IE37949L - Tetrazolylacetate esters and acids. - Google Patents
Tetrazolylacetate esters and acids.Info
- Publication number
- IE37949L IE37949L IE731268A IE126873A IE37949L IE 37949 L IE37949 L IE 37949L IE 731268 A IE731268 A IE 731268A IE 126873 A IE126873 A IE 126873A IE 37949 L IE37949 L IE 37949L
- Authority
- IE
- Ireland
- Prior art keywords
- alkali metal
- radical
- hydrocarbon
- acid
- tetrazolylacetate
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title abstract 4
- 150000007513 acids Chemical class 0.000 title abstract 3
- -1 hydrocarbon radical Chemical class 0.000 abstract 6
- 239000004215 Carbon black (E152) Substances 0.000 abstract 4
- 229910052783 alkali metal Inorganic materials 0.000 abstract 4
- 229930195733 hydrocarbon Natural products 0.000 abstract 4
- GRWAIJBHBCCLGS-UHFFFAOYSA-N 2-(tetrazol-1-yl)acetic acid Chemical compound OC(=O)CN1C=NN=N1 GRWAIJBHBCCLGS-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 150000002430 hydrocarbons Chemical class 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000006564 (C4-C8) cycloalkyl group Chemical group 0.000 abstract 1
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Chemical compound C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 abstract 1
- PPXUUPXQWDQNGO-UHFFFAOYSA-N 2-azidoacetic acid Chemical compound OC(=O)CN=[N+]=[N-] PPXUUPXQWDQNGO-UHFFFAOYSA-N 0.000 abstract 1
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical compound [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001264 acyl cyanides Chemical class 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 abstract 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000005023 xylyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1435809 1 - H - Tetrazole - -1 - acetate esters and acids ELI LILLY & CO 13 Aug 1973 [14 Aug 1972] 38132/73 Heading C2C Novel tetrazolylacetate esters and acids having the general formula wherein R is a (C 1 -C 12 ) hydrocarbon radical free from aliphatic unsaturation, a (C 1 -C 12 ) hydrocarbon -O- radical free from aliphatic unsaturation or an -O- alkali metal radical; and R<SP>1</SP> is hydrogen, an alkali metal cation or a (C 1 -C 12 ) alkyl, (C 4 -C 8 ) cycloalkyl, phenyl, behzyl, p-nitrophenyl, p-nitrobenzyl, 2,2,2-trichloroethyl or phenacyl radical, as well those compounds of the above formula wherein R<SP>1</SP> may also be tolyl, xylyl or phenylethyl, are prepared by reacting an acyl cyanide of the formula (II) with an azidoacetic acid or ester thereof having the formula (III) at a temperature of from 80‹ to 135‹ C. The resultant tetrazolylacetate ester may be further reacted with either (a) an alcoholic alkali metal hydroxide to form the corresponding alkali metal salt, (b) a base to remove the 5-acyl substituent and form the alkali metal salt of 1-tetrazoleacetic acid, provided that R is a (C 1 -C 12 ) hydrocarbon radical, or (c) with an acid to remove the 5-acyl substituent and form the 1-tetrazoleacetic acid, provided that R is a (C 1 -C 12 ) hydrocarbon -O- radical.
[GB1435809A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28062572A | 1972-08-14 | 1972-08-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37949L true IE37949L (en) | 1974-02-14 |
| IE37949B1 IE37949B1 (en) | 1977-11-23 |
Family
ID=23073908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1268/73A IE37949B1 (en) | 1972-08-14 | 1973-07-25 | 1 h-tetrazole-1-acetate esters and acids and processes therefor |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5821628B2 (en) |
| KR (1) | KR780000071B1 (en) |
| AR (1) | AR195626A1 (en) |
| AT (1) | AT329555B (en) |
| AU (1) | AU476519B2 (en) |
| BE (1) | BE803520A (en) |
| BG (1) | BG21220A3 (en) |
| CA (1) | CA998397A (en) |
| CH (1) | CH588475A5 (en) |
| CS (1) | CS179425B2 (en) |
| DD (1) | DD110272A5 (en) |
| DE (1) | DE2340409A1 (en) |
| ES (1) | ES417837A1 (en) |
| FR (1) | FR2196336B1 (en) |
| GB (1) | GB1435809A (en) |
| HU (1) | HU166844B (en) |
| IE (1) | IE37949B1 (en) |
| IL (1) | IL42843A (en) |
| NL (1) | NL179380C (en) |
| PH (1) | PH10552A (en) |
| PL (1) | PL89385B1 (en) |
| RO (1) | RO73460A (en) |
| SE (1) | SE402913B (en) |
| SU (1) | SU576935A3 (en) |
| YU (1) | YU36513B (en) |
| ZA (1) | ZA735075B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854015B2 (en) * | 1978-12-14 | 1980-10-09 | Dynamit Nobel Ag, 5210 Troisdorf | Process for the preparation of! H-TetrazoI-1-acetic acids and certain esters thereof |
| WO2010103783A1 (en) * | 2009-03-11 | 2010-09-16 | 日本曹達株式会社 | Process for preparation of 1-alkyl-5-benzoyl-1h-tetrazole derivatives |
| CN114085193A (en) * | 2021-11-20 | 2022-02-25 | 九江中星医药化工有限公司 | Method for preparing 1H-tetrazoleacetic acid and derivatives thereof by aqueous phase method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD70880A (en) * |
-
1973
- 1973-07-25 IE IE1268/73A patent/IE37949B1/en unknown
- 1973-07-25 ZA ZA00735075A patent/ZA735075B/en unknown
- 1973-07-26 AU AU58575/73A patent/AU476519B2/en not_active Expired
- 1973-07-27 IL IL42843A patent/IL42843A/en unknown
- 1973-08-02 CA CA177,995A patent/CA998397A/en not_active Expired
- 1973-08-03 PH PH14880A patent/PH10552A/en unknown
- 1973-08-07 YU YU02148/73A patent/YU36513B/en unknown
- 1973-08-09 DE DE19732340409 patent/DE2340409A1/en active Granted
- 1973-08-10 AT AT703773A patent/AT329555B/en not_active IP Right Cessation
- 1973-08-10 BE BE1005292A patent/BE803520A/en unknown
- 1973-08-10 HU HUEI490A patent/HU166844B/hu unknown
- 1973-08-13 PL PL1973164647A patent/PL89385B1/pl unknown
- 1973-08-13 SE SE7311051A patent/SE402913B/en unknown
- 1973-08-13 GB GB3813273A patent/GB1435809A/en not_active Expired
- 1973-08-13 KR KR7301319A patent/KR780000071B1/en not_active Expired
- 1973-08-13 SU SU7301955734A patent/SU576935A3/en active
- 1973-08-13 ES ES417837A patent/ES417837A1/en not_active Expired
- 1973-08-14 BG BG024317A patent/BG21220A3/en unknown
- 1973-08-14 AR AR249586A patent/AR195626A1/en active
- 1973-08-14 FR FR7329649A patent/FR2196336B1/fr not_active Expired
- 1973-08-14 JP JP48091225A patent/JPS5821628B2/en not_active Expired
- 1973-08-14 RO RO7375793A patent/RO73460A/en unknown
- 1973-08-14 CS CS7300005736A patent/CS179425B2/en unknown
- 1973-08-14 DD DD172890A patent/DD110272A5/xx unknown
- 1973-08-14 NL NLAANVRAGE7311222,A patent/NL179380C/en not_active IP Right Cessation
- 1973-08-14 CH CH1171373A patent/CH588475A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2340409C2 (en) | 1988-03-17 |
| ES417837A1 (en) | 1976-02-16 |
| AT329555B (en) | 1976-05-25 |
| NL7311222A (en) | 1974-02-18 |
| ZA735075B (en) | 1975-03-26 |
| IL42843A0 (en) | 1976-01-30 |
| DE2340409A1 (en) | 1974-02-28 |
| NL179380B (en) | 1986-04-01 |
| CA998397A (en) | 1976-10-12 |
| HU166844B (en) | 1975-06-28 |
| FR2196336A1 (en) | 1974-03-15 |
| RO73460A (en) | 1982-09-09 |
| BG21220A3 (en) | 1976-03-20 |
| AR195626A1 (en) | 1973-10-23 |
| CS179425B2 (en) | 1977-10-31 |
| AU476519B2 (en) | 1976-09-23 |
| ATA703773A (en) | 1975-08-15 |
| SU576935A3 (en) | 1977-10-15 |
| AU5857573A (en) | 1975-01-30 |
| NL179380C (en) | 1986-09-01 |
| JPS4975580A (en) | 1974-07-20 |
| SE402913B (en) | 1978-07-24 |
| GB1435809A (en) | 1976-05-19 |
| IL42843A (en) | 1976-12-31 |
| IE37949B1 (en) | 1977-11-23 |
| PH10552A (en) | 1977-06-08 |
| CH588475A5 (en) | 1977-06-15 |
| PL89385B1 (en) | 1976-11-30 |
| JPS5821628B2 (en) | 1983-05-02 |
| FR2196336B1 (en) | 1977-02-25 |
| BE803520A (en) | 1974-02-11 |
| YU214873A (en) | 1982-02-25 |
| KR780000071B1 (en) | 1978-03-30 |
| DD110272A5 (en) | 1974-12-12 |
| YU36513B (en) | 1984-02-29 |
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