IE41562L - Indolinone and fluorenone derivatives - Google Patents

Indolinone and fluorenone derivatives

Info

Publication number
IE41562L
IE41562L IE751359A IE135975A IE41562L IE 41562 L IE41562 L IE 41562L IE 751359 A IE751359 A IE 751359A IE 135975 A IE135975 A IE 135975A IE 41562 L IE41562 L IE 41562L
Authority
IE
Ireland
Prior art keywords
indolinone
fluorenone
het
fluorenone derivatives
june
Prior art date
Application number
IE751359A
Other versions
IE41562B1 (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH838074A external-priority patent/CH599160A5/en
Priority claimed from CH838174A external-priority patent/CH602710A5/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE41562L publication Critical patent/IE41562L/en
Publication of IE41562B1 publication Critical patent/IE41562B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/10—Radicals substituted by singly bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1500063 2-Indolinone and fluorenone derivatives SANDOZ Ltd 16 June 1975 [19 June 1974 (2)] 25530/75 Heading C2C Novel 2-indolinone and fluorenone derivatives of the general formula wherein Het is a radical formed by removing a hydrogen atom from the phenyl ring of 2-indolinone or fluorenone, and R is a group having one of the following Formulµ A, B, C and D in which n is 2 or 3, n<SP>1</SP> is 1-4, X-X<SP>1</SP> is ethylene or vinylene and in D the two C atoms adjacent to the N atom are identically unsubstituted or substituted by one or two C 1-4 alkyl groups and acid addition salts thereof are prepared by reacting Het-O-CH 2 -CH(OH)-CH 2 Y, in which Y is a leaving group, or an epoxy compound of the general Formula IIa with H-R, followed optionally by salification of the product. Pharmaceutical compositions having antiarrhythmic activity comprise, as active ingredient, a 2-indolinone or fluorenone derivative (I) or a pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutical carrier or diluent. [GB1500063A]
IE1359/75A 1974-06-19 1975-06-17 Indolinone and fluorenone derivatives IE41562B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH838074A CH599160A5 (en) 1974-06-19 1974-06-19 Substd. 9-fluorenone and 2-indolinone derivs
CH838174A CH602710A5 (en) 1974-06-19 1974-06-19 Substd. 9-fluorenone and 2-indolinone derivs

Publications (2)

Publication Number Publication Date
IE41562L true IE41562L (en) 1975-12-19
IE41562B1 IE41562B1 (en) 1980-01-30

Family

ID=25703229

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1359/75A IE41562B1 (en) 1974-06-19 1975-06-17 Indolinone and fluorenone derivatives

Country Status (18)

Country Link
JP (1) JPS51125060A (en)
AT (1) ATA466375A (en)
AU (1) AU8216875A (en)
CA (1) CA1036163A (en)
DD (1) DD118086A5 (en)
DE (1) DE2525656A1 (en)
DK (1) DK259475A (en)
ES (1) ES438637A1 (en)
FI (1) FI751727A7 (en)
FR (1) FR2275200A1 (en)
GB (1) GB1500063A (en)
HU (1) HU169926B (en)
IE (1) IE41562B1 (en)
IL (1) IL47503A0 (en)
NL (1) NL7507131A (en)
NO (1) NO752078L (en)
SE (1) SE7506757L (en)
SU (1) SU583755A3 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005828B1 (en) * 1978-06-06 1981-03-11 Hoechst Aktiengesellschaft New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
HK1045157A1 (en) 1999-01-22 2002-11-15 依兰制药公司 Compounds which inhibit leukocyte adhesion mediated by vla-4
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
ZA200803016B (en) 2005-09-29 2009-10-28 Elan Pharmaceuticals Inc Wyeth Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4
ATE493405T1 (en) 2005-09-29 2011-01-15 Elan Pharm Inc PYRIMIDINYLAMIDE COMPOUNDS THAT INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4
EA017110B1 (en) 2006-02-27 2012-09-28 Элан Фамэсьютикэлс, Инк. PYRIMIDINYLSULFONAMIDE COMPOUNDS (VARIANTS), METHOD FOR PREPARING SAME (VARIANTS), PHARMACEUTICAL COMPOSITION, METHOD FOR TREATING A DISEASE MEDIATED BY α4 INTEGRIN, METHOD FOR REDUCING AND/OR PREVENTING AN INFLAMMATORY COMPONENT OF A DISEASE OR AN AUTOIMMUNE RESPONSE
SG10201401836RA (en) 2009-04-27 2014-10-30 Elan Pharm Inc Pyridinone antagonists of alpha-4 integrins

Also Published As

Publication number Publication date
NO752078L (en) 1975-12-22
ES438637A1 (en) 1977-06-01
SU583755A3 (en) 1977-12-05
DK259475A (en) 1975-12-20
DD118086A5 (en) 1976-02-12
ATA466375A (en) 1979-08-15
HU169926B (en) 1977-02-28
NL7507131A (en) 1975-12-23
FR2275200A1 (en) 1976-01-16
CA1036163A (en) 1978-08-08
AU8216875A (en) 1976-12-23
FR2275200B1 (en) 1979-06-08
GB1500063A (en) 1978-02-08
IE41562B1 (en) 1980-01-30
DE2525656A1 (en) 1976-01-15
FI751727A7 (en) 1975-12-20
IL47503A0 (en) 1975-08-31
SE7506757L (en) 1975-12-22
JPS51125060A (en) 1976-11-01

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