IE40676L - Dibenzo (thiepino or oxepino-) -pyrrole compounds - Google Patents
Dibenzo (thiepino or oxepino-) -pyrrole compoundsInfo
- Publication number
- IE40676L IE40676L IE750357A IE35775A IE40676L IE 40676 L IE40676 L IE 40676L IE 750357 A IE750357 A IE 750357A IE 35775 A IE35775 A IE 35775A IE 40676 L IE40676 L IE 40676L
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- compounds
- prepared
- thiepino
- oxepino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical class O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000006193 diazotization reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1499727 2,3 - Dihydro - 1H - debenzo- [2,3; 6,7]thiepino- or oxepino-[4,5-c]-pyrroles CIBA-GEIGY AG 13 Feb 1975 [22 Feb 1974] 6150/75 Heading C2C Novel compounds I and salts thereof in which X is O or S, R is OH or alkanoyloxy and R 1 is C 1-7 alkyl or C 1-7 alkenyl are prepared by (1) reacting a compound II in which X 1 and X 2 are reactive esterified hydroxy groups with an amine R 1 NH 2 or (2) alkylating or alkenylating a compound IV compounds I (R = OH) are also prepared by hydrolysing a corresponding ether or ester derivative or by diazotization of a 5-amino group; compounds I (R = alkanoyloxy) are also prepared by acylating a compound I (R = OH); and a compound I obtained may be converted into the salts or a salt thereof converted to the corresponding free base. Compounds I have CNS-depressant and agitation-inhibiting activity and form with a carrier a pharmaceutical composition which may be administered orally or parenterally.
[GB1499727A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH254574A CH592095A5 (en) | 1974-02-22 | 1974-02-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40676L true IE40676L (en) | 1975-08-22 |
| IE40676B1 IE40676B1 (en) | 1979-08-01 |
Family
ID=4236198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE357/75A IE40676B1 (en) | 1974-02-22 | 1975-02-21 | Derivatives of 5-hydroxy-2,3-dihydro-1h-dibenzo-(2,3:6,7) thiepino and oxepino-(4,5c) pyrrole,methods for their preparation,and compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS50117800A (en) |
| AT (1) | AT341529B (en) |
| BE (1) | BE825801A (en) |
| CA (1) | CA1065871A (en) |
| CH (1) | CH592095A5 (en) |
| CS (1) | CS187461B2 (en) |
| DE (1) | DE2506155A1 (en) |
| DK (1) | DK143652B (en) |
| ES (1) | ES434955A1 (en) |
| FR (1) | FR2261762B1 (en) |
| GB (1) | GB1499727A (en) |
| HU (1) | HU169669B (en) |
| IE (1) | IE40676B1 (en) |
| IL (1) | IL46683A (en) |
| NL (1) | NL7501974A (en) |
| SE (1) | SE419991B (en) |
| ZA (1) | ZA751092B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH624105A5 (en) * | 1976-05-26 | 1981-07-15 | Ciba Geigy Ag | Process for the preparation of novel azatetracyclic compounds |
| EP0007450A1 (en) * | 1978-07-07 | 1980-02-06 | Ciba-Geigy Ag | Azatetracyclic carbonitriles, their preparation, pharmaceutical compositions containing them and their application |
| EP0030916B1 (en) * | 1979-12-10 | 1984-08-29 | Ciba-Geigy Ag | Azatetracyclic carbonitriles |
| FI841399A7 (en) * | 1983-04-12 | 1984-10-13 | Ciba Geigy Ag | Polycyclic carboxylic acid compounds, a method for their preparation and preparations containing these carboxylic acid compounds and their use. |
-
1974
- 1974-02-22 CH CH254574A patent/CH592095A5/xx not_active IP Right Cessation
-
1975
- 1975-01-30 SE SE7501012A patent/SE419991B/en unknown
- 1975-02-13 GB GB6150/75A patent/GB1499727A/en not_active Expired
- 1975-02-14 DE DE19752506155 patent/DE2506155A1/en not_active Withdrawn
- 1975-02-19 NL NL7501974A patent/NL7501974A/en not_active Application Discontinuation
- 1975-02-20 FR FR7505267A patent/FR2261762B1/fr not_active Expired
- 1975-02-20 HU HUCI1548A patent/HU169669B/hu unknown
- 1975-02-20 CA CA220,496A patent/CA1065871A/en not_active Expired
- 1975-02-21 AT AT132075A patent/AT341529B/en not_active IP Right Cessation
- 1975-02-21 CS CS751159A patent/CS187461B2/en unknown
- 1975-02-21 BE BE153577A patent/BE825801A/en unknown
- 1975-02-21 ZA ZA00751092A patent/ZA751092B/en unknown
- 1975-02-21 DK DK66175AA patent/DK143652B/en unknown
- 1975-02-21 IL IL46683A patent/IL46683A/en unknown
- 1975-02-21 ES ES434955A patent/ES434955A1/en not_active Expired
- 1975-02-21 IE IE357/75A patent/IE40676B1/en unknown
- 1975-02-22 JP JP50021470A patent/JPS50117800A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK66175A (en) | 1975-10-27 |
| AU7840075A (en) | 1976-08-26 |
| NL7501974A (en) | 1975-08-26 |
| FR2261762A1 (en) | 1975-09-19 |
| SE419991B (en) | 1981-09-07 |
| CS187461B2 (en) | 1979-01-31 |
| CA1065871A (en) | 1979-11-06 |
| IL46683A0 (en) | 1975-05-22 |
| GB1499727A (en) | 1978-02-01 |
| DK143652B (en) | 1981-09-21 |
| IE40676B1 (en) | 1979-08-01 |
| SE7501012L (en) | 1975-08-25 |
| JPS50117800A (en) | 1975-09-16 |
| HU169669B (en) | 1977-02-28 |
| CH592095A5 (en) | 1977-10-14 |
| ZA751092B (en) | 1976-01-28 |
| DE2506155A1 (en) | 1975-09-04 |
| ES434955A1 (en) | 1976-12-16 |
| IL46683A (en) | 1977-12-30 |
| ATA132075A (en) | 1977-06-15 |
| BE825801A (en) | 1975-08-21 |
| FR2261762B1 (en) | 1978-06-30 |
| AT341529B (en) | 1978-02-10 |
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