IE38651L - Emulsion for parenteral administration - Google Patents
Emulsion for parenteral administrationInfo
- Publication number
- IE38651L IE38651L IE732289A IE228973A IE38651L IE 38651 L IE38651 L IE 38651L IE 732289 A IE732289 A IE 732289A IE 228973 A IE228973 A IE 228973A IE 38651 L IE38651 L IE 38651L
- Authority
- IE
- Ireland
- Prior art keywords
- acid
- parenteral administration
- adjuster
- emulsifier
- amino acids
- Prior art date
Links
- 238000007911 parenteral administration Methods 0.000 title abstract 2
- 239000000839 emulsion Substances 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000003797 essential amino acid Substances 0.000 abstract 3
- 235000020776 essential amino acid Nutrition 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 235000010469 Glycine max Nutrition 0.000 abstract 2
- 244000068988 Glycine max Species 0.000 abstract 2
- 239000003995 emulsifying agent Substances 0.000 abstract 2
- 235000015097 nutrients Nutrition 0.000 abstract 2
- 239000003002 pH adjusting agent Substances 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 235000009582 asparagine Nutrition 0.000 abstract 1
- 229960001230 asparagine Drugs 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 239000002385 cottonseed oil Substances 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000002960 lipid emulsion Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1397680 Nutrient composition SEPERIC 19 Dec 1973 [18 Jan 1973] 58819/73 Heading A5B A nutrient composition suitable for parenteral administration comprises an aqueous lipid emulsion of pH 7-8 containing (a) an emulsifier, (b) aminoacids in the aqueous phase including essential amino acids and arginine and (c) an acid pH adjuster. The lipid may be soyabean oil or cottonseed oil. The emulsifier may be egg or soyabean lecithin. The essential amino acids may be isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine. The pH adjuster may be aspartic acid, malic acid, tartaric acid or citric acid. The composition may also include non-essential aminoacids, e.g. histidine, proline, alanine, serine, asparagine, tyrosine, glycine, cysteine and a glucidic supply, e.g. sorbitol.
[GB1397680A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7301705A FR2215212B1 (en) | 1973-01-18 | 1973-01-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38651L true IE38651L (en) | 1974-07-18 |
| IE38651B1 IE38651B1 (en) | 1978-04-26 |
Family
ID=9113474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2289/73A IE38651B1 (en) | 1973-01-18 | 1973-12-18 | Improvements in or relating to an aqueous lipid emulsion for parenteral alimentation |
Country Status (12)
| Country | Link |
|---|---|
| AU (1) | AU476180B2 (en) |
| BE (1) | BE808823A (en) |
| CH (1) | CH574716A5 (en) |
| DE (1) | DE2303463C2 (en) |
| DK (1) | DK134097B (en) |
| ES (1) | ES422537A1 (en) |
| FR (1) | FR2215212B1 (en) |
| GB (1) | GB1397680A (en) |
| IE (1) | IE38651B1 (en) |
| NL (1) | NL7400673A (en) |
| SE (1) | SE422152B (en) |
| ZA (1) | ZA739667B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2530246A1 (en) * | 1975-07-07 | 1977-01-13 | Fresenius Chem Pharm Ind | L-AMINO ACID MIXTURES FOR PARENTERAL OR ORAL USE |
| DE2531204C2 (en) * | 1975-07-12 | 1987-01-22 | Fresenius AG, 6380 Bad Homburg | L-amino acid mixtures for parenteral or oral nutrition |
| DE2531201C2 (en) * | 1975-07-12 | 1986-05-28 | Fresenius AG, 6380 Bad Homburg | Amino acid infusion solutions for use in premature babies to young children |
| DE2642768A1 (en) * | 1976-09-23 | 1978-03-30 | Fresenius Chem Pharm Ind | MIXTURE CONTAINING ESSENTIAL AND NON-ESSENTIAL L-AMINO ACIDS FOR THE TREATMENT OF LIVER INSUFFICIENCY |
| FR2489145A1 (en) * | 1980-09-04 | 1982-03-05 | Geistlich Soehne Ag | PHARMACEUTICAL COMPOSITIONS ACCELERATING THE HEALING OF INJURIES |
| HU209973B (en) * | 1988-03-09 | 1995-01-30 | Biorex Kutato Fejlesztoe Kft | Process for production of antiviral and immunstimular pharmaceutical composition |
| GB9502131D0 (en) * | 1995-02-03 | 1995-03-22 | Mini Agriculture & Fisheries | Amino acid compositions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2662046A (en) * | 1948-06-19 | 1953-12-08 | Merck & Co Inc | Parenteral amino acid solution |
| US3080234A (en) * | 1960-12-06 | 1963-03-05 | Pfizer & Co C | Method of improving the efficiency of amino acid diets |
| AT297935B (en) * | 1968-05-09 | 1972-04-10 | Astra Ab | Process for the preparation of an infusion solution of essential amino acids for intravenous delivery in uremic conditions |
| DE1792294B1 (en) * | 1968-08-16 | 1970-07-09 | Braun Fa B | Process for the production of stable, non-pyrogenic, intravenous administrable, aqueous, amino acid-containing fat emulsions |
| DE1934317B1 (en) * | 1969-07-07 | 1970-10-15 | Braun Fa B | Process for the production of stable, non-pyrogenic, intravenous administrable, aqueous, amino acid-containing fat emulsions |
| ES392481A1 (en) * | 1970-06-29 | 1975-03-01 | Procter & Gamble | Stable oil- and water-soluble protein-containing product |
-
1973
- 1973-01-18 FR FR7301705A patent/FR2215212B1/fr not_active Expired
- 1973-01-25 DE DE2303463A patent/DE2303463C2/en not_active Expired
- 1973-12-17 CH CH1763573A patent/CH574716A5/xx not_active IP Right Cessation
- 1973-12-18 IE IE2289/73A patent/IE38651B1/en unknown
- 1973-12-19 BE BE139028A patent/BE808823A/en not_active IP Right Cessation
- 1973-12-19 GB GB5881973A patent/GB1397680A/en not_active Expired
- 1973-12-21 AU AU63920/73A patent/AU476180B2/en not_active Expired
- 1973-12-21 ZA ZA739667A patent/ZA739667B/en unknown
-
1974
- 1974-01-15 SE SE7400470A patent/SE422152B/en not_active IP Right Cessation
- 1974-01-16 DK DK22774AA patent/DK134097B/en not_active IP Right Cessation
- 1974-01-17 NL NL7400673A patent/NL7400673A/xx active Search and Examination
- 1974-01-17 ES ES422537A patent/ES422537A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2215212A1 (en) | 1974-08-23 |
| NL7400673A (en) | 1974-07-22 |
| DK134097B (en) | 1976-09-13 |
| ZA739667B (en) | 1974-11-27 |
| DE2303463C2 (en) | 1986-05-28 |
| FR2215212B1 (en) | 1976-03-05 |
| IE38651B1 (en) | 1978-04-26 |
| GB1397680A (en) | 1975-06-18 |
| DK134097C (en) | 1977-02-14 |
| AU6392073A (en) | 1975-06-26 |
| ES422537A1 (en) | 1976-05-01 |
| AU476180B2 (en) | 1976-09-16 |
| CH574716A5 (en) | 1976-04-30 |
| SE422152B (en) | 1982-02-22 |
| BE808823A (en) | 1974-04-16 |
| DE2303463A1 (en) | 1974-07-25 |
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