IE38780L - Metabolite a-27106 - Google Patents
Metabolite a-27106Info
- Publication number
- IE38780L IE38780L IE740129A IE12974A IE38780L IE 38780 L IE38780 L IE 38780L IE 740129 A IE740129 A IE 740129A IE 12974 A IE12974 A IE 12974A IE 38780 L IE38780 L IE 38780L
- Authority
- IE
- Ireland
- Prior art keywords
- metabolite
- feed
- monensin
- carbon
- molecular weight
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Feed For Specific Animals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1457796 Metabolite A-27106 ELI LILLY & CO 30 Jan 1974 [1 Feb 1973] 04414/74 Headings C2A and C2C The invention relates to Metabolite A-27106 and the acid, ammonium, lithium, potassium, rubidium or cesium forms thereof. The metabolite is a white crystalline solid with (a) a molecular weight of 854, as determined by mass spectrometry; (b) an elemental composition of 58À78% carbon, 8À51% hydrogen, 27À85% oxygen and 3À63% sodium; (c) an empirical formula of C 42 H 71 O 16 Na; (d) an infra-red absorption spectrum in chloroform as shown in the accompanying drawing; (e) a mass spectrum having a molecular-ion peak at m./e. 854À44630 and characteristic peaks at m./e. 836À44129, 779À44690, 761À44740; and (f) an Rf value of 0À49 on silica gel thin layer chromatography in benzene-methanol (7 : 3); and the acid form is a white solid having a molecular weight of 832 and a titratable group with a pKa value of 7À2. The following structure is proposed for Metabolite A-27106. Metabolite A-27106 is prepared by cultivating Streptomyces candidus NRRL 5449 in a culture medium containing assimilable sources of carbon, nitrogen and inorganic salts under submerged aerobic conditions in the presence of glucose and monensin until monensin is converted into metabolite A-27106. The metabolite may be mixed with a physiologically-acceptable carrier, e.g. poultry feed, and administered to poultry for preventing or treating coccidiosis therein. The metabolite may also be mixed with ruminant feed for increasing the efficiency of feed utilization of ruminant animals.
[GB1457796A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32858673A | 1973-02-01 | 1973-02-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38780L true IE38780L (en) | 1974-08-01 |
| IE38780B1 IE38780B1 (en) | 1978-05-24 |
Family
ID=23281582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE129/74A IE38780B1 (en) | 1973-02-01 | 1974-01-22 | Metabolite a-27106 and process for its preparation and us |
Country Status (27)
| Country | Link |
|---|---|
| JP (2) | JPS5730477B2 (en) |
| AR (1) | AR206509A1 (en) |
| AT (1) | AT328083B (en) |
| BE (1) | BE810416A (en) |
| BG (1) | BG26953A3 (en) |
| CA (1) | CA1016483A (en) |
| CH (1) | CH589140A5 (en) |
| CS (1) | CS193481B2 (en) |
| DD (1) | DD112441A5 (en) |
| DE (1) | DE2404958C2 (en) |
| DK (1) | DK143036C (en) |
| EG (1) | EG11287A (en) |
| ES (1) | ES422834A1 (en) |
| FI (1) | FI52993C (en) |
| FR (1) | FR2215943B1 (en) |
| GB (1) | GB1457796A (en) |
| HU (1) | HU167276B (en) |
| IE (1) | IE38780B1 (en) |
| IL (1) | IL44065A (en) |
| IN (1) | IN139462B (en) |
| NL (1) | NL181367C (en) |
| NO (1) | NO139788C (en) |
| PH (1) | PH12449A (en) |
| SE (1) | SE401930B (en) |
| SU (1) | SU539538A3 (en) |
| YU (1) | YU36990B (en) |
| ZA (1) | ZA74464B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6384471U (en) * | 1986-11-21 | 1988-06-02 | ||
| JPH0483920U (en) * | 1990-11-30 | 1992-07-21 | ||
| JPH0512236U (en) * | 1991-07-26 | 1993-02-19 | 東京ラヂエーター製造株式会社 | Fuel tank backflow prevention structure |
-
1974
- 1974-01-01 AR AR252171A patent/AR206509A1/en active
- 1974-01-22 ZA ZA00740464A patent/ZA74464B/en unknown
- 1974-01-22 IE IE129/74A patent/IE38780B1/en unknown
- 1974-01-22 IL IL44065A patent/IL44065A/en unknown
- 1974-01-22 CA CA190,655A patent/CA1016483A/en not_active Expired
- 1974-01-24 PH PH15441A patent/PH12449A/en unknown
- 1974-01-25 YU YU0190/74A patent/YU36990B/en unknown
- 1974-01-29 IN IN191/CAL/74A patent/IN139462B/en unknown
- 1974-01-30 GB GB441474A patent/GB1457796A/en not_active Expired
- 1974-01-30 NL NLAANVRAGE7401311,A patent/NL181367C/en not_active IP Right Cessation
- 1974-01-30 NO NO740292A patent/NO139788C/en unknown
- 1974-01-31 ES ES422834A patent/ES422834A1/en not_active Expired
- 1974-01-31 BE BE1005684A patent/BE810416A/en not_active IP Right Cessation
- 1974-01-31 AT AT76874*#A patent/AT328083B/en not_active IP Right Cessation
- 1974-01-31 SE SE7401314A patent/SE401930B/en not_active IP Right Cessation
- 1974-01-31 HU HUEI523A patent/HU167276B/hu not_active IP Right Cessation
- 1974-01-31 DD DD176301A patent/DD112441A5/xx unknown
- 1974-01-31 DK DK51474A patent/DK143036C/en not_active IP Right Cessation
- 1974-02-01 SU SU2002131A patent/SU539538A3/en active
- 1974-02-01 CS CS74699A patent/CS193481B2/en unknown
- 1974-02-01 FR FR7403437A patent/FR2215943B1/fr not_active Expired
- 1974-02-01 FI FI283/74A patent/FI52993C/fi active
- 1974-02-01 CH CH143874A patent/CH589140A5/xx not_active IP Right Cessation
- 1974-02-01 DE DE2404958A patent/DE2404958C2/en not_active Expired
- 1974-02-01 JP JP1403874A patent/JPS5730477B2/ja not_active Expired
- 1974-02-01 BG BG025678A patent/BG26953A3/en unknown
- 1974-02-02 EG EG29/74A patent/EG11287A/en active
-
1981
- 1981-10-20 JP JP56168525A patent/JPS6026374B2/en not_active Expired
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