IE40821L - Antibiotic 67-121 from actinoplanes caeruleus - Google Patents
Antibiotic 67-121 from actinoplanes caeruleusInfo
- Publication number
- IE40821L IE40821L IE750491A IE49175A IE40821L IE 40821 L IE40821 L IE 40821L IE 750491 A IE750491 A IE 750491A IE 49175 A IE49175 A IE 49175A IE 40821 L IE40821 L IE 40821L
- Authority
- IE
- Ireland
- Prior art keywords
- antibiotic
- maxima
- complex
- absorption maxima
- free form
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 13
- 241000567047 Couchioplanes caeruleus Species 0.000 title 1
- 238000010521 absorption reaction Methods 0.000 abstract 8
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 6
- 239000002480 mineral oil Substances 0.000 abstract 4
- 235000010446 mineral oil Nutrition 0.000 abstract 4
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 241000187844 Actinoplanes Species 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000746 allylic group Chemical group 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000002459 polyene antibiotic agent Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- ZGEGCLOFRBLKSE-UHFFFAOYSA-N 1-Heptene Chemical compound CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 abstract 1
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000600 disaccharide group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1474879 Antibiotic complex SCHERICO Ltd 6 March 1975 [11 March 1974] 9392/75 Heading C2A The invention is directed to a polyene antibiotic complex designated 67-121 complex, in free form or in the form of a pharmaceutically acceptable derivative. The complex in the free form has the following characteristics; ultraviolet absorption maxima in methanol at 342, 363, 382 and 403 mÁ with corresponding E<SP>1%</SP> 1cm values of 340, 475, 667 and 605, infra-red absorption maxima in mineral oil at 3350, 1725 and 1665 cm<SP>-1</SP> and nuclear magnetic resonance spectra in hexa-deutero-dimethylsulfoxide with maxima at 2À75, 6À56 and 7À64 p.p.m. The complex comprises antibiotic components 67- 121A, 67-121B, 67-121C and 67-121D. The complex or a component antibiotic thereof may be prepared by cultivating a microorganism of the species Actinoplanes coerulus in a nutrient medium under aerobic conditions until substantial antibiotic activity is generated. The preferred microoganism is the strain Actinoplanes coeruleus NRRL 5325. Antibiotic 67-121A, in the free form has the following characteristics, ultra-violet absorption maxima in a 4 : 1 tetrahydrofuran : water mixture of 408, 384 and 363 mÁ with corresponding E<SP>1%</SP> 1cm values of 950, 1100 and 680; infra-red absorption maxima in mineral oil at 3350, 1725 and 1665 cm<SP>-1</SP> and a nuclear magnetic resonance spectrum in hexa-deutero-dimethylsulphoxide with maxima at 2À73, 6À55 and 7À64 p.p.m. Antibiotic 67-121B, in the free form has the following characteristics ultra-violet absorption maxima in a 4 : 1 tetra hydrofuran : water mixture of 408, 383 and 362 mÁ with corresponding E<SP>1%</SP> 1cm values of 620, 750 and 490; infra-red absorption maxima in mineral oil at 3350, 1725 and 1665 cm<SP>-1</SP> and a nuclear magnetic resonance spectrum in hexa-deutro dimethylsulphoxide with maxima at 6À58 and 7À60 p.p.m. Antibiotic 67-121C, in the free form has the following characteristics, ultraviolet absorption maxima in 4 : 1 tetrahydrofuran : water mixture of 408, 383 and 362 mÁ with corresponding E<SP>1%</SP> 1cm value of 800, 910 and 600; infra-red absorption maxima in mineral oil at 3350, 1725 and 1665 cm<SP>-1</SP> and a nuclear magnetic resonance spectrum in hexa-deutero dimethylsulphoxide with maxima at 2À76, 6À57 and 7À65 p.p.m. The polyene antibiotics are further characterized as a heptaene subgroup II antibiotic and having an aromatic moiety of the formula in which for antibiotics 67-121A and C, R is methyl and/or antibiotic 67-121B, R is H. The antibiotics 67-121A and 67-121B are further characterized by a presence of a D- mycosamine sugar unit glycosidically attached to an allylic hydroxy group of the aglycone structure and antibiotic 67-121C is further characterized by the presence of the disaccharide unit [O-#-D-mannopyranosyl(1#4)-D- mycosamine]glycosidically attached to an allylic hydroxy group of the aglycore structure. The complex or components may be in a free form or in the form of a pharmaceutically acceptable derivative. The antibiotic substances may be admixed with a suitable pharmaceutically acceptable carrier. The antibiotic substance may be administered to animals having a fungal infection to elicit an anti-fungal response therefrom.
[GB1474879A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45004074A | 1974-03-11 | 1974-03-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40821L true IE40821L (en) | 1975-09-11 |
| IE40821B1 IE40821B1 (en) | 1979-08-29 |
Family
ID=23786522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE491/75A IE40821B1 (en) | 1974-03-11 | 1975-03-06 | Antibiotic 67-121 and process for the preparation thereof |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS50121496A (en) |
| BG (1) | BG26542A3 (en) |
| DE (1) | DE2509782A1 (en) |
| FR (1) | FR2263782B1 (en) |
| GB (1) | GB1474879A (en) |
| HU (1) | HU175177B (en) |
| IE (1) | IE40821B1 (en) |
| NL (1) | NL7502666A (en) |
| SE (1) | SE7502535L (en) |
-
1975
- 1975-03-06 JP JP50027580A patent/JPS50121496A/ja active Pending
- 1975-03-06 FR FR7507083A patent/FR2263782B1/fr not_active Expired
- 1975-03-06 IE IE491/75A patent/IE40821B1/en unknown
- 1975-03-06 GB GB939275A patent/GB1474879A/en not_active Expired
- 1975-03-06 DE DE19752509782 patent/DE2509782A1/en active Pending
- 1975-03-06 NL NL7502666A patent/NL7502666A/en not_active Application Discontinuation
- 1975-03-10 HU HU75SCHE512A patent/HU175177B/en unknown
- 1975-03-11 BG BG029225A patent/BG26542A3/en unknown
- 1975-06-06 SE SE7502535*[A patent/SE7502535L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2263782A1 (en) | 1975-10-10 |
| IE40821B1 (en) | 1979-08-29 |
| SE7502535L (en) | 1975-10-03 |
| JPS50121496A (en) | 1975-09-23 |
| NL7502666A (en) | 1975-09-15 |
| HU175177B (en) | 1980-05-28 |
| FR2263782B1 (en) | 1978-12-01 |
| BG26542A3 (en) | 1979-04-12 |
| DE2509782A1 (en) | 1975-09-18 |
| GB1474879A (en) | 1977-05-25 |
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