IE38917L - Isoquinoline derivatives. - Google Patents
Isoquinoline derivatives.Info
- Publication number
- IE38917L IE38917L IE740358A IE35874A IE38917L IE 38917 L IE38917 L IE 38917L IE 740358 A IE740358 A IE 740358A IE 35874 A IE35874 A IE 35874A IE 38917 L IE38917 L IE 38917L
- Authority
- IE
- Ireland
- Prior art keywords
- feb
- therapeutic compositions
- division
- agents
- ring
- Prior art date
Links
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 208000001953 Hypotension Diseases 0.000 abstract 1
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 abstract 1
- IFFPICMESYHZPQ-UHFFFAOYSA-N Prenylamine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCNC(C)CC1=CC=CC=C1 IFFPICMESYHZPQ-UHFFFAOYSA-N 0.000 abstract 1
- KXEMQEGRZWUKJS-UHFFFAOYSA-N Raufloridine Natural products COC1=CC=C2C(CCN3CC4C(C)OC=C(C4CC33)C(=O)OC)=C3NC2=C1 KXEMQEGRZWUKJS-UHFFFAOYSA-N 0.000 abstract 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 abstract 1
- JLRGJRBPOGGCBT-UHFFFAOYSA-N Tolbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 JLRGJRBPOGGCBT-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- CJCSPKMFHVPWAR-JTQLQIEISA-N alpha-methyl-L-dopa Chemical compound OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 CJCSPKMFHVPWAR-JTQLQIEISA-N 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 229960004111 buformin Drugs 0.000 abstract 1
- XSEUMFJMFFMCIU-UHFFFAOYSA-N buformin Chemical compound CCCC\N=C(/N)N=C(N)N XSEUMFJMFFMCIU-UHFFFAOYSA-N 0.000 abstract 1
- 229960005003 carbocromen Drugs 0.000 abstract 1
- KLOIYEQEVSIOOO-UHFFFAOYSA-N carbocromen Chemical compound CC1=C(CCN(CC)CC)C(=O)OC2=CC(OCC(=O)OCC)=CC=C21 KLOIYEQEVSIOOO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 abstract 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 abstract 1
- 229960004782 chlordiazepoxide Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 229960004580 glibenclamide Drugs 0.000 abstract 1
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 abstract 1
- QFWPJPIVLCBXFJ-UHFFFAOYSA-N glymidine Chemical compound N1=CC(OCCOC)=CN=C1NS(=O)(=O)C1=CC=CC=C1 QFWPJPIVLCBXFJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 229960004815 meprobamate Drugs 0.000 abstract 1
- 229960003105 metformin Drugs 0.000 abstract 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229960003243 phenformin Drugs 0.000 abstract 1
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 abstract 1
- 229960001989 prenylamine Drugs 0.000 abstract 1
- QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 abstract 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 229960005371 tolbutamide Drugs 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
1457186 Therapeutic compositions HOECHST AG 22 Feb 1974 [24 Feb 1973] 8171/74 Heading A5B [Also in Division C2] Therapeutic compositions having hypolipaemic and (in some cases) hypoglycaemic activity and which are preferably administered orally, comprise (with certain exclusions: see Division C2) compounds of formula wherein X is O or S; R<SP>1</SP> is H, C 1-6 alkyl or Ph; R<SP>2</SP> is H, or R<SP>1</SP>-R<SP>2</SP> forms with the ring 4-C atom a carbocyclic 5- or 6-membered ring; R<SP>3</SP>, R<SP>4</SP>, R<SP>5</SP> are each H, halogen or NO 2 ; and R<SP>6</SP>, R<SP>7</SP> are each H or C 1-4 alkoxy. Other pharmaceutically active substances which may be present are antidiabetics such as glycodiazin, tolbutamide, glibenclamide, phenformin, buformin and metformin; circulatory agents such as chromonar and prenylamine; hypotensives such as reserpin, alpha-methyldopa and clonidines; other hypolipaemics; geriatric agents; psycho-pharmaceuticals such as chlordiazepoxide, diazepan or meprobamate; and vitamins.
[GB1457186A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732309367 DE2309367A1 (en) | 1973-02-24 | 1973-02-24 | 1,4-DIHYDRO-4-H-ISOCHINOLINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38917L true IE38917L (en) | 1974-08-24 |
| IE38917B1 IE38917B1 (en) | 1978-06-21 |
Family
ID=5873034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE00358/74A IE38917B1 (en) | 1973-02-24 | 1974-02-22 | Isoquinoline derivatives and process for their manufactur |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS49117475A (en) |
| AT (1) | ATA146874A (en) |
| AU (1) | AU6593074A (en) |
| BE (1) | BE811528A (en) |
| CA (1) | CA1016173A (en) |
| DD (1) | DD114408A5 (en) |
| DE (1) | DE2309367A1 (en) |
| FR (1) | FR2218892B1 (en) |
| GB (1) | GB1457186A (en) |
| IE (1) | IE38917B1 (en) |
| IL (1) | IL44208A0 (en) |
| NL (1) | NL7402259A (en) |
| ZA (1) | ZA741172B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8328052D0 (en) * | 1983-10-20 | 1983-11-23 | Beecham Group Plc | Compounds |
| CN111039867A (en) * | 2019-12-11 | 2020-04-21 | 四川大学 | Green synthesis method of 3, 4-disubstituted isoquinoline derivative promoted by room-temperature illumination |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1354246A (en) * | 1971-05-27 | 1974-06-05 | Egyt Gyogyszervegyeszeti Gyar | 1,4-dihydro-3-2h-isoquinoline derivatives and a process for the preparation thereof |
-
1973
- 1973-02-24 DE DE19732309367 patent/DE2309367A1/en active Pending
-
1974
- 1974-02-14 IL IL44208A patent/IL44208A0/en unknown
- 1974-02-18 CA CA192,842A patent/CA1016173A/en not_active Expired
- 1974-02-19 NL NL7402259A patent/NL7402259A/xx unknown
- 1974-02-20 DD DD176704A patent/DD114408A5/xx unknown
- 1974-02-22 FR FR7406209A patent/FR2218892B1/fr not_active Expired
- 1974-02-22 ZA ZA00741172A patent/ZA741172B/en unknown
- 1974-02-22 AT AT146874A patent/ATA146874A/en not_active Application Discontinuation
- 1974-02-22 GB GB817174A patent/GB1457186A/en not_active Expired
- 1974-02-22 IE IE00358/74A patent/IE38917B1/en unknown
- 1974-02-23 JP JP49021064A patent/JPS49117475A/ja active Pending
- 1974-02-25 BE BE141348A patent/BE811528A/en unknown
- 1974-02-25 AU AU65930/74A patent/AU6593074A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2309367A1 (en) | 1974-09-05 |
| FR2218892A1 (en) | 1974-09-20 |
| CA1016173A (en) | 1977-08-23 |
| NL7402259A (en) | 1974-08-27 |
| AU6593074A (en) | 1975-08-28 |
| DD114408A5 (en) | 1975-08-05 |
| IE38917B1 (en) | 1978-06-21 |
| IL44208A0 (en) | 1974-05-16 |
| BE811528A (en) | 1974-08-26 |
| FR2218892B1 (en) | 1978-01-06 |
| ATA146874A (en) | 1977-08-15 |
| GB1457186A (en) | 1976-12-01 |
| JPS49117475A (en) | 1974-11-09 |
| ZA741172B (en) | 1975-01-29 |
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