IE41788L - Phenylbutazone derivatives - Google Patents
Phenylbutazone derivativesInfo
- Publication number
- IE41788L IE41788L IE751861A IE186175A IE41788L IE 41788 L IE41788 L IE 41788L IE 751861 A IE751861 A IE 751861A IE 186175 A IE186175 A IE 186175A IE 41788 L IE41788 L IE 41788L
- Authority
- IE
- Ireland
- Prior art keywords
- phenylbutazone
- compounds
- heterocyclic radical
- derivatives
- gb1482380a
- Prior art date
Links
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical class O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 title abstract 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 abstract 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 208000025747 Rheumatic disease Diseases 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229960002895 phenylbutazone Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel phenylbutazone derivatives of the accompanying formula I, in which R represents an alkyl radical having 1 to 5 carbon atoms or a heterocyclic radical, preferably the heterocyclic radical of nicotinic or isonicotinic acid, are prepared by reaction of phenylbutazone with L- or D,L-proline whose N atom is protected by the -COR group. The compounds are distinguished by a good anti-inflammatory action, the undesired side effects being very low. The compounds can be used for medicaments for the treatment of rheumatic disorders. <IMAGE>
[GB1482380A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7429109A FR2282884A1 (en) | 1974-08-26 | 1974-08-26 | NEW DERIVATIVES OF PHENYLBUTAZONE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41788L true IE41788L (en) | 1976-02-26 |
| IE41788B1 IE41788B1 (en) | 1980-03-26 |
Family
ID=9142574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1861/75A IE41788B1 (en) | 1974-08-26 | 1975-08-25 | Phenylbutazone derivatives |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT343111B (en) |
| BE (1) | BE832722A (en) |
| CH (1) | CH615434A5 (en) |
| DE (1) | DE2537590A1 (en) |
| DK (1) | DK138495B (en) |
| FI (1) | FI61893C (en) |
| FR (1) | FR2282884A1 (en) |
| GB (1) | GB1482380A (en) |
| IE (1) | IE41788B1 (en) |
| LU (1) | LU73250A1 (en) |
| NL (1) | NL7509999A (en) |
| NO (1) | NO142220C (en) |
| SE (1) | SE421618B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1604045A (en) * | 1977-06-01 | 1981-12-02 | Sterwin Ag | -(2-methyl-indol-3-yl)-acetic acid esters processes for its prepartion and pharmaceutical compositions incorporating the same |
-
1974
- 1974-08-26 FR FR7429109A patent/FR2282884A1/en active Granted
-
1975
- 1975-08-22 AT AT650175A patent/AT343111B/en not_active IP Right Cessation
- 1975-08-23 DE DE19752537590 patent/DE2537590A1/en not_active Ceased
- 1975-08-25 FI FI752387A patent/FI61893C/en not_active IP Right Cessation
- 1975-08-25 IE IE1861/75A patent/IE41788B1/en unknown
- 1975-08-25 LU LU73250A patent/LU73250A1/xx unknown
- 1975-08-25 NO NO752923A patent/NO142220C/en unknown
- 1975-08-25 BE BE159444A patent/BE832722A/en not_active IP Right Cessation
- 1975-08-25 DK DK381075AA patent/DK138495B/en unknown
- 1975-08-25 NL NL7509999A patent/NL7509999A/en unknown
- 1975-08-25 SE SE7509449A patent/SE421618B/en unknown
- 1975-08-26 CH CH1107275A patent/CH615434A5/en not_active IP Right Cessation
- 1975-08-26 GB GB35252/75A patent/GB1482380A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE832722A (en) | 1976-02-25 |
| FR2282884A1 (en) | 1976-03-26 |
| FI61893B (en) | 1982-06-30 |
| NL7509999A (en) | 1976-03-01 |
| SE421618B (en) | 1982-01-18 |
| FR2282884B1 (en) | 1978-07-21 |
| LU73250A1 (en) | 1977-01-07 |
| DK138495B (en) | 1978-09-18 |
| ATA650175A (en) | 1977-09-15 |
| NO752923L (en) | 1976-02-27 |
| AT343111B (en) | 1978-05-10 |
| FI61893C (en) | 1982-10-11 |
| NO142220C (en) | 1980-07-16 |
| GB1482380A (en) | 1977-08-10 |
| DE2537590A1 (en) | 1976-03-11 |
| FI752387A7 (en) | 1976-02-27 |
| DK381075A (en) | 1976-02-27 |
| DK138495C (en) | 1979-03-05 |
| SE7509449L (en) | 1976-02-27 |
| CH615434A5 (en) | 1980-01-31 |
| IE41788B1 (en) | 1980-03-26 |
| NO142220B (en) | 1980-04-08 |
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