IE40370L - Process for preparing injectable compositions. - Google Patents
Process for preparing injectable compositions.Info
- Publication number
- IE40370L IE40370L IE750158A IE15875A IE40370L IE 40370 L IE40370 L IE 40370L IE 750158 A IE750158 A IE 750158A IE 15875 A IE15875 A IE 15875A IE 40370 L IE40370 L IE 40370L
- Authority
- IE
- Ireland
- Prior art keywords
- allergen
- dialdehyde
- extract
- tyrosine
- aqueous solution
- Prior art date
Links
- 239000007972 injectable composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000013566 allergen Substances 0.000 abstract 5
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 abstract 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 230000002009 allergenic effect Effects 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 239000000284 extract Substances 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 239000000428 dust Substances 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 241000238740 Dermatophagoides pteronyssinus Species 0.000 abstract 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- 240000004658 Medicago sativa Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000000586 desensitisation Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000009342 ragweed pollen Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000008223 sterile water Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
1492973 Modified allergens BEECHAM GROUP Ltd 5 Feb 1975 [16 Feb 1974] 7156/74 Addition to 1377074 Heading A5B Finely divided micro-particles of tyrosine having a water soluble dialdehyde - treated allergen dispersed therein are prepared by mixing an aqueous solution of a water - soluble dialdehyde e.g. glutaraldehyde modified allergenic extract of an allergenic material with a solution of tyrosine in a strong aqueous acid e.g. hydrochloric acid; and simultaneously or subsequently neutralising (i.e. adjusting the pH to from 4 to 7.5) such mixture of solutions thereby precipitating the required product. Sodium hydroxide may be employed to neutralise the reaction mixture. The aqueous solution of modified allergen may be obtained directly by reacting an aqueous solution of an extract of allergenic material with a dialdehyde under neutral conditions. The allergen may be an extract of one or more pollens e.g. grass or ragweed pollen; house dust, the house dust mite Dermatophagoides pteronyssinus, moulds, animal hair, dander or fur. The precipitate of tyrosine containing the dialdehyde treated allergen may be removed from the solution by centrifugation or filtration and washed before being resuspended in a physiologically acceptable carrier such as phenol-saline or sterile water, to produce an injectable composition for use in desensitisation therapy.
[GB1492973A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7156/74A GB1492973A (en) | 1974-02-16 | 1974-02-16 | Process for preparing injectable compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40370L true IE40370L (en) | 1975-08-16 |
| IE40370B1 IE40370B1 (en) | 1979-05-09 |
Family
ID=9827690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE158/75A IE40370B1 (en) | 1974-02-16 | 1975-01-27 | Process for preparing injectable compositions |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5822444B2 (en) |
| BE (1) | BE825579R (en) |
| DE (1) | DE2505814C2 (en) |
| FR (1) | FR2261013B2 (en) |
| GB (1) | GB1492973A (en) |
| IE (1) | IE40370B1 (en) |
| KE (1) | KE3113A (en) |
| NL (1) | NL186295C (en) |
| ZA (1) | ZA75634B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4234569A (en) * | 1978-10-04 | 1980-11-18 | The Johns Hopkins University | Production of aldehyde-treated allergen-containing substances |
| US5057317A (en) * | 1987-03-24 | 1991-10-15 | Chugai Seiyaku Kabushiki Kaisha | Slow-release pharmaceutical agent |
| GB9706957D0 (en) * | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
| CZ302352B6 (en) | 1997-10-30 | 2011-03-30 | C. B. F. Leti, S. A. | Process for preparing extracts providing tolerance against allergenic material and their use |
| GB9820525D0 (en) | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
| GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3541201A (en) * | 1968-12-18 | 1970-11-17 | Ethan Alan Brown | Novel sodium chloride encapsulated injectionable substances |
| BE754523A (en) * | 1969-08-06 | 1971-02-08 | Beecham Group Ltd | VACCINES |
| GB1377074A (en) * | 1971-07-13 | 1974-12-11 | Beecham Group Ltd | Process for preparing injectable compositions |
-
1974
- 1974-02-16 GB GB7156/74A patent/GB1492973A/en not_active Expired
-
1975
- 1975-01-27 IE IE158/75A patent/IE40370B1/en unknown
- 1975-01-30 ZA ZA00750634A patent/ZA75634B/en unknown
- 1975-02-07 FR FR7503870A patent/FR2261013B2/fr not_active Expired
- 1975-02-11 NL NLAANVRAGE7501582,A patent/NL186295C/en not_active IP Right Cessation
- 1975-02-12 DE DE2505814A patent/DE2505814C2/en not_active Expired
- 1975-02-14 BE BE153404A patent/BE825579R/en active
- 1975-02-14 JP JP50018110A patent/JPS5822444B2/en not_active Expired
-
1981
- 1981-01-21 KE KE3113A patent/KE3113A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL186295C (en) | 1990-11-01 |
| BE825579R (en) | 1975-08-14 |
| DE2505814A1 (en) | 1975-09-18 |
| FR2261013A2 (en) | 1975-09-12 |
| AU7794375A (en) | 1976-08-05 |
| DE2505814C2 (en) | 1984-11-15 |
| KE3113A (en) | 1981-02-20 |
| ZA75634B (en) | 1976-01-28 |
| JPS5822444B2 (en) | 1983-05-09 |
| GB1492973A (en) | 1977-11-23 |
| NL7501582A (en) | 1975-08-19 |
| IE40370B1 (en) | 1979-05-09 |
| NL186295B (en) | 1990-06-01 |
| JPS50116626A (en) | 1975-09-12 |
| FR2261013B2 (en) | 1978-07-21 |
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