IE38736L - Aryloxy amines. - Google Patents
Aryloxy amines.Info
- Publication number
- IE38736L IE38736L IE740066A IE6674A IE38736L IE 38736 L IE38736 L IE 38736L IE 740066 A IE740066 A IE 740066A IE 6674 A IE6674 A IE 6674A IE 38736 L IE38736 L IE 38736L
- Authority
- IE
- Ireland
- Prior art keywords
- mes
- chohch
- alk
- condensates
- phenoxy
- Prior art date
Links
- -1 Aryloxy amines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical group O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- XDBOISFAMWQEOF-UHFFFAOYSA-N 2-[4-(3-bromopropoxy)phenoxy]oxane Chemical compound BrCCCOC1=CC=C(OC2OCCCC2)C=C1 XDBOISFAMWQEOF-UHFFFAOYSA-N 0.000 abstract 1
- LZBFDHGCFAXUHN-UHFFFAOYSA-N 5-[(4-hydroxyphenoxy)methyl]-3-propan-2-yl-1,3-oxazolidin-2-one Chemical compound OC1=CC=C(OCC2CN(C(O2)=O)C(C)C)C=C1 LZBFDHGCFAXUHN-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 abstract 1
- WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical group C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001800 adrenalinergic effect Effects 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 239000000021 stimulant Substances 0.000 abstract 1
- 150000003568 thioethers Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
Abstract
1423073 Amino group-containing thioethers and derivatives thereof CIBA-GEIGY AG 17 Jan 1974 [17 Jan 1973 26 Oct 1973] 02187/74 Heading C2C Novel compounds (I) (including salts thereof): where Alk 1 is alkyl, alk 2 is alkylene, Ph is optionally substituted p-phenylene and R is alkyl or aralkyl, as well as their condensates with aldehydes, ketones and carbonic acid (i.e. the -CHOH.CH 2 -NHR moiety is converted to an oxazolidine or oxazolidin-2-one group), are made by standard methods. The following compounds are also prepared: 5 - [(4 - hydroxy - phenoxy) - methyl] - 3 - isopropyl oxazolidin - 2 - one, MeS(CH 2 ) 2 O-Ph-O-CH 2 CHOHCH 2 NH 2 , MeS(CH 2 ) 2 or 3 -O-Ph-OH, MeS(CH 2 ) 2 or 3 -O-Ph-O-CH 2 -oxirane, MeS(CH 2 ) 2 -O-Ph-O-CH 2 CHOHCH 2 Cl, 2 - [4 - (3 - bromopropoxy) - phenoxy] - tetrahydropyran and 2 - (4 - benzyloxy and -hydroxyphenoxy)-tetrahydropyrans. Pharmaceutical preparations useful as cardioselective antagonists of adrenergic #-receptor stimulants, e.g. for treating arrhythmias and angina pectoris contain (I) and/or their condensates as active ingredient.
[GB1423073A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH62173A CH576438A5 (en) | 1973-01-17 | 1973-01-17 | 1-Alkylthioalkoxy-4-(3-amino-2-hydroxypropoxy) benzenes - antagonists of beta receptor stimulants prepd. e.g. by reducing corresp. Schiff base |
| CH1516473 | 1973-10-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38736L true IE38736L (en) | 1974-07-17 |
| IE38736B1 IE38736B1 (en) | 1978-05-24 |
Family
ID=25685144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE66/74A IE38736B1 (en) | 1973-01-17 | 1974-01-11 | Amines and processes for their manufacture |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS49101343A (en) |
| AR (6) | AR204105A1 (en) |
| AT (2) | AT330771B (en) |
| BE (1) | BE809820A (en) |
| CA (1) | CA1050032A (en) |
| CS (1) | CS184347B2 (en) |
| DD (2) | DD110656A5 (en) |
| DE (1) | DE2400693A1 (en) |
| ES (1) | ES422301A1 (en) |
| FR (1) | FR2213771B1 (en) |
| GB (1) | GB1423073A (en) |
| HU (1) | HU168750B (en) |
| IE (1) | IE38736B1 (en) |
| IL (1) | IL44003A (en) |
| LU (1) | LU69166A1 (en) |
| NL (1) | NL7400648A (en) |
| SU (1) | SU520037A3 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002004B1 (en) * | 1977-11-07 | 1982-03-24 | Ciba-Geigy Ag | Process for the manufacture of fluorinated cationic compounds and their use as surfactants |
| ZW9881A1 (en) * | 1980-06-02 | 1981-12-23 | Hoffmann La Roche | Substituted phenoxyaminopropanol derivatives |
| DE3125870C2 (en) * | 1980-07-09 | 1994-09-15 | William John Louis | 3-aminopropoxyphenyl derivatives, their preparation and medicaments containing them |
| JPS5746946A (en) * | 1980-07-09 | 1982-03-17 | Sandoz Ag | 3-aminopropoxyphenyl derivative, manufacture and medicine containing same |
| FR2497194B1 (en) * | 1980-08-07 | 1985-06-14 | Sandoz Sa | NEW PHENOLIC COMPOUNDS |
| US6068834A (en) | 1994-03-04 | 2000-05-30 | The Procter & Gamble Company | Skin lightening compositions |
| WO1995023778A2 (en) * | 1994-03-04 | 1995-09-08 | The Procter & Gamble Company | Process for making monoacetals of hydroquinone |
| US5585525A (en) * | 1994-12-16 | 1996-12-17 | The Procter & Gamble Company | Process for making monoacetals of hydroquinone |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA956632A (en) * | 1969-05-16 | 1974-10-22 | Yoshitomi Pharmaceutical Industries | Phenoxy-aminopropanol derivatives |
-
1974
- 1974-01-01 AR AR255900A patent/AR204105A1/en active
- 1974-01-01 AR AR255898A patent/AR204726A1/en active
- 1974-01-01 AR AR251941A patent/AR205618A1/en active
- 1974-01-01 AR AR255899A patent/AR204334A1/en active
- 1974-01-08 DE DE2400693A patent/DE2400693A1/en active Pending
- 1974-01-11 CS CS7700000292A patent/CS184347B2/en unknown
- 1974-01-11 IE IE66/74A patent/IE38736B1/en unknown
- 1974-01-14 SU SU1985268A patent/SU520037A3/en active
- 1974-01-14 FR FR7401149A patent/FR2213771B1/fr not_active Expired
- 1974-01-14 CA CA190,087A patent/CA1050032A/en not_active Expired
- 1974-01-14 IL IL44003A patent/IL44003A/en unknown
- 1974-01-15 LU LU69166A patent/LU69166A1/xx unknown
- 1974-01-15 DD DD176012A patent/DD110656A5/xx unknown
- 1974-01-15 ES ES422301A patent/ES422301A1/en not_active Expired
- 1974-01-15 DD DD180359A patent/DD113364A5/xx unknown
- 1974-01-16 BE BE139875A patent/BE809820A/en unknown
- 1974-01-16 HU HUCI1435A patent/HU168750B/hu unknown
- 1974-01-17 GB GB218774A patent/GB1423073A/en not_active Expired
- 1974-01-17 NL NL7400648A patent/NL7400648A/xx not_active Application Discontinuation
- 1974-01-17 JP JP49007590A patent/JPS49101343A/ja active Pending
- 1974-10-02 AR AR255896A patent/AR201704A1/en active
- 1974-10-02 AR AR255897A patent/AR201518A1/en active
-
1975
- 1975-05-26 AT AT397675A patent/AT330771B/en not_active IP Right Cessation
- 1975-05-26 AT AT397875A patent/AT330750B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA397875A (en) | 1975-10-15 |
| HU168750B (en) | 1976-07-28 |
| CA1050032A (en) | 1979-03-06 |
| AR204105A1 (en) | 1975-11-20 |
| JPS49101343A (en) | 1974-09-25 |
| AR204334A1 (en) | 1975-12-22 |
| DE2400693A1 (en) | 1974-07-18 |
| ATA397675A (en) | 1975-10-15 |
| SU520037A3 (en) | 1976-06-30 |
| DD113364A5 (en) | 1975-06-05 |
| LU69166A1 (en) | 1975-12-09 |
| IL44003A0 (en) | 1974-05-16 |
| DD110656A5 (en) | 1975-01-05 |
| AR204726A1 (en) | 1976-02-27 |
| FR2213771B1 (en) | 1976-09-03 |
| IL44003A (en) | 1977-05-31 |
| ES422301A1 (en) | 1976-07-01 |
| FR2213771A1 (en) | 1974-08-09 |
| AR201518A1 (en) | 1975-03-21 |
| AR201704A1 (en) | 1975-04-08 |
| GB1423073A (en) | 1976-01-28 |
| AT330750B (en) | 1976-07-12 |
| AR205618A1 (en) | 1976-05-21 |
| AU6452474A (en) | 1975-07-17 |
| IE38736B1 (en) | 1978-05-24 |
| BE809820A (en) | 1974-07-16 |
| AT330771B (en) | 1976-07-26 |
| CS184347B2 (en) | 1978-08-31 |
| NL7400648A (en) | 1974-07-19 |
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