IE41426L - Stabilized polyalkylene glycols - Google Patents
Stabilized polyalkylene glycolsInfo
- Publication number
- IE41426L IE41426L IE751596A IE159675A IE41426L IE 41426 L IE41426 L IE 41426L IE 751596 A IE751596 A IE 751596A IE 159675 A IE159675 A IE 159675A IE 41426 L IE41426 L IE 41426L
- Authority
- IE
- Ireland
- Prior art keywords
- carbon atoms
- alkyl
- aggregate
- phenyl
- hydrogen
- Prior art date
Links
- 229920001515 polyalkylene glycol Polymers 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052740 iodine Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 102000003946 Prolactin Human genes 0.000 abstract 1
- 108010057464 Prolactin Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 239000000939 antiparkinson agent Substances 0.000 abstract 1
- 229940125688 antiparkinson agent Drugs 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229940097325 prolactin Drugs 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
8?-ERGOLINE I COMPOUNDS This invention provides new compounds of formula I, I wherein X is hydrogen, chlorine or bromine, R1 is methyl or ethyl, and R2 is CH2-CN, or a group NR3R4, wherein R3 is hydrogen or alkyl of 1 to 4 carbon atoms, and R4 is formyl, alkanoyl of 2 to 5 carbon atoms in the aggregate thereof, alkoxycarbonyl of 2 to 5 carbon atoms in the aggregate thereof, mono- to trihalogenalkoxycarbonyl of 3 to 5 carbon atoms in the aggregate thereof, the alkoxy radical of which is substituted by halogen in a position other than .alpha. to the oxygen, or the radical SO2R5, wherein R5 is alkyl of 1 to 4 carbon atoms, monoto tri-halogenalkyl of 1 to 4 carbon atoms, phenyl, pyridyl, phenyl monosubstituted by halogen or alkoxy of 1 to 4 carbon atoms, or a group NR6R7, wherein each of R6 and R7 is independently hydrogen or alkyl of 1 to 4 carbon atoms, or R6 and R7 together are one of the groups (CH2)n or (CH2)2-A-(CH2)2, wherein n is a number from 3 to 7, and A is oxygen, sulphur or nitrogen substituted by alkyl of 1 to 4 carbon atoms or phenyl, useful as prolactin secretion agents and antiparkinson agents.
[CA1073452A]
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE2048/78A IE41428B1 (en) | 1974-07-19 | 1975-07-17 | 6-methyl-8 -n,n-dimethyl sulphamoylaminoergoline i |
| IE2047/78A IE41427B1 (en) | 1974-07-19 | 1975-07-17 | 6-methyl-8 -cyanomethylergoline i |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH998374A CH605936A5 (en) | 1974-07-19 | 1974-07-19 | 8-Alpha-(Amino-or cyanomethyl)-ergoline derivs |
| CH1103174A CH605938A5 (en) | 1974-08-13 | 1974-08-13 | 8-Alpha-(Amino-or cyanomethyl)-ergoline derivs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41426L true IE41426L (en) | 1976-01-19 |
| IE41426B1 IE41426B1 (en) | 1980-01-02 |
Family
ID=25705648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1596/75A IE41426B1 (en) | 1974-07-19 | 1975-07-17 | 8 -substituted ergoline i derivatives |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5134199A (en) |
| AU (1) | AU505314B2 (en) |
| CA (1) | CA1073452A (en) |
| DD (1) | DD118635A5 (en) |
| DE (1) | DE2530577A1 (en) |
| DK (2) | DK143902C (en) |
| ES (1) | ES439548A1 (en) |
| FI (1) | FI61188C (en) |
| FR (1) | FR2282889A1 (en) |
| GB (3) | GB1517973A (en) |
| HK (2) | HK56880A (en) |
| IE (1) | IE41426B1 (en) |
| IL (1) | IL47735A (en) |
| MY (2) | MY8100217A (en) |
| NL (1) | NL7508416A (en) |
| NO (1) | NO752493L (en) |
| PH (1) | PH16594A (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1573621A (en) * | 1976-01-02 | 1980-08-28 | Sandoz Ltd | Acylated 6-methyl-8a-amino-ergoline i compounds |
| DE2656344A1 (en) * | 1975-12-23 | 1977-07-07 | Sandoz Ag | ERGOLIN DERIVATIVES, THEIR USE AND MANUFACTURING |
| IT1064473B (en) * | 1976-11-24 | 1985-02-18 | Simes | 8-BETA-AMINOMETHYLERGOLINE DERIVATIVES ON SULFAMOIL |
| WO1982000463A1 (en) * | 1980-07-25 | 1982-02-18 | Ag Sandoz | Ergoline derivatives,method for their preparation,pharmaceutical compositions containing them and their therapeutic application |
| BE889713A (en) * | 1980-07-25 | 1982-01-25 | Sandoz Sa | NEW ERGOLIN DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
| CH644606A5 (en) * | 1980-09-23 | 1984-08-15 | Sandoz Ag | METHOD FOR ISOMERIZING 9,10-DIHYDROLYSE ENERGY DERIVATIVES. |
| DE3101535A1 (en) * | 1981-01-14 | 1982-08-12 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | NEW (2-HALOGEN-ERGOLINYL) -N'.N'-DIETHYL-UREA DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT |
| JPS58174081A (en) * | 1982-04-05 | 1983-10-13 | Mitsubishi Heavy Ind Ltd | Ventilator for engine room of ship |
| HU197569B (en) * | 1984-01-12 | 1989-04-28 | Sandoz Ag | Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds |
| HU195810B (en) * | 1984-12-24 | 1988-07-28 | Sandoz Ag | Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds |
| NL8700046A (en) * | 1986-01-24 | 1987-08-17 | Sandoz Ag | 8 ALFA-ACYLAMINOERGOLINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. |
| AT392945B (en) * | 1988-06-27 | 1991-07-10 | Gerhard Mader Ges M B H Ing | STORAGE AND TRANSPORTATION CONTAINERS FOR Bulk goods and loose materials |
| DE4033496A1 (en) * | 1990-10-20 | 1992-04-23 | Sandoz Ag | NEW ERGOL DERIVATIVES, THEIR PRODUCTION AND USE |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3218323A (en) * | 1965-11-16 | Esters of i,g-dimethyl-b-ergolenyl carbamic acid | ||
| FR1360618A (en) * | 1963-06-17 | 1964-05-08 | Sandoz Sa | New urethanes of the lysergic series and their preparation |
| CH507248A (en) * | 1967-03-16 | 1971-05-15 | Spofa Vereinigte Pharma Werke | Process for the preparation of D-6-methylergolin (I) ylacetic acid |
| NL6818658A (en) * | 1968-01-18 | 1969-07-22 | ||
| AR206772A1 (en) * | 1972-07-21 | 1976-08-23 | Lilly Co Eli | PROCEDURE TO PREPARE A NEW D-2-HALO-6-METHYL-8-CYANE (CARBOXAMIDE) METHYL ERGOLINE |
-
1975
- 1975-07-04 GB GB4649/78A patent/GB1517973A/en not_active Expired
- 1975-07-04 GB GB4648/78A patent/GB1517972A/en not_active Expired
- 1975-07-04 GB GB28238/75A patent/GB1517971A/en not_active Expired
- 1975-07-09 DE DE19752530577 patent/DE2530577A1/en active Granted
- 1975-07-10 FI FI752011A patent/FI61188C/en not_active IP Right Cessation
- 1975-07-11 NO NO752493A patent/NO752493L/no unknown
- 1975-07-12 DK DK313175A patent/DK143902C/en not_active IP Right Cessation
- 1975-07-15 NL NL7508416A patent/NL7508416A/en not_active Application Discontinuation
- 1975-07-16 DD DD187329A patent/DD118635A5/xx unknown
- 1975-07-17 PH PH17392A patent/PH16594A/en unknown
- 1975-07-17 ES ES439548A patent/ES439548A1/en not_active Expired
- 1975-07-17 IE IE1596/75A patent/IE41426B1/en unknown
- 1975-07-17 AU AU83162/75A patent/AU505314B2/en not_active Expired
- 1975-07-18 CA CA231,773A patent/CA1073452A/en not_active Expired
- 1975-07-18 FR FR7522484A patent/FR2282889A1/en active Granted
- 1975-07-18 JP JP50087425A patent/JPS5134199A/ja active Pending
- 1975-07-18 IL IL47735A patent/IL47735A/en unknown
-
1980
- 1980-07-10 DK DK298980A patent/DK145542C/en not_active IP Right Cessation
- 1980-10-09 HK HK568/80A patent/HK56880A/en unknown
- 1980-10-09 HK HK569/80A patent/HK56980A/en unknown
-
1981
- 1981-12-30 MY MY217/81A patent/MY8100217A/en unknown
- 1981-12-30 MY MY215/81A patent/MY8100215A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL47735A (en) | 1979-11-30 |
| DD118635A5 (en) | 1976-03-12 |
| GB1517973A (en) | 1978-07-19 |
| GB1517971A (en) | 1978-07-19 |
| HK56980A (en) | 1980-10-16 |
| DK143902C (en) | 1982-04-13 |
| DK143902B (en) | 1981-10-26 |
| FI61188C (en) | 1982-06-10 |
| MY8100217A (en) | 1981-12-31 |
| CA1073452A (en) | 1980-03-11 |
| JPS5134199A (en) | 1976-03-23 |
| DE2530577A1 (en) | 1976-01-29 |
| AU505314B2 (en) | 1979-11-15 |
| PH16594A (en) | 1983-11-22 |
| NL7508416A (en) | 1976-01-21 |
| FR2282889B1 (en) | 1979-08-10 |
| HK56880A (en) | 1980-10-16 |
| FI61188B (en) | 1982-02-26 |
| IE41426B1 (en) | 1980-01-02 |
| NO752493L (en) | 1976-01-20 |
| DK298980A (en) | 1980-07-10 |
| AU8316275A (en) | 1977-01-20 |
| FR2282889A1 (en) | 1976-03-26 |
| MY8100215A (en) | 1981-12-31 |
| FI752011A7 (en) | 1976-01-20 |
| IL47735A0 (en) | 1975-10-15 |
| DK313175A (en) | 1976-01-20 |
| GB1517972A (en) | 1978-07-19 |
| ES439548A1 (en) | 1977-06-16 |
| DK145542B (en) | 1982-12-06 |
| DE2530577C2 (en) | 1990-11-08 |
| DK145542C (en) | 1983-05-02 |
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