IE41622L - Carboxy acetamidocephalosporins - Google Patents
Carboxy acetamidocephalosporinsInfo
- Publication number
- IE41622L IE41622L IE751145A IE114575A IE41622L IE 41622 L IE41622 L IE 41622L IE 751145 A IE751145 A IE 751145A IE 114575 A IE114575 A IE 114575A IE 41622 L IE41622 L IE 41622L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- tert
- butyl
- converting
- monoester
- Prior art date
Links
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 Cephem compounds Chemical class 0.000 abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1457237 Cephem compounds RECHERCHE ET INDUSTRIE THERAPEUTIQUES 21 May 1975 [22 May 1974 2 Jan 1975] 21816/75 Heading C2C The invention comprises compounds of formula and their non-toxic pharmaceutically acceptable salts. In examples, these compounds are prepared by converting benzyl or tert-butyl thienylacetate to the corresponding malonate monoester, converting this to monobenzyl (or tert - butyl)mono(2,5 - dioxopyrrolidin - 1 - yl)- thienylmalonate, reacting the latter with the corresponding amino / methyltetrazolylthiomethyl cephen compound, and finally hydrolysing the thus-formed side-chain monoester of I. Thereapeutic compositions having antibacterial activity comprise compounds of the above formula and may be administered by injection.
[GB1457237A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47226374A | 1974-05-22 | 1974-05-22 | |
| US53798775A | 1975-01-02 | 1975-01-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41622L true IE41622L (en) | 1975-11-22 |
| IE41622B1 IE41622B1 (en) | 1980-02-13 |
Family
ID=27043712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1145/75A IE41622B1 (en) | 1974-05-22 | 1975-05-22 | Cephalosporin compounds |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS511489A (en) |
| AU (1) | AU8059475A (en) |
| CA (1) | CA1041087A (en) |
| DE (1) | DE2521062A1 (en) |
| DK (1) | DK203575A (en) |
| ES (1) | ES437182A1 (en) |
| FR (1) | FR2271827A1 (en) |
| GB (1) | GB1457237A (en) |
| IE (1) | IE41622B1 (en) |
| IL (1) | IL47176A0 (en) |
| LU (1) | LU72530A1 (en) |
| NL (1) | NL7505962A (en) |
| SE (1) | SE7504669L (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5321191A (en) * | 1976-08-10 | 1978-02-27 | Shionogi & Co Ltd | 7-arylmalonamidocephem derivatives |
| JPS60215690A (en) * | 1984-04-09 | 1985-10-29 | Meiji Seika Kaisha Ltd | Cephalosporin compound and antibacterial agent containing said compound as active component |
-
1975
- 1975-04-23 SE SE7504669A patent/SE7504669L/en unknown
- 1975-04-25 IL IL47176A patent/IL47176A0/en unknown
- 1975-04-28 AU AU80594/75A patent/AU8059475A/en not_active Expired
- 1975-04-29 ES ES437182A patent/ES437182A1/en not_active Expired
- 1975-04-29 FR FR7513352A patent/FR2271827A1/fr not_active Withdrawn
- 1975-05-07 DK DK203575A patent/DK203575A/en unknown
- 1975-05-12 DE DE19752521062 patent/DE2521062A1/en active Pending
- 1975-05-20 LU LU72530A patent/LU72530A1/xx unknown
- 1975-05-20 CA CA227,351A patent/CA1041087A/en not_active Expired
- 1975-05-21 GB GB2181675A patent/GB1457237A/en not_active Expired
- 1975-05-21 NL NL7505962A patent/NL7505962A/en unknown
- 1975-05-22 IE IE1145/75A patent/IE41622B1/en unknown
- 1975-05-22 JP JP50061783A patent/JPS511489A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2271827A1 (en) | 1975-12-19 |
| JPS511489A (en) | 1976-01-08 |
| DE2521062A1 (en) | 1975-12-04 |
| NL7505962A (en) | 1975-11-25 |
| SE7504669L (en) | 1975-11-24 |
| CA1041087A (en) | 1978-10-24 |
| AU8059475A (en) | 1976-11-04 |
| DK203575A (en) | 1975-11-23 |
| IE41622B1 (en) | 1980-02-13 |
| ES437182A1 (en) | 1977-01-16 |
| GB1457237A (en) | 1976-12-01 |
| LU72530A1 (en) | 1975-10-08 |
| IL47176A0 (en) | 1975-06-25 |
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