (en) | 2008-02-08 | 2012-05-31 | Colgate-Palmolive Company | Arginine salts and their uses for the treatment of illnesses in the oral cavity |
| BR112016005528B1 (en) | 2013-09-13 | 2023-03-28 | 3M Innovative Properties Company | ANTISEPTIC COMPOSITION COMPRISING MULTIVALENT CATIONIC ANTISEPTIC |
| CN111138660B (en) * | 2019-12-20 | 2020-12-08 | 浙江大学 | A kind of preparation method of fluorinated polyhexamethylene biguanide |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR6568736D0 (en) * | 1964-04-09 | 1973-08-14 | Drug Inc Sterling | PROCESS TO PREPARE A BISGUANIDE |
| IT1002501B (en) * | 1965-05-03 | 1976-05-20 | Colgate Palmolive Co | TOOTHPASTE COMPOSITIONS |
| BE722631A (en) * | 1965-12-08 | 1969-04-21 | ||
| US3639569A (en) * | 1968-02-19 | 1972-02-01 | Procter & Gamble | Oral compositions for calculus retardation |
| US3562385A (en) * | 1968-12-23 | 1971-02-09 | Merck & Co Inc | Dental antiplaque and anticalculus compositions |
| BE730888A (en) * | 1969-04-01 | 1969-09-15 |
-
1973
- 1973-06-25 IE IE104873A patent/IE37842B1/en unknown
- 1973-06-26 DE DE19732332383 patent/DE2332383A1/en active Pending
- 1973-06-28 AU AU57451/73A patent/AU474403B2/en not_active Expired
- 1973-06-28 DK DK358773A patent/DK135789B/en unknown
- 1973-06-28 SE SE7309141A patent/SE403963B/en unknown
- 1973-06-29 FR FR7324040A patent/FR2190459B1/fr not_active Expired
- 1973-06-29 CH CH947673A patent/CH595100A5/xx not_active IP Right Cessation
- 1973-06-29 GB GB3107373A patent/GB1432487A/en not_active Expired
- 1973-06-29 CA CA175,292A patent/CA1001554A/en not_active Expired
- 1973-06-29 NL NL7309090A patent/NL7309090A/xx not_active Application Discontinuation
- 1973-06-29 AT AT575373A patent/AT333969B/en not_active IP Right Cessation
- 1973-06-30 JP JP48074329A patent/JPS4966838A/ja active Pending
- 1973-06-30 ES ES416478A patent/ES416478A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2190459A1 (en) | 1974-02-01 |
| JPS4966838A (en) | 1974-06-28 |
| DK135789C (en) | 1977-11-28 |
| CA1001554A (en) | 1976-12-14 |
| ATA575373A (en) | 1976-04-15 |
| DK135789B (en) | 1977-06-27 |
| AU5745173A (en) | 1975-01-09 |
| DE2332383A1 (en) | 1974-01-10 |
| AT333969B (en) | 1976-12-27 |
| NL7309090A (en) | 1974-01-02 |
| AU474403B2 (en) | 1976-07-22 |
| ES416478A1 (en) | 1976-06-01 |
| SE403963B (en) | 1978-09-18 |
| FR2190459B1 (en) | 1977-04-15 |
| GB1432487A (en) | 1976-04-14 |
| CH595100A5 (en) | 1978-01-31 |
| IE37842B1 (en) | 1977-10-26 |
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