IE41512L - 3, 4 - dihydro - 2h - isoquinolin - 1 - ones - Google Patents
3, 4 - dihydro - 2h - isoquinolin - 1 - onesInfo
- Publication number
- IE41512L IE41512L IE180275A IE180275A IE41512L IE 41512 L IE41512 L IE 41512L IE 180275 A IE180275 A IE 180275A IE 180275 A IE180275 A IE 180275A IE 41512 L IE41512 L IE 41512L
- Authority
- IE
- Ireland
- Prior art keywords
- chained
- branched
- radical
- hydrogen
- substituted
- Prior art date
Links
- YWPMKTWUFVOFPL-UHFFFAOYSA-N 3,4-dihydro-2h-isoquinolin-1-one Chemical class C1=CC=C2C(=O)NCCC2=C1 YWPMKTWUFVOFPL-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000033764 rhythmic process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
this invention relates to 3,4-aihydro-2H-isoquinoline-l-ones of the formula (X) wherein X1 represents hydrogen, a saturated or unsaturated, sraight-chained or branched alkyl radical having 1 to 6 carbon atoms or the phenyl radical, R2 represents a dialkylaminoalkyl radical of the formula wherein A represents a straight-chained or branched low molecular alkylene group and R5 and R6 are identical or different and represent straight-chained or branched, low molecular alkyl radicals and may form together with the nitrogen atom a 5-, 6or 7-membered ring, wherein one of the hydrocarbons is substituted by a hetero atom which may be substituted with hydrogen, C1-C4 alkyl or the phenyl radical, R3 and R4 are identical or different and represent hydrogen or a lower alkoxy group having 1 to 4 carbon atoms, and the physiologically tolerable salts thereof. The compounds have an antiarrhythmic activity and are suitable for treating disturbances of cardiac rhythm.
[CA1055027A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742438966 DE2438966A1 (en) | 1974-08-14 | 1974-08-14 | BASIC SUBSTITUTES 3, 4-DIHYDRO2H-ISOCHINOLIN-1-ONE AND THE PROCESS FOR THEIR PRODUCTION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41512L true IE41512L (en) | 1976-02-14 |
| IE41512B1 IE41512B1 (en) | 1980-01-16 |
Family
ID=5923161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE180275A IE41512B1 (en) | 1974-08-14 | 1975-08-13 | 3,4-dihydro-2h-isoquinoline-1-ones and process for preparing them |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5143767A (en) |
| AT (1) | AT349019B (en) |
| BE (1) | BE832470A (en) |
| CA (1) | CA1055027A (en) |
| DE (1) | DE2438966A1 (en) |
| DK (1) | DK367175A (en) |
| FR (1) | FR2281763A1 (en) |
| GB (1) | GB1516535A (en) |
| IE (1) | IE41512B1 (en) |
| LU (1) | LU73197A1 (en) |
| NL (1) | NL7509486A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58203968A (en) * | 1982-05-21 | 1983-11-28 | Otsuka Pharmaceut Co Ltd | Isocarbostyryl derivative |
| CN101663262B (en) * | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | N-(3-benzyl)-2,2-(diphenyl)-propan-1amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2143744A1 (en) * | 1971-09-01 | 1973-03-08 | Hoechst Ag | 3,4-DIHYDRO-2H-ISOCHINOLIN-1-ONE AND THE METHOD FOR MANUFACTURING IT |
-
1974
- 1974-08-14 DE DE19742438966 patent/DE2438966A1/en active Pending
-
1975
- 1975-08-08 NL NL7509486A patent/NL7509486A/en unknown
- 1975-08-12 LU LU73197A patent/LU73197A1/xx unknown
- 1975-08-13 AT AT629775A patent/AT349019B/en not_active IP Right Cessation
- 1975-08-13 DK DK367175A patent/DK367175A/en not_active Application Discontinuation
- 1975-08-13 IE IE180275A patent/IE41512B1/en unknown
- 1975-08-13 CA CA233,696A patent/CA1055027A/en not_active Expired
- 1975-08-14 GB GB3388975A patent/GB1516535A/en not_active Expired
- 1975-08-14 BE BE159241A patent/BE832470A/en unknown
- 1975-08-14 FR FR7525344A patent/FR2281763A1/en active Granted
- 1975-08-14 JP JP9904375A patent/JPS5143767A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATA629775A (en) | 1978-08-15 |
| DE2438966A1 (en) | 1976-03-04 |
| IE41512B1 (en) | 1980-01-16 |
| LU73197A1 (en) | 1977-04-13 |
| CA1055027A (en) | 1979-05-22 |
| GB1516535A (en) | 1978-07-05 |
| DK367175A (en) | 1976-02-15 |
| BE832470A (en) | 1976-02-16 |
| JPS5143767A (en) | 1976-04-14 |
| NL7509486A (en) | 1976-02-17 |
| FR2281763A1 (en) | 1976-03-12 |
| FR2281763B1 (en) | 1978-09-01 |
| AT349019B (en) | 1979-03-12 |
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