IE40517L - 3 - heterocyclic thiomethyl cephalosporins - Google Patents

3 - heterocyclic thiomethyl cephalosporins

Info

Publication number
IE40517L
IE40517L IE741859A IE185974A IE40517L IE 40517 L IE40517 L IE 40517L IE 741859 A IE741859 A IE 741859A IE 185974 A IE185974 A IE 185974A IE 40517 L IE40517 L IE 40517L
Authority
IE
Ireland
Prior art keywords
heterocyclic
thiadiazolyl
gram
valuable
heterocyclic thiomethyl
Prior art date
Application number
IE741859A
Other languages
Unknown language ( )
Other versions
IE40517B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE40517L publication Critical patent/IE40517L/en
Publication of IE40517B1 publication Critical patent/IE40517B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C337/00—Derivatives of thiocarbonic acids containing functional groups covered by groups C07C333/00 or C07C335/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C337/06—Compounds containing any of the groups, e.g. thiosemicarbazides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

7-(2-Aminomethylphenylacetamido-3-(heterocyclic-substituted)thiomethyl -3-cephem-4-carboxylic acids in which the heterocyclic substituent is 2-(1,3,4-thiadiazolyl)- or 2-(5-hydroxymethyl-1,3,4-thiadiazolyl)-, and their nontoxic, pharmaceutically acceptable salts and their Schiff bases, as made by reaction of salicylaldehyde with the free amino group, are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria.
IE1859/74A 1973-09-07 1974-09-06 7-(substituted phenyl-acetamido)-3-heterocyclic thiomethyl-3cephem-4-carboxylic acids IE40517B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US395102A US3910899A (en) 1973-09-07 1973-09-07 7-(2-Aminomethylphenyl-acetamido)-3-{8 2-(5-hydroxymethyl-1,3,4-thiadiazolyl)-thiomethyl{9 -3-cephem-4-carboxylic acid

Publications (2)

Publication Number Publication Date
IE40517L true IE40517L (en) 1975-03-07
IE40517B1 IE40517B1 (en) 1979-06-20

Family

ID=23561697

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1859/74A IE40517B1 (en) 1973-09-07 1974-09-06 7-(substituted phenyl-acetamido)-3-heterocyclic thiomethyl-3cephem-4-carboxylic acids

Country Status (16)

Country Link
US (1) US3910899A (en)
JP (1) JPS5062991A (en)
BE (1) BE819541A (en)
CA (1) CA1031325A (en)
CH (1) CH611627A5 (en)
DE (1) DE2442702C2 (en)
DK (1) DK144189C (en)
FI (1) FI260274A7 (en)
FR (1) FR2242986B1 (en)
GB (1) GB1447159A (en)
HU (1) HU171232B (en)
IE (1) IE40517B1 (en)
NL (1) NL7411739A (en)
SE (1) SE423632B (en)
YU (1) YU236574A (en)
ZA (1) ZA745326B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4205166A (en) * 1974-02-20 1980-05-27 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted-3-aminoalkyl-, acylaminoalkyl-, or hydroxyalkyl-substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
ZA76757B (en) * 1975-03-18 1977-01-26 Smithkline Corp New cephalosporin compounds
US4220644A (en) 1976-05-03 1980-09-02 Smithkline Corporation 7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins
US4118563A (en) * 1977-11-25 1978-10-03 Bristol-Myers Company Production of 7-(2-aminomethylphenylacetamido-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE36346B1 (en) * 1971-05-11 1976-10-13 R & L Molecular Research Ltd Antibacterial agents and a process for the preparation thereof
US3766175A (en) * 1971-05-11 1973-10-16 R & L Molecular Research Ltd Certain 7 - (o-aminomethylphenylacetamido) - 3-((heterocyclylthio)methyl)ceph-3-em-4-carboxylic acids

Also Published As

Publication number Publication date
DE2442702C2 (en) 1983-07-14
CA1031325A (en) 1978-05-16
IE40517B1 (en) 1979-06-20
DE2442702A1 (en) 1975-03-13
FI260274A7 (en) 1975-03-08
FR2242986B1 (en) 1978-07-21
HU171232B (en) 1977-12-28
NL7411739A (en) 1975-03-11
BE819541A (en) 1975-03-04
YU236574A (en) 1983-10-31
CH611627A5 (en) 1979-06-15
DK144189C (en) 1982-06-14
FR2242986A1 (en) 1975-04-04
GB1447159A (en) 1976-08-25
SE423632B (en) 1982-05-17
ZA745326B (en) 1975-08-27
SE7411147L (en) 1976-03-04
DK144189B (en) 1982-01-11
DK473274A (en) 1975-05-05
AU7284974A (en) 1976-03-04
JPS5062991A (en) 1975-05-29
US3910899A (en) 1975-10-07

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