IE38951L - Oral compositions containing biguanide derivatives - Google Patents
Oral compositions containing biguanide derivativesInfo
- Publication number
- IE38951L IE38951L IE740443A IE44374A IE38951L IE 38951 L IE38951 L IE 38951L IE 740443 A IE740443 A IE 740443A IE 44374 A IE44374 A IE 44374A IE 38951 L IE38951 L IE 38951L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- compositions
- oral compositions
- alanine
- march
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 150000004283 biguanides Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 abstract 1
- 239000000551 dentifrice Substances 0.000 abstract 1
- -1 fluoride ions Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000004957 naphthylene group Chemical group 0.000 abstract 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 230000007505 plaque formation Effects 0.000 abstract 1
- 239000000606 toothpaste Substances 0.000 abstract 1
- 229940034610 toothpaste Drugs 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
1449302 Oral compositions PROCTER & GAMBLE CO 6 March 1974 [6 March 1973] 10050/74 Heading A5B Oral compositions for inhibiting the formation of plaque, caries and calculus are obtained by bringing together (A) from 0.1 to 2.5% by weight of a bisguamide compound of formula: wherein A and A' are each (a) phenyl optionally substituted by up to two C1-C4 alkyl or alkoxy groups, nitro or halogen, (b) C1-C12 alkyl or (c) a C4-C12 alicyclic group; X and X' are' C1-C3 alkylene: z and z' are 0 or 1: R and R' are H, C1-C12 alkyl or C7-C@@ aralkyl; n is 2 to 12 and wherein the -(CH2)nchain may be interrupted by up to 5 -O-, -S-, phenylene or naphthylene moieties: or a pharmaceutically acceptable salt thereof: or a mixture of such compounds and/or salts, and (B) from 0.05 to 1.25% by weight in excess of the amount which will react with component (A) of nitrilo-triacetic acid, hendic acid, glycine, alpha-alanine, #-alanine, serine, leucine or valine. their water-soluble pharmaceutically acceptable salts or mixtures thereof. The compositions may also contain a water-soluble source of fluoride ions, and may be put up as dentifrices, such as toothpaste. The compositions eliminate or reduce the brown stain often found on oral surfaces when bis-guamide compounds are used therein.
[GB1449302A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33846373A | 1973-03-06 | 1973-03-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38951L true IE38951L (en) | 1974-09-06 |
| IE38951B1 IE38951B1 (en) | 1978-07-05 |
Family
ID=23324918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE00443/74A IE38951B1 (en) | 1973-03-06 | 1974-03-04 | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5029758A (en) |
| AT (1) | AT341103B (en) |
| BE (1) | BE811878A (en) |
| CA (1) | CA1028623A (en) |
| CH (1) | CH595101A5 (en) |
| DE (1) | DE2410132A1 (en) |
| DK (1) | DK138579B (en) |
| ES (1) | ES423959A1 (en) |
| FR (1) | FR2220263B1 (en) |
| GB (1) | GB1449302A (en) |
| IE (1) | IE38951B1 (en) |
| NL (1) | NL7402933A (en) |
| PH (1) | PH10396A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8342975A (en) * | 1974-08-09 | 1977-02-03 | Procter & Gamble | Oral compositions for plaque, caries and calculus retardationwith reduced staining tendencies |
| US4961923A (en) * | 1988-02-19 | 1990-10-09 | Dentsply Management Corp. | Irrigants for use in scaling and/or lavage apparatus |
| US6190642B1 (en) | 1988-02-19 | 2001-02-20 | Dentsply Research & Development Corp. | Irrigating and lavage compositions |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE374658B (en) * | 1972-07-31 | 1975-03-17 | Hesselgren S G |
-
1974
- 1974-03-02 DE DE2410132A patent/DE2410132A1/en active Pending
- 1974-03-04 IE IE00443/74A patent/IE38951B1/en unknown
- 1974-03-05 CA CA194,084A patent/CA1028623A/en not_active Expired
- 1974-03-05 NL NL7402933A patent/NL7402933A/xx not_active Application Discontinuation
- 1974-03-05 FR FR7407499A patent/FR2220263B1/fr not_active Expired
- 1974-03-05 PH PH15577A patent/PH10396A/en unknown
- 1974-03-05 BE BE141646A patent/BE811878A/en unknown
- 1974-03-05 AT AT179974A patent/AT341103B/en not_active IP Right Cessation
- 1974-03-05 CH CH304974A patent/CH595101A5/xx not_active IP Right Cessation
- 1974-03-06 JP JP49026101A patent/JPS5029758A/ja active Pending
- 1974-03-06 GB GB1005074A patent/GB1449302A/en not_active Expired
- 1974-03-06 DK DK121474AA patent/DK138579B/en unknown
- 1974-03-06 ES ES423959A patent/ES423959A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATA179974A (en) | 1977-05-15 |
| ES423959A1 (en) | 1976-05-16 |
| AU6634974A (en) | 1975-09-11 |
| GB1449302A (en) | 1976-09-15 |
| IE38951B1 (en) | 1978-07-05 |
| NL7402933A (en) | 1974-09-10 |
| DK138579C (en) | 1979-03-12 |
| FR2220263A1 (en) | 1974-10-04 |
| FR2220263B1 (en) | 1977-11-04 |
| AT341103B (en) | 1978-01-25 |
| BE811878A (en) | 1974-09-05 |
| JPS5029758A (en) | 1975-03-25 |
| PH10396A (en) | 1977-03-04 |
| DK138579B (en) | 1978-10-02 |
| CH595101A5 (en) | 1978-01-31 |
| CA1028623A (en) | 1978-03-28 |
| DE2410132A1 (en) | 1974-09-12 |
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