IE38515L - Cyclopentane (prostanoic acid) derivatives - Google Patents

Cyclopentane (prostanoic acid) derivatives

Info

Publication number
IE38515L
IE38515L IE732066A IE206673A IE38515L IE 38515 L IE38515 L IE 38515L IE 732066 A IE732066 A IE 732066A IE 206673 A IE206673 A IE 206673A IE 38515 L IE38515 L IE 38515L
Authority
IE
Ireland
Prior art keywords
trimethylsilyloxy
trans
cis
epi
trimethylsilyl
Prior art date
Application number
IE732066A
Other versions
IE38515B1 (en
Original Assignee
Ici Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Ltd filed Critical Ici Ltd
Publication of IE38515L publication Critical patent/IE38515L/en
Publication of IE38515B1 publication Critical patent/IE38515B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

1402035 Silylated prostadienoates IMPERIAL CHEMICAL INDUSTRIES Ltd 13 Nov 1973 [7 Dec 1972] 56501/72 Heading C3S [Also in Divisions C2 and A5] Trimethylsilyl 16 - (3 - chlorophenoxy)- 9,11α,15 - tri(trimethylsilyloxy) - 17,18,19,20- tetranor - 5 - cis,13 - trans - 12 - epi - prostadienoate, trimethylsilyl 16 - (3 - chlorophenoxy) - 9 - methoxyimino - 11α,15 - di(trimethylsilyloxy) - 17,18,19,20 - tetranor - 5 - cis,13- trans - 12 - epi - prostadienoate, trimethylsilyl 16 - (3 - chlorophenoxy) - 2 - methyl - 9 - methoxyimino - - 11α,15 - di(trimethylsilyloxy)- 17,18,19,20 - tetranot - 5 - cis,13 trans - 12- epi - prostadienoate, trimethylsilyl 9,11α,15- tri(trimethylsilyloxy) - 5 - cis,13 - trans - 12- epi - prostadienoate, 9 - methoxyimino - 11α, 15- di(trimethylsilyloxy) - 5 - cis,13 - trans - 12 - epiprostadienoate, trimethylsilyl 2 - methyl - 9α,- 11α,15 - tri(trimethylsilyloxy) - 5 - cis,13- trans - 12 - epi - prostadienoate, trimethylsilyl 9 - methoxyimino - 2 - methyl - 11α,15 - di- (trimethylsilyloxy) - 5 - cis,13 - trans - 12 - epiprostadienoate, trimethylsilyl 20 - ethyl- 9α,11α,15 - tri(trimethylsilyloxy) - 5 - cis,13- trans - 12 - epi - prostadienoate, trimethysilyl 9 - methoxyimino - 11α,15 - di(trimethylsilyloxy) - 13 - trans - 12 - epi - prostenoate, trimethylsilyl 9α,11α,15 - tri(trimethylsilyloxy)- 13 - trans - 12 - epi - prostenoate, trimethylsilyl 16 - phenyl - 9α,11α,15 - tri(trimethylsilyloxy)- 17,18,19,20 - tetranor - 5 - cis,13 - trans - 12- epi - prostadienoate, 9 - methoxyimino - 16- phenyl - 11α,15 - di(trimethylsilyloxy) - 17,18,- 19, 20 - tetranor - 5 - cis,13 - trans - 12 - epiprostadienoate, trimethylsilyl 16 - (2 - naphthyloxy) - 9α,11α,15 - tri(trimethylsilyloxy)- 17,18,19,20 - tetranor - 5 - cis,13 - trans - 12- epi - prostadienoate and trimethylsilyl 16- (2 - naphthyloxy) - 11α,15 - di(trimethylsilyloxy) - 17,18,19,20 - tetranor - 5 - cis,13 - trans- 12 - epi - prostadienoate are prepared by standard methods. [GB1402035A]
IE2066/73A 1972-12-07 1973-11-15 Cyclopentane derivatives IE38515B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5650172A GB1402035A (en) 1972-12-07 1972-12-07 Cyclopentane derivatives

Publications (2)

Publication Number Publication Date
IE38515L true IE38515L (en) 1974-06-07
IE38515B1 IE38515B1 (en) 1978-03-29

Family

ID=10476784

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2066/73A IE38515B1 (en) 1972-12-07 1973-11-15 Cyclopentane derivatives

Country Status (13)

Country Link
JP (1) JPS5024252A (en)
AU (1) AU473283B2 (en)
BE (1) BE808398A (en)
CA (1) CA1016940A (en)
CH (1) CH605725A5 (en)
DE (1) DE2360893A1 (en)
ES (1) ES421274A1 (en)
FR (1) FR2209569B1 (en)
GB (1) GB1402035A (en)
IE (1) IE38515B1 (en)
LU (1) LU68940A1 (en)
NL (1) NL7316508A (en)
ZA (1) ZA738797B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0144459A1 (en) * 1983-12-09 1985-06-19 Dr. Willmar Schwabe GmbH & Co. Prostaglandins, their preparation and pharmaceutical compositions
JPS6240987A (en) * 1985-08-20 1987-02-21 Nippon Steel Corp Energy beam welding method
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5972991A (en) 1992-09-21 1999-10-26 Allergan Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
WO2010102078A1 (en) 2009-03-04 2010-09-10 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US7851504B2 (en) 2005-03-16 2010-12-14 Allergan, Inc. Enhanced bimatoprost ophthalmic solution
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure

Also Published As

Publication number Publication date
DE2360893A1 (en) 1974-06-12
ES421274A1 (en) 1976-04-16
NL7316508A (en) 1974-06-11
IE38515B1 (en) 1978-03-29
LU68940A1 (en) 1974-02-12
AU473283B2 (en) 1976-06-17
JPS5024252A (en) 1975-03-15
BE808398A (en) 1974-06-07
AU6279773A (en) 1975-11-27
FR2209569B1 (en) 1978-07-28
CH605725A5 (en) 1978-10-13
GB1402035A (en) 1975-08-06
CA1016940A (en) 1977-09-06
FR2209569A1 (en) 1974-07-05
ZA738797B (en) 1974-07-31

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