IE41667L - Phenylpiperazine compounds - Google Patents
Phenylpiperazine compoundsInfo
- Publication number
- IE41667L IE41667L IE751929A IE192975A IE41667L IE 41667 L IE41667 L IE 41667L IE 751929 A IE751929 A IE 751929A IE 192975 A IE192975 A IE 192975A IE 41667 L IE41667 L IE 41667L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- lowering
- appropriately substituted
- compounds
- action
- Prior art date
Links
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- SNMVRZFUUCLYTO-UHFFFAOYSA-N n-propyl chloride Chemical class CCCCl SNMVRZFUUCLYTO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Novel substituted N-[1-(3,4-methylenedioxyphenyl)-propyl-(2)]-N'-phenylpiperazines of the formula I shown, wherein either R1 and R2 denote chlorine or R1 denotes methyl and R2 denotes methoxy, are prepared by treating an appropriately substituted halogenopropane, especially an appropriately substituted chloropropane, with catalytically activated hydrogen. Advantageously, the process is carried out in the presence of an acid-binding agent and at an elevated temperature. The compounds of the formula I may be obtained in the form of the racemates or of the optically active antipodes. The products of the process show a good central-depressant action as well as an excellent blood lipid level-lowering and cholesterol-lowering action. <IMAGE>
[GB1514546A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2442158A DE2442158C3 (en) | 1974-09-03 | 1974-09-03 | New substituted N- [1 (3,4-methylenedioxyphenyl) propyl (2)] -N'-subst phenylpiperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41667L true IE41667L (en) | 1976-03-03 |
| IE41667B1 IE41667B1 (en) | 1980-02-27 |
Family
ID=5924765
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1930/75A IE43338B1 (en) | 1974-09-03 | 1975-09-03 | Pharmaceutical compositions |
| IE1929/75A IE41667B1 (en) | 1974-09-03 | 1975-09-03 | Substituted phenylpiperazine compounds and pharmaceutical uses thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1930/75A IE43338B1 (en) | 1974-09-03 | 1975-09-03 | Pharmaceutical compositions |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS52287A (en) |
| AT (1) | AT344699B (en) |
| BE (2) | BE833003A (en) |
| BG (1) | BG26381A3 (en) |
| CA (2) | CA1063027A (en) |
| CH (1) | CH615174A5 (en) |
| CS (1) | CS192521B2 (en) |
| DD (1) | DD124118A5 (en) |
| DE (1) | DE2442158C3 (en) |
| DK (1) | DK137387C (en) |
| ES (5) | ES440630A1 (en) |
| FI (1) | FI60006C (en) |
| FR (1) | FR2283682A1 (en) |
| GB (3) | GB1514546A (en) |
| HU (1) | HU176754B (en) |
| IE (2) | IE43338B1 (en) |
| IL (2) | IL48033A (en) |
| LU (2) | LU73317A1 (en) |
| NL (1) | NL7510319A (en) |
| NO (1) | NO142911C (en) |
| NZ (1) | NZ178566A (en) |
| PH (1) | PH13631A (en) |
| PL (1) | PL95233B1 (en) |
| RO (1) | RO68380B (en) |
| SE (1) | SE419084B (en) |
| YU (1) | YU37164B (en) |
| ZA (2) | ZA755602B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54109307U (en) * | 1978-01-19 | 1979-08-01 | ||
| US4647606A (en) * | 1982-12-27 | 1987-03-03 | Owens-Corning Fiberglas Corporation | Blend of rapid set asphaltic emulsion with slow set asphalt emulsion |
| HU187229B (en) * | 1983-04-14 | 1985-11-28 | Koezponti Valto Hitelbank | Method for producing fodder increasing yield or additional fodder composition |
| AUPN359095A0 (en) * | 1995-06-19 | 1995-07-13 | Mount Shamrock Pty Ltd | Saw system |
-
1974
- 1974-09-03 DE DE2442158A patent/DE2442158C3/en not_active Expired
-
1975
- 1975-08-13 FI FI752288A patent/FI60006C/en not_active IP Right Cessation
- 1975-08-25 AT AT653875A patent/AT344699B/en not_active IP Right Cessation
- 1975-08-28 RO RO83281A patent/RO68380B/en unknown
- 1975-09-01 DD DD188118A patent/DD124118A5/xx unknown
- 1975-09-01 BG BG030900A patent/BG26381A3/en unknown
- 1975-09-01 CS CS755930A patent/CS192521B2/en unknown
- 1975-09-02 DK DK393775A patent/DK137387C/en active
- 1975-09-02 BE BE159687A patent/BE833003A/en not_active IP Right Cessation
- 1975-09-02 PL PL1975183066A patent/PL95233B1/pl unknown
- 1975-09-02 IL IL48033A patent/IL48033A/en unknown
- 1975-09-02 SE SE7509746A patent/SE419084B/en unknown
- 1975-09-02 ES ES440630A patent/ES440630A1/en not_active Expired
- 1975-09-02 BE BE159686A patent/BE833002A/en not_active IP Right Cessation
- 1975-09-02 JP JP50106441A patent/JPS52287A/en active Pending
- 1975-09-02 GB GB36152/75A patent/GB1514546A/en not_active Expired
- 1975-09-02 YU YU2219/75A patent/YU37164B/en unknown
- 1975-09-02 NO NO753020A patent/NO142911C/en unknown
- 1975-09-02 HU HU75BO1570A patent/HU176754B/en unknown
- 1975-09-02 NL NL7510319A patent/NL7510319A/en not_active Application Discontinuation
- 1975-09-02 GB GB36147/75A patent/GB1521051A/en not_active Expired
- 1975-09-02 GB GB3218/78A patent/GB1521052A/en not_active Expired
- 1975-09-02 IL IL48036A patent/IL48036A/en unknown
- 1975-09-03 LU LU73317A patent/LU73317A1/xx unknown
- 1975-09-03 IE IE1930/75A patent/IE43338B1/en unknown
- 1975-09-03 NZ NZ178566A patent/NZ178566A/en unknown
- 1975-09-03 CA CA234,708A patent/CA1063027A/en not_active Expired
- 1975-09-03 CA CA234,707A patent/CA1061343A/en not_active Expired
- 1975-09-03 PH PH17540A patent/PH13631A/en unknown
- 1975-09-03 IE IE1929/75A patent/IE41667B1/en unknown
- 1975-09-03 ZA ZA755602A patent/ZA755602B/en unknown
- 1975-09-03 LU LU73316A patent/LU73316A1/xx unknown
- 1975-09-03 ZA ZA755601A patent/ZA755601B/en unknown
- 1975-09-03 FR FR7527056A patent/FR2283682A1/en active Granted
-
1976
- 1976-12-03 ES ES453934A patent/ES453934A1/en not_active Expired
- 1976-12-03 ES ES453932A patent/ES453932A1/en not_active Expired
- 1976-12-03 ES ES453933A patent/ES453933A1/en not_active Expired
- 1976-12-03 ES ES453935A patent/ES453935A1/en not_active Expired
-
1979
- 1979-05-07 CH CH425779A patent/CH615174A5/en not_active IP Right Cessation
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