IE41561L - Enzymatic deacylation of penicillin derivatives - Google Patents
Enzymatic deacylation of penicillin derivativesInfo
- Publication number
- IE41561L IE41561L IE751356A IE135675A IE41561L IE 41561 L IE41561 L IE 41561L IE 751356 A IE751356 A IE 751356A IE 135675 A IE135675 A IE 135675A IE 41561 L IE41561 L IE 41561L
- Authority
- IE
- Ireland
- Prior art keywords
- penicillin derivatives
- enzymatic deacylation
- deacylation
- deacylate
- penam
- Prior art date
Links
- 230000020176 deacylation Effects 0.000 title abstract 2
- 238000005947 deacylation reaction Methods 0.000 title abstract 2
- 230000002255 enzymatic effect Effects 0.000 title 1
- 150000002960 penicillins Chemical class 0.000 title 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical group N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 4
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Substances C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 abstract 2
- 229930195708 Penicillin V Natural products 0.000 abstract 2
- 229940056360 penicillin g Drugs 0.000 abstract 2
- 229940056367 penicillin v Drugs 0.000 abstract 2
- AWRSDQGCXNOXOC-NUWLTMBBSA-N (5r)-6-amino-3,3-dimethyl-2-(2h-tetrazol-5-yl)-4-thia-1-azabicyclo[3.2.0]heptan-7-one Chemical compound NC([C@H]1SC2(C)C)C(=O)N1C2C=1N=NNN=1 AWRSDQGCXNOXOC-NUWLTMBBSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WSHJJCPTKWSMRR-RXMQYKEDSA-N penam Chemical compound S1CCN2C(=O)C[C@H]21 WSHJJCPTKWSMRR-RXMQYKEDSA-N 0.000 abstract 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 abstract 1
- -1 phenoxymethylpenicillin tetrazoles Chemical class 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/84—Penicillin amidase (3.5.1.11)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/823—Acetobacter
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/83—Arthrobacter
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/839—Bacillus subtilis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/873—Proteus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Deacylation of benzyl- and phenoxymethylpenicillin tetrazoles to produce 6-amino-2,2-dimethyl-3-(tetrazol-5-yl)penam by the use of selected deacylases. The process is useful in the purification of said penam which is a valuable synthetic intermediate. It has been found that those enzymes which will deacylate benzyl- and phenoxymethylpenicillin will generally deacylate the corresponding tetrazoles.
[US3905868A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US529480A US3905868A (en) | 1974-12-04 | 1974-12-04 | Enzymatic deacylation of benzyl- and phenoxymethylpenicillin tetrazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41561L true IE41561L (en) | 1976-06-04 |
| IE41561B1 IE41561B1 (en) | 1980-01-30 |
Family
ID=24110086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1356/75A IE41561B1 (en) | 1974-12-04 | 1975-06-17 | Enzymatic deacylation of benzyl- and phenoxymethylpenicillin tetrazoles |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3905868A (en) |
| JP (1) | JPS5198297A (en) |
| BE (1) | BE832144A (en) |
| DE (1) | DE2533820A1 (en) |
| DK (1) | DK358575A (en) |
| FR (1) | FR2309557A1 (en) |
| GB (1) | GB1481760A (en) |
| IE (1) | IE41561B1 (en) |
| LU (1) | LU73181A1 (en) |
| NL (1) | NL7508961A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4113566A (en) * | 1976-11-26 | 1978-09-12 | Pfizer Inc. | Process for preparing 6-aminopenicillanic acid |
| US5155029A (en) * | 1989-08-28 | 1992-10-13 | International Flavors & Fragrances Inc. | Process for producing a cyclic ether |
| US4970163A (en) * | 1989-08-28 | 1990-11-13 | International Flavors & Fragrances Inc. | Process for producing diol and lactone and microorganisms capable of same |
| US5212078A (en) * | 1989-08-28 | 1993-05-18 | International Flavors And Fragrances Inc. | Process for producing a lactone |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3736230A (en) * | 1969-02-17 | 1973-05-29 | P Delin | Process for producing 6-amino-penicillanic acid |
-
1974
- 1974-12-04 US US529480A patent/US3905868A/en not_active Expired - Lifetime
-
1975
- 1975-06-17 IE IE1356/75A patent/IE41561B1/en unknown
- 1975-07-28 NL NL7508961A patent/NL7508961A/en not_active Application Discontinuation
- 1975-07-29 DE DE19752533820 patent/DE2533820A1/en active Pending
- 1975-07-30 JP JP50092184A patent/JPS5198297A/en active Pending
- 1975-08-06 BE BE1006815A patent/BE832144A/en unknown
- 1975-08-07 DK DK358575A patent/DK358575A/en unknown
- 1975-08-07 FR FR7524675A patent/FR2309557A1/en active Granted
- 1975-08-08 LU LU73181A patent/LU73181A1/xx unknown
- 1975-12-04 GB GB49896/75A patent/GB1481760A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE41561B1 (en) | 1980-01-30 |
| FR2309557A1 (en) | 1976-11-26 |
| BE832144A (en) | 1976-02-06 |
| FR2309557B1 (en) | 1977-12-16 |
| LU73181A1 (en) | 1976-08-13 |
| NL7508961A (en) | 1976-06-09 |
| US3905868A (en) | 1975-09-16 |
| JPS5198297A (en) | 1976-08-30 |
| GB1481760A (en) | 1977-08-03 |
| DE2533820A1 (en) | 1976-06-16 |
| DK358575A (en) | 1976-06-05 |
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