IE40218L - Process for recovering phenylalkylamines - Google Patents
Process for recovering phenylalkylaminesInfo
- Publication number
- IE40218L IE40218L IE742419A IE241974A IE40218L IE 40218 L IE40218 L IE 40218L IE 742419 A IE742419 A IE 742419A IE 241974 A IE241974 A IE 241974A IE 40218 L IE40218 L IE 40218L
- Authority
- IE
- Ireland
- Prior art keywords
- radical
- formula
- phenylalkylamine
- phenylalkylamines
- nov
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 3
- 230000003287 optical effect Effects 0.000 abstract 3
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- QCCDLTOVEPVEJK-UHFFFAOYSA-N phenylacetone Chemical compound CC(=O)CC1=CC=CC=C1 QCCDLTOVEPVEJK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1470110 Racemizing phenylalkylamines SYNTHELABO 29 Nov 1974 [29 Nov 1973 31 Oct 1974] 51828/74 Addition to 1415471 Heading C2C A racemic mixture of optical isomers of a phenylalkylamine derivative of the Formula (I) wherein Z is a H, Cl, CF 3 CF 3 O or CF 3 S radical, and each of R 1 and R 2 , which may be the same or different, is H or a straight or branched C 1-5 alkyl radical, a C 3-6 cycloalkyl radical or a phenylalkyl radical optionally substituted by a chlorine atom, or R 1 and R 2 , together with the nitrogen atom, form a heterocyclic radical, or an acid addition salt thereof, is obtained by oxidizing an optical isomer of a phenylalkylamine derivative (I) with N-chlorosuccinimide to give a 1-phenyl-2-propanone of Formula (II) which is then condensed with an amine of the formula HNK 1 R 2 to give a racemic mixture of optical isomers of the phenylalkylamine (I). The mixture so produced can then be resolved using known techniques. The process can be repeated as often as necessary to increase the yield of a desired isomer.
[GB1470110A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7342537A FR2253014A1 (en) | 1973-11-29 | 1973-11-29 | Racemising 1-phenyl-2-aminopropanes - by oxidising to ketone with N-chloro succinimide then reaction with amine |
| FR7436361A FR2289487A2 (en) | 1974-10-31 | 1974-10-31 | Racemising 1-phenyl-2-aminopropanes - by oxidising to ketone with N-chloro succinimide then reaction with amine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40218L true IE40218L (en) | 1975-05-29 |
| IE40218B1 IE40218B1 (en) | 1979-04-11 |
Family
ID=26218050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2419/14A IE40218B1 (en) | 1973-11-29 | 1974-11-26 | Process for recovering phenylalkylamines |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5331136B2 (en) |
| AT (1) | AT335421B (en) |
| CA (1) | CA1038406A (en) |
| CH (1) | CH603544A5 (en) |
| DK (1) | DK616474A (en) |
| GB (1) | GB1470110A (en) |
| IE (1) | IE40218B1 (en) |
| LU (1) | LU71383A1 (en) |
| NL (1) | NL7415466A (en) |
| NO (1) | NO744291L (en) |
| SE (1) | SE7414938L (en) |
-
1974
- 1974-11-26 IE IE2419/14A patent/IE40218B1/en unknown
- 1974-11-27 NL NL7415466A patent/NL7415466A/en not_active Application Discontinuation
- 1974-11-27 DK DK616474A patent/DK616474A/da unknown
- 1974-11-28 AT AT952574A patent/AT335421B/en not_active IP Right Cessation
- 1974-11-28 LU LU71383A patent/LU71383A1/xx unknown
- 1974-11-28 SE SE7414938A patent/SE7414938L/xx unknown
- 1974-11-28 NO NO744291A patent/NO744291L/no unknown
- 1974-11-28 CA CA214,853A patent/CA1038406A/en not_active Expired
- 1974-11-29 JP JP13761874A patent/JPS5331136B2/ja not_active Expired
- 1974-11-29 CH CH1588674A patent/CH603544A5/xx not_active IP Right Cessation
- 1974-11-29 GB GB5182874A patent/GB1470110A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5331136B2 (en) | 1978-08-31 |
| NO744291L (en) | 1975-06-23 |
| AU7579574A (en) | 1976-05-27 |
| JPS5088036A (en) | 1975-07-15 |
| NL7415466A (en) | 1975-06-02 |
| AT335421B (en) | 1977-03-10 |
| DK616474A (en) | 1975-07-28 |
| LU71383A1 (en) | 1975-08-20 |
| GB1470110A (en) | 1977-04-14 |
| IE40218B1 (en) | 1979-04-11 |
| SE7414938L (en) | 1975-05-30 |
| CH603544A5 (en) | 1978-08-31 |
| ATA952574A (en) | 1976-07-15 |
| CA1038406A (en) | 1978-09-12 |
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