IE41417L - Stabilized steroid formulations - Google Patents
Stabilized steroid formulationsInfo
- Publication number
- IE41417L IE41417L IE751175A IE117575A IE41417L IE 41417 L IE41417 L IE 41417L IE 751175 A IE751175 A IE 751175A IE 117575 A IE117575 A IE 117575A IE 41417 L IE41417 L IE 41417L
- Authority
- IE
- Ireland
- Prior art keywords
- polyethylene glycol
- weight
- compositions
- stabilized
- steroid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 150000003431 steroids Chemical class 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 5
- 229920001223 polyethylene glycol Polymers 0.000 abstract 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- 230000003078 antioxidant effect Effects 0.000 abstract 2
- 235000006708 antioxidants Nutrition 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- MBJJLHWSFGHIAA-UDCWSGSHSA-N (8s,9s,10r,13s,14s,17s)-10,13-dimethyl-17-(2,2,2-trihydroxyacetyl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)C(O)(O)O)[C@@H]4[C@@H]3CCC2=C1 MBJJLHWSFGHIAA-UDCWSGSHSA-N 0.000 abstract 1
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 abstract 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 abstract 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 abstract 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 abstract 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 abstract 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 abstract 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 abstract 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- XZUAPPXGIFNDRA-UHFFFAOYSA-N ethane-1,2-diamine;hydrate Chemical compound O.NCCN XZUAPPXGIFNDRA-UHFFFAOYSA-N 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000006210 lotion Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002480 mineral oil Substances 0.000 abstract 1
- 235000010446 mineral oil Nutrition 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 235000019271 petrolatum Nutrition 0.000 abstract 1
- -1 polyethylene Polymers 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 239000000473 propyl gallate Substances 0.000 abstract 1
- 235000010388 propyl gallate Nutrition 0.000 abstract 1
- 229940075579 propyl gallate Drugs 0.000 abstract 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 abstract 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 abstract 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 abstract 1
- 235000010262 sodium metabisulphite Nutrition 0.000 abstract 1
- 239000004296 sodium metabisulphite Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003871 white petrolatum Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1497836 Stabilized steroid compositions ER SQUIBB & SONS INC 29 May 1975 [13 June 1974] 23485/75 Heading A5B Stabilized steroid compositions useful in the treatment of inflammatory diseases of the skin and psoriasis comprises from 0.1% to 0.5% by weight of 9 α - fluoro - 21 - chloro - 11#, 16α, 17α, trihydroxypregn - 4 - ene - 3, 20 - dione, 16, 17 - acetonide, 0.005 to 0.2% by weight of an antioxidant selected from propyl gallate, butylated hydroxytoluene, butylated hydroxyanisole, sodium bisulphite, sodium metabisulphite and ascorbic acid; and polyethylene glycol or a polyethylene glycol ester both having a polyethylene glycol molecular weight of from 200 to 7500 may be prepared by dissolving the steroid and antioxidant in the polyethylene glycol or polyethylene glycol ester. The composition may further include an oleaginous material e.g. mineral oil thickened with polyethylene or white petrolatum, a chelating agent such as disodium ethylene diamine tetraacetic acid and/or water. The compositions may be applied topically in the form of lotions or ointments.
[GB1497836A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47898574A | 1974-06-13 | 1974-06-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41417L true IE41417L (en) | 1975-12-13 |
| IE41417B1 IE41417B1 (en) | 1980-01-02 |
Family
ID=23902198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1175/75A IE41417B1 (en) | 1974-06-13 | 1975-05-26 | Stabilized steroid formulations |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5126216A (en) |
| BE (1) | BE830239A (en) |
| CA (1) | CA1040534A (en) |
| DE (1) | DE2526251A1 (en) |
| FR (1) | FR2274310A1 (en) |
| GB (1) | GB1497836A (en) |
| IE (1) | IE41417B1 (en) |
| NL (1) | NL7506872A (en) |
| PH (1) | PH14507A (en) |
| YU (1) | YU152175A (en) |
| ZA (1) | ZA753429B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612306A (en) * | 1979-07-12 | 1981-02-06 | Nippon Zoki Pharmaceut Co Ltd | Novel base for external preparation |
| JPS56135416A (en) * | 1980-03-27 | 1981-10-22 | Mitsubishi Chem Ind Ltd | Pharmaceutical preparation for skin |
| CA2194371A1 (en) * | 1994-07-04 | 1996-01-18 | Thomas Backensfeld | Low-dose steroid tablets containing gallic acid esters as antioxidant agent, process for the manufacture of said tablets, and uses of said tablets |
| US7189759B2 (en) * | 2001-05-23 | 2007-03-13 | Medicis Pharmaceutical Corporation | Compositions for the treatment of pigmentation disorders and methods for their manufacture |
| DE102004059880A1 (en) * | 2004-12-10 | 2006-06-14 | Grünenthal GmbH | Stable, hormone-containing (intermediate) product |
| EP3253370A4 (en) * | 2015-02-05 | 2018-08-01 | Marc Selner | Ionic nanovesicle suspension and biocide prepared therefrom |
-
1975
- 1975-05-26 IE IE1175/75A patent/IE41417B1/en unknown
- 1975-05-27 ZA ZA00753429A patent/ZA753429B/en unknown
- 1975-05-28 CA CA227,942A patent/CA1040534A/en not_active Expired
- 1975-05-29 GB GB23485/75A patent/GB1497836A/en not_active Expired
- 1975-05-30 PH PH17207A patent/PH14507A/en unknown
- 1975-06-10 NL NL7506872A patent/NL7506872A/en not_active Application Discontinuation
- 1975-06-12 DE DE19752526251 patent/DE2526251A1/en not_active Ceased
- 1975-06-12 YU YU01521/75A patent/YU152175A/en unknown
- 1975-06-13 JP JP50072615A patent/JPS5126216A/en active Granted
- 1975-06-13 FR FR7518635A patent/FR2274310A1/en active Granted
- 1975-06-13 BE BE157333A patent/BE830239A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL7506872A (en) | 1975-12-16 |
| GB1497836A (en) | 1978-01-12 |
| IE41417B1 (en) | 1980-01-02 |
| JPS5747971B2 (en) | 1982-10-13 |
| ZA753429B (en) | 1976-04-28 |
| YU152175A (en) | 1983-10-31 |
| BE830239A (en) | 1975-10-01 |
| JPS5126216A (en) | 1976-03-04 |
| AU8168175A (en) | 1976-12-02 |
| PH14507A (en) | 1981-08-21 |
| FR2274310A1 (en) | 1976-01-09 |
| FR2274310B1 (en) | 1980-05-16 |
| DE2526251A1 (en) | 1976-01-02 |
| CA1040534A (en) | 1978-10-17 |
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