IE38886L - Quinoline-3-carboxamidotetrazole derivatives - Google Patents

Quinoline-3-carboxamidotetrazole derivatives

Info

Publication number
IE38886L
IE38886L IE740249A IE24974A IE38886L IE 38886 L IE38886 L IE 38886L IE 740249 A IE740249 A IE 740249A IE 24974 A IE24974 A IE 24974A IE 38886 L IE38886 L IE 38886L
Authority
IE
Ireland
Prior art keywords
alkyl group
hydrogen atom
group
compounds
hydroxy
Prior art date
Application number
IE740249A
Other versions
IE38886B1 (en
Original Assignee
Allen & Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen & Hanburys Ltd filed Critical Allen & Hanburys Ltd
Publication of IE38886L publication Critical patent/IE38886L/en
Publication of IE38886B1 publication Critical patent/IE38886B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

1433774 Tetrazole-derived amides ALLEN & HANBURYS 6 Feb 1974 [26 Feb 1973] 9249/73 Heading C2C The invention comprises compounds of formula their 4-oxyquinoline tautomers (when R 4 =H) and pharmaceutically acceptable salts and esters thereof, in which : R 1 and R 2 which may be the same or different represent a hydrogen atom, a halogen atom, or an alkyl, trifluoromethyl or nitro group, or a group OR 3 in which R 3 represents a hydrogen atom, or an alkenyl or alkyl group, which alkyl group may be substituted by alkoxy, aryl, amino, alkylamino, dialkylamino, hydroxy or acyloxy groups; or a group NR 6 R 7 in which R 6 and R 7 which may be the same or different represent a hydrogen atom or an alkyl group, which alkyl group may be substituted with a hydroxy or acyloxy group, or in which R 6 and R 7 together with the nitrogen atom form a 5- or 6-membered ring which may contain additional hetero atoms; R 4 represents a hydrogen atom, an alkenyl or alkyl group, which alkyl group may be substituted with hydroxy, acyloxy, alkoxy, aryl, amino, alkylamino, dialkylamino or alkylaralkylamino groups; and R 5 represents a hydrogen atom or an alkyl group. In examples, these compounds are prepared by reacting the corresponding quinolonecarboxylic acid (A) (or a functional derivative thereof such as the acid chloride or the mixed anhydride with EtOCO 2 H) with 5-aminotetrazole and by the interconversion of functional groups in compounds thus prepared; the acids (A) are made by hydrolysing the corresponding esters. Therapeutic compositions for treating conditions primarily caused by antigen/reaginic antibody combination comprise compounds of the above formula, and may be administered orally or by inhalation. [GB1433774A]
IE00249/74A 1973-02-26 1974-02-08 Heterocyclic compounds IE38886B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB924973A GB1433774A (en) 1973-02-26 1973-02-26 Heterocyclic compounds apparatus for conveying articles

Publications (2)

Publication Number Publication Date
IE38886L true IE38886L (en) 1974-08-26
IE38886B1 IE38886B1 (en) 1978-06-21

Family

ID=9868317

Family Applications (1)

Application Number Title Priority Date Filing Date
IE00249/74A IE38886B1 (en) 1973-02-26 1974-02-08 Heterocyclic compounds

Country Status (14)

Country Link
JP (1) JPS5029574A (en)
AT (1) AT329562B (en)
AU (1) AU474797B2 (en)
BE (1) BE811246A (en)
CA (1) CA1025856A (en)
CH (1) CH602707A5 (en)
DE (1) DE2407744A1 (en)
FR (1) FR2218896B1 (en)
GB (1) GB1433774A (en)
IE (1) IE38886B1 (en)
LU (1) LU69479A1 (en)
NL (1) NL7402613A (en)
SE (1) SE7401984L (en)
ZA (1) ZA74883B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2324304A2 (en) * 1975-09-22 1977-04-15 Roussel Uclaf Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine
US4186201A (en) 1977-02-07 1980-01-29 Riker Laboratories, Inc. Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds
US4264604A (en) 1977-07-01 1981-04-28 Ciba-Geigy Corporation Quinolonecarboxylic acid derivatives as bactericides
US4390541A (en) 1980-12-19 1983-06-28 Lilly Industries Limited Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease
FR2509728A1 (en) * 1981-07-17 1983-01-21 Roussel Uclaf NOVEL QUINOLINE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME
US4377579A (en) 1981-12-03 1983-03-22 Minnesota Mining And Manufacturing Company N-(Tetrazol-5-yl)phenazine-1-carboxamides
FR2537140B1 (en) * 1982-12-07 1986-07-18 Roussel Uclaf NOVEL 4-HYDROXY-3-QUINOLEINE CARBOXAMIDE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, AND COMPOSITIONS CONTAINING THEM
KR960004827B1 (en) * 1987-01-20 1996-04-16 다이닛뽄 세이야꾸 가부시끼가이샤 Heteroarylcarboxyamide derivatives, preparation method thereof and pharmaceutical composition containing the same
US4959363A (en) * 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
US6034100A (en) * 1993-03-10 2000-03-07 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting cytokine secretion
US6143760A (en) 1997-08-25 2000-11-07 Neurogen Corporation Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
PL338783A1 (en) * 1997-08-25 2000-11-20 Neurogen Corp Substituted 4-oxo-naphtyridin-3-carboxamides as ligands of cerebral gaba receptors
BR9908321A (en) 1998-02-26 2001-12-18 Neurogen Corp Compound
NZ536061A (en) * 2002-05-14 2008-09-26 Univ California Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
WO2005009971A1 (en) * 2003-07-24 2005-02-03 Astellas Pharma Inc. Quinolone derivative or salt thereof
RU2556984C2 (en) * 2004-06-24 2015-07-20 Вертекс Фармасьютикалз Инкорпорейтед Modulators of atp-binding cassette transporters
EP2502914A3 (en) * 2004-06-24 2013-12-04 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
RS56037B1 (en) 2004-06-24 2017-09-29 Vertex Pharma ATP-BINDING CASSETTE TRANSPORT MODULATORS
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
EP3219705B1 (en) 2005-12-28 2020-03-11 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
PL2408750T3 (en) 2009-03-20 2016-02-29 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
JP2015511583A (en) 2012-02-27 2015-04-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Pharmaceutical composition and its administration
JP6211509B2 (en) 2012-03-02 2017-10-11 武田薬品工業株式会社 Heterocyclic compounds and uses thereof
WO2014077401A1 (en) 2012-11-19 2014-05-22 武田薬品工業株式会社 Nitrogen-containing heterocyclic compound
CN107250113B (en) 2014-10-07 2019-03-29 弗特克斯药品有限公司 Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator proteins
CN105330602B (en) * 2015-12-07 2018-02-09 江南大学 A kind of deccox analog and its application

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1383088A (en) * 1972-07-03 1975-02-05 Allen & Hanburys Ltd Pharmacologically active quinaldamide derivatives

Also Published As

Publication number Publication date
JPS5029574A (en) 1975-03-25
CH602707A5 (en) 1978-07-31
LU69479A1 (en) 1975-05-21
SE7401984L (en) 1974-08-27
GB1433774A (en) 1976-04-28
AU474797B2 (en) 1976-08-05
BE811246A (en) 1974-08-19
FR2218896A1 (en) 1974-09-20
AT329562B (en) 1976-05-25
AU6559274A (en) 1975-08-14
NL7402613A (en) 1974-08-28
FR2218896B1 (en) 1977-09-09
DE2407744A1 (en) 1974-08-29
ATA149974A (en) 1975-08-15
ZA74883B (en) 1974-12-24
IE38886B1 (en) 1978-06-21
CA1025856A (en) 1978-02-07

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