IE38539L - Des-lys29-ala30-insulin. - Google Patents
Des-lys29-ala30-insulin.Info
- Publication number
- IE38539L IE38539L IE732122A IE212273A IE38539L IE 38539 L IE38539 L IE 38539L IE 732122 A IE732122 A IE 732122A IE 212273 A IE212273 A IE 212273A IE 38539 L IE38539 L IE 38539L
- Authority
- IE
- Ireland
- Prior art keywords
- insulin
- des
- lys
- ala
- protease
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 229940125396 insulin Drugs 0.000 title abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 101001011741 Bos taurus Insulin Proteins 0.000 abstract 1
- 102000005593 Endopeptidases Human genes 0.000 abstract 1
- 108010059378 Endopeptidases Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- QOOWRKBDDXQRHC-BQBZGAKWSA-N L-lysyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN QOOWRKBDDXQRHC-BQBZGAKWSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 241001544324 Myxobacter Species 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 108010005991 Pork Regular Insulin Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 101710180316 Protease 2 Proteins 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 229920005654 Sephadex Polymers 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- IXIBAKNTJSCKJM-BUBXBXGNSA-N bovine insulin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 IXIBAKNTJSCKJM-BUBXBXGNSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
- 230000002608 insulinlike Effects 0.000 abstract 1
- 239000002808 molecular sieve Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920002401 polyacrylamide Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1426061 Insulins IMPERIAL CHEMICAL INDUSTRIES Ltd 20 Nov 1973 [28 Dec 1972] 59742/72 Heading C3H The novel compounds, des-Lys<SP>29</SP>-Ala<SP>30</SP>-bovine insulin and des-Lys<SP>29</SP>-Ala<SP>30</SP>-porcine insulin are prepared by treating bovine or porcine insulin in an aqueous medium with a lysine specific amino - endopeptidase, e.g. AM - protease or myxobacter AL-I protease II (both defined), and separating the desired insulin from the remaining enzyme and lysyl-alanine, e.g. by means of a molecular sieve such as a crosslinked dextran gel or a polyacrylamide gel. Pharmaceutical compositions having insulin-like activity, for parenteral administration, comprise one of the above novel compounds together with a pharmaceutically acceptable diluent or solvent.
[GB1426061A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5974272 | 1972-12-28 | ||
| GB438773*[A GB1426061A (en) | 1972-12-28 | 1973-01-29 | Polypeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38539L true IE38539L (en) | 1974-06-28 |
| IE38539B1 IE38539B1 (en) | 1978-04-12 |
Family
ID=26239087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2122/73A IE38539B1 (en) | 1972-12-28 | 1973-11-22 | Polypeptides |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3903069A (en) |
| JP (1) | JPS5726760B2 (en) |
| AT (1) | AT348152B (en) |
| AU (1) | AU474971B2 (en) |
| CA (1) | CA1009974A (en) |
| CH (1) | CH599927A5 (en) |
| DD (1) | DD110490A5 (en) |
| DE (1) | DE2364883C2 (en) |
| ES (1) | ES421864A1 (en) |
| FR (1) | FR2212136B1 (en) |
| GB (1) | GB1426061A (en) |
| HU (1) | HU170437B (en) |
| IE (1) | IE38539B1 (en) |
| IL (1) | IL43751A (en) |
| LU (1) | LU69075A1 (en) |
| NL (1) | NL7317159A (en) |
| PL (1) | PL91158B1 (en) |
| SE (1) | SE404600B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO153061C (en) * | 1979-04-13 | 1986-01-08 | Shionogi & Co | PROCEDURE FOR THE PREPARATION OF A B30 THREON INSULIN |
| JPS55138391A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | New synthetic method of peptide derivative |
| WO1983002772A1 (en) * | 1982-02-08 | 1983-08-18 | Robin Ewart Offord | An improved method for preparing human insulin from non-human insulin |
| DE3209184A1 (en) * | 1982-03-13 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | METHOD FOR CONVERTING PRAEPROINSULIN ANALOGS TO INSULINES |
| GB8610551D0 (en) * | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
| US6673347B1 (en) * | 1986-04-30 | 2004-01-06 | Gryphon Therapeutics | Polypeptide and protein derivatives and process for their preparation |
| PH23446A (en) * | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
| US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| AU641631B2 (en) * | 1988-12-23 | 1993-09-30 | Novo Nordisk A/S | Human insulin analogues |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH471220A (en) * | 1964-05-09 | 1969-04-15 | Roehm & Haas Gmbh | Process for the production of an aminopeptidase which cleaves L-leucine amide, hypertensin and oxytocin |
-
1973
- 1973-01-29 GB GB438773*[A patent/GB1426061A/en not_active Expired
- 1973-11-22 IE IE2122/73A patent/IE38539B1/en unknown
- 1973-11-23 CA CA186,556A patent/CA1009974A/en not_active Expired
- 1973-11-28 AU AU62979/73A patent/AU474971B2/en not_active Expired
- 1973-11-30 US US420573A patent/US3903069A/en not_active Expired - Lifetime
- 1973-12-04 IL IL43751A patent/IL43751A/en unknown
- 1973-12-14 CH CH1759373A patent/CH599927A5/xx not_active IP Right Cessation
- 1973-12-14 NL NL7317159A patent/NL7317159A/xx unknown
- 1973-12-15 PL PL1973167350A patent/PL91158B1/pl unknown
- 1973-12-20 SE SE7317256A patent/SE404600B/en unknown
- 1973-12-21 DD DD175618A patent/DD110490A5/xx unknown
- 1973-12-26 JP JP744631A patent/JPS5726760B2/ja not_active Expired
- 1973-12-27 AT AT1084473A patent/AT348152B/en not_active IP Right Cessation
- 1973-12-27 FR FR7346550A patent/FR2212136B1/fr not_active Expired
- 1973-12-27 LU LU69075A patent/LU69075A1/xx unknown
- 1973-12-28 DE DE2364883A patent/DE2364883C2/en not_active Expired
- 1973-12-28 HU HUIE605A patent/HU170437B/hu unknown
- 1973-12-28 ES ES421864A patent/ES421864A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU6297973A (en) | 1975-05-29 |
| DE2364883A1 (en) | 1974-07-04 |
| NL7317159A (en) | 1974-07-02 |
| LU69075A1 (en) | 1974-03-07 |
| GB1426061A (en) | 1976-02-25 |
| JPS4994698A (en) | 1974-09-09 |
| JPS5726760B2 (en) | 1982-06-07 |
| FR2212136B1 (en) | 1978-01-06 |
| AT348152B (en) | 1979-02-12 |
| CH599927A5 (en) | 1978-06-15 |
| SE404600B (en) | 1978-10-16 |
| IL43751A (en) | 1977-01-31 |
| IE38539B1 (en) | 1978-04-12 |
| IL43751A0 (en) | 1974-03-14 |
| PL91158B1 (en) | 1977-02-28 |
| ATA1084473A (en) | 1978-06-15 |
| US3903069A (en) | 1975-09-02 |
| HU170437B (en) | 1977-06-28 |
| FR2212136A1 (en) | 1974-07-26 |
| CA1009974A (en) | 1977-05-10 |
| ES421864A1 (en) | 1976-08-01 |
| DE2364883C2 (en) | 1984-07-19 |
| AU474971B2 (en) | 1976-08-05 |
| DD110490A5 (en) | 1974-12-20 |
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