IE41192L - Potentiated microbial compositions - Google Patents
Potentiated microbial compositionsInfo
- Publication number
- IE41192L IE41192L IE740177A IE17774A IE41192L IE 41192 L IE41192 L IE 41192L IE 740177 A IE740177 A IE 740177A IE 17774 A IE17774 A IE 17774A IE 41192 L IE41192 L IE 41192L
- Authority
- IE
- Ireland
- Prior art keywords
- compsns
- esp
- amt
- potentiated
- effective
- Prior art date
Links
- 230000000813 microbial effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 abstract 2
- MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 abstract 1
- 125000006083 1-bromoethyl group Chemical group 0.000 abstract 1
- NHZLNPMOSADWGC-UHFFFAOYSA-N 4-amino-N-(2-quinoxalinyl)benzenesulfonamide Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=CN=C(C=CC=C2)C2=N1 NHZLNPMOSADWGC-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000003495 Coccidiosis Diseases 0.000 abstract 1
- 229940117937 Dihydrofolate reductase inhibitor Drugs 0.000 abstract 1
- 206010023076 Isosporiasis Diseases 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229960004050 aminobenzoic acid Drugs 0.000 abstract 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- LDBTVAXGKYIFHO-UHFFFAOYSA-N diaveridine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=CN=C(N)N=C1N LDBTVAXGKYIFHO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003166 dihydrofolate reductase inhibitor Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000011835 investigation Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 244000144977 poultry Species 0.000 abstract 1
- CPNGPNLZQNNVQM-UHFFFAOYSA-N pteridine Chemical group N1=CN=CC2=NC=CN=C21 CPNGPNLZQNNVQM-UHFFFAOYSA-N 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 239000005460 tetrahydrofolate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compsns for the investigation and treatment of microbial systems or infections contain (a) a potentiating amt of a cpd of formula (I): (where (i) R is substd phenoxyalkyl or CHO and R1 and R2 are lower alkyl or together form a spirocycloalkyl ring with 4-6C atoms outside the pteridine ring, or (ii) R is CH2Cl and R1=R2=Me, or (iii) R is 1-bromoethyl and R1=R2=n-Pr) and (b) an effective amt of p-aminobenzoic acid competitor (e.g. a sulphonamide) and/or a dihydrofolatereductase inhibitor (e.g. a pyrimidine deriv). The compsns have a synergistic activity against bacteria and protozoa which produce at least part of their own tetrahydrofolate cofactor. They can be used as pharmaceuticals and in diagnosis and microorganism identification. Certain combinations (esp. of (I), sulphaquinoxaline and diaveridin) are esp. effective against coccidiosis in poultry.
[FR2215964A2]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB518873 | 1973-02-01 | ||
| GB518773A GB1472054A (en) | 1973-02-01 | 1973-02-01 | Potentiated microbial compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41192L true IE41192L (en) | 1974-08-01 |
| IE41192B1 IE41192B1 (en) | 1979-11-07 |
Family
ID=26239715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE177/74A IE41192B1 (en) | 1973-02-01 | 1974-01-31 | Potentiated microbial compositions |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS49102825A (en) |
| DE (1) | DE2404594A1 (en) |
| FR (1) | FR2215964A2 (en) |
| IE (1) | IE41192B1 (en) |
| IL (1) | IL44124A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU77364A1 (en) * | 1977-05-18 | 1979-01-19 | ||
| US9029344B2 (en) * | 2010-06-18 | 2015-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Linked purine pterin HPPK inhibitors useful as antibacterial agents |
| AU2017343643B2 (en) | 2016-10-11 | 2021-07-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HPPK inhibitors useful as antibacterial agents |
-
1974
- 1974-01-31 IE IE177/74A patent/IE41192B1/en unknown
- 1974-01-31 IL IL44124A patent/IL44124A/en unknown
- 1974-01-31 DE DE2404594A patent/DE2404594A1/en not_active Withdrawn
- 1974-01-31 JP JP49013251A patent/JPS49102825A/ja active Pending
- 1974-01-31 FR FR7403215A patent/FR2215964A2/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2215964B2 (en) | 1976-10-08 |
| IE41192B1 (en) | 1979-11-07 |
| IL44124A0 (en) | 1974-05-16 |
| AU6515574A (en) | 1975-08-07 |
| JPS49102825A (en) | 1974-09-28 |
| IL44124A (en) | 1977-10-31 |
| FR2215964A2 (en) | 1974-08-30 |
| DE2404594A1 (en) | 1974-08-15 |
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