IE38886L - Quinoline-3-carboxamidotetrazole derivatives - Google Patents
Quinoline-3-carboxamidotetrazole derivativesInfo
- Publication number
- IE38886L IE38886L IE740249A IE24974A IE38886L IE 38886 L IE38886 L IE 38886L IE 740249 A IE740249 A IE 740249A IE 24974 A IE24974 A IE 24974A IE 38886 L IE38886 L IE 38886L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl group
- hydrogen atom
- group
- compounds
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1433774 Tetrazole-derived amides ALLEN & HANBURYS 6 Feb 1974 [26 Feb 1973] 9249/73 Heading C2C The invention comprises compounds of formula their 4-oxyquinoline tautomers (when R 4 =H) and pharmaceutically acceptable salts and esters thereof, in which : R 1 and R 2 which may be the same or different represent a hydrogen atom, a halogen atom, or an alkyl, trifluoromethyl or nitro group, or a group OR 3 in which R 3 represents a hydrogen atom, or an alkenyl or alkyl group, which alkyl group may be substituted by alkoxy, aryl, amino, alkylamino, dialkylamino, hydroxy or acyloxy groups; or a group NR 6 R 7 in which R 6 and R 7 which may be the same or different represent a hydrogen atom or an alkyl group, which alkyl group may be substituted with a hydroxy or acyloxy group, or in which R 6 and R 7 together with the nitrogen atom form a 5- or 6-membered ring which may contain additional hetero atoms; R 4 represents a hydrogen atom, an alkenyl or alkyl group, which alkyl group may be substituted with hydroxy, acyloxy, alkoxy, aryl, amino, alkylamino, dialkylamino or alkylaralkylamino groups; and R 5 represents a hydrogen atom or an alkyl group. In examples, these compounds are prepared by reacting the corresponding quinolonecarboxylic acid (A) (or a functional derivative thereof such as the acid chloride or the mixed anhydride with EtOCO 2 H) with 5-aminotetrazole and by the interconversion of functional groups in compounds thus prepared; the acids (A) are made by hydrolysing the corresponding esters. Therapeutic compositions for treating conditions primarily caused by antigen/reaginic antibody combination comprise compounds of the above formula, and may be administered orally or by inhalation.
[GB1433774A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB924973A GB1433774A (en) | 1973-02-26 | 1973-02-26 | Heterocyclic compounds apparatus for conveying articles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38886L true IE38886L (en) | 1974-08-26 |
| IE38886B1 IE38886B1 (en) | 1978-06-21 |
Family
ID=9868317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE00249/74A IE38886B1 (en) | 1973-02-26 | 1974-02-08 | Heterocyclic compounds |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5029574A (en) |
| AT (1) | AT329562B (en) |
| AU (1) | AU474797B2 (en) |
| BE (1) | BE811246A (en) |
| CA (1) | CA1025856A (en) |
| CH (1) | CH602707A5 (en) |
| DE (1) | DE2407744A1 (en) |
| FR (1) | FR2218896B1 (en) |
| GB (1) | GB1433774A (en) |
| IE (1) | IE38886B1 (en) |
| LU (1) | LU69479A1 (en) |
| NL (1) | NL7402613A (en) |
| SE (1) | SE7401984L (en) |
| ZA (1) | ZA74883B (en) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2324304A2 (en) * | 1975-09-22 | 1977-04-15 | Roussel Uclaf | Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine |
| US4186201A (en) | 1977-02-07 | 1980-01-29 | Riker Laboratories, Inc. | Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds |
| US4264604A (en) | 1977-07-01 | 1981-04-28 | Ciba-Geigy Corporation | Quinolonecarboxylic acid derivatives as bactericides |
| US4390541A (en) | 1980-12-19 | 1983-06-28 | Lilly Industries Limited | Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease |
| FR2509728A1 (en) * | 1981-07-17 | 1983-01-21 | Roussel Uclaf | NOVEL QUINOLINE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME |
| US4377579A (en) | 1981-12-03 | 1983-03-22 | Minnesota Mining And Manufacturing Company | N-(Tetrazol-5-yl)phenazine-1-carboxamides |
| FR2537140B1 (en) * | 1982-12-07 | 1986-07-18 | Roussel Uclaf | NOVEL 4-HYDROXY-3-QUINOLEINE CARBOXAMIDE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, AND COMPOSITIONS CONTAINING THEM |
| KR960004827B1 (en) * | 1987-01-20 | 1996-04-16 | 다이닛뽄 세이야꾸 가부시끼가이샤 | Heteroarylcarboxyamide derivatives, preparation method thereof and pharmaceutical composition containing the same |
| US4959363A (en) * | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
| US6034100A (en) * | 1993-03-10 | 2000-03-07 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting cytokine secretion |
| HUP0003258A3 (en) * | 1997-08-25 | 2001-05-28 | Neurogen Corp Branford | Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands |
| US6143760A (en) * | 1997-08-25 | 2000-11-07 | Neurogen Corporation | Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands |
| AU2794099A (en) | 1998-02-26 | 1999-09-15 | Neurogen Corporation | Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands |
| EP1503759B1 (en) * | 2002-05-14 | 2008-12-17 | The Regents Of The University Of California | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof |
| WO2005009971A1 (en) | 2003-07-24 | 2005-02-03 | Astellas Pharma Inc. | Quinolone derivative or salt thereof |
| CA2881078C (en) * | 2004-06-24 | 2018-10-02 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| RU2525115C2 (en) * | 2004-06-24 | 2014-08-10 | Вертекс Фармасьютикалз Инкорпорейтед | Method of modulating transporters of atp-binding cassette |
| EP2502912A3 (en) * | 2004-06-24 | 2013-11-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| LT1993360T (en) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| SI3330255T1 (en) | 2009-03-20 | 2021-03-31 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| EP2819670B1 (en) | 2012-02-27 | 2026-05-20 | Vertex Pharmaceuticals Incorporated | Pharmaceutical preparations and their administration |
| US9403802B2 (en) | 2012-03-02 | 2016-08-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use therefor |
| WO2014077401A1 (en) | 2012-11-19 | 2014-05-22 | 武田薬品工業株式会社 | Nitrogen-containing heterocyclic compound |
| CA2963945C (en) | 2014-10-07 | 2023-01-10 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| CN105330602B (en) * | 2015-12-07 | 2018-02-09 | 江南大学 | A kind of deccox analog and its application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1383088A (en) * | 1972-07-03 | 1975-02-05 | Allen & Hanburys Ltd | Pharmacologically active quinaldamide derivatives |
-
1973
- 1973-02-26 GB GB924973A patent/GB1433774A/en not_active Expired
-
1974
- 1974-02-08 IE IE00249/74A patent/IE38886B1/en unknown
- 1974-02-11 ZA ZA740883A patent/ZA74883B/en unknown
- 1974-02-14 AU AU65592/74A patent/AU474797B2/en not_active Expired
- 1974-02-14 SE SE7401984A patent/SE7401984L/xx unknown
- 1974-02-18 CH CH224374A patent/CH602707A5/xx not_active IP Right Cessation
- 1974-02-18 DE DE19742407744 patent/DE2407744A1/en active Pending
- 1974-02-19 BE BE141102A patent/BE811246A/en unknown
- 1974-02-22 LU LU69479A patent/LU69479A1/xx unknown
- 1974-02-25 AT AT149974A patent/AT329562B/en not_active IP Right Cessation
- 1974-02-25 FR FR7406327A patent/FR2218896B1/fr not_active Expired
- 1974-02-25 JP JP49022232A patent/JPS5029574A/ja active Pending
- 1974-02-26 CA CA193,476A patent/CA1025856A/en not_active Expired
- 1974-02-26 NL NL7402613A patent/NL7402613A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NL7402613A (en) | 1974-08-28 |
| FR2218896A1 (en) | 1974-09-20 |
| ATA149974A (en) | 1975-08-15 |
| JPS5029574A (en) | 1975-03-25 |
| ZA74883B (en) | 1974-12-24 |
| FR2218896B1 (en) | 1977-09-09 |
| DE2407744A1 (en) | 1974-08-29 |
| LU69479A1 (en) | 1975-05-21 |
| CA1025856A (en) | 1978-02-07 |
| IE38886B1 (en) | 1978-06-21 |
| AU474797B2 (en) | 1976-08-05 |
| AT329562B (en) | 1976-05-25 |
| CH602707A5 (en) | 1978-07-31 |
| GB1433774A (en) | 1976-04-28 |
| AU6559274A (en) | 1975-08-14 |
| BE811246A (en) | 1974-08-19 |
| SE7401984L (en) | 1974-08-27 |
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