IE41879L - Process for the optical purification of¹d-p-hydroxyphenylglycine - Google Patents
Process for the optical purification of¹d-p-hydroxyphenylglycineInfo
- Publication number
- IE41879L IE41879L IE752458A IE245875A IE41879L IE 41879 L IE41879 L IE 41879L IE 752458 A IE752458 A IE 752458A IE 245875 A IE245875 A IE 245875A IE 41879 L IE41879 L IE 41879L
- Authority
- IE
- Ireland
- Prior art keywords
- hydroxyphenylglycine
- solution
- of1d
- hbr
- isomer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1476110 Obtaining optically pure D-p-hydroxyphenylglycine PFIZER Inc 20 Nov 1975 [9 Jan 1975] 47870/75 Heading C2C The invention comprises a process for separating D-p-hydroxyphenylglycine from a mixture containing D and DL-p-hydroxyphenylglycine and/or the C 1-10 alkyl esters thereof wherein (a) said mixture is dissolved in aqueous hydrobromic acid (b) insoluble DL-p-hydroxyphenylglycine HBr is separated from the solution, (c) the pH of the solution is adjusted to a value in the range 4À0 to 6À0 and (d) isolating the D- isomer from the solution in crystalline form. The hydrobromide of D-p-hydroxyphenylglycine may be isolated from stage (b) after separation of the DL isomer by, e.g. evaporation of the HBr and then dissolved to form an aqueous solution from which the free amino acid can be obtained by treatment with alkali. When the starting material is or includes C 1-10 alkyl esters these are hydrolysed during the reaction.
[GB1476110A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53971775A | 1975-01-09 | 1975-01-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41879L true IE41879L (en) | 1976-07-09 |
| IE41879B1 IE41879B1 (en) | 1980-04-09 |
Family
ID=24152365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2458/75A IE41879B1 (en) | 1975-01-09 | 1975-11-11 | Process for optical purification of d-p-hydroxyphenylglycine |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5191228A (en) |
| AR (1) | AR205293A1 (en) |
| BE (1) | BE837214A (en) |
| CA (1) | CA1033760A (en) |
| DK (1) | DK146801C (en) |
| ES (1) | ES444002A1 (en) |
| FR (1) | FR2297208A1 (en) |
| GB (1) | GB1476110A (en) |
| IE (1) | IE41879B1 (en) |
| LU (1) | LU74131A1 (en) |
| MX (1) | MX3598E (en) |
| NL (1) | NL7514992A (en) |
| SE (1) | SE7600016L (en) |
-
1975
- 1975-01-01 AR AR261831A patent/AR205293A1/en active
- 1975-11-11 IE IE2458/75A patent/IE41879B1/en unknown
- 1975-11-20 GB GB4787075A patent/GB1476110A/en not_active Expired
- 1975-12-23 NL NL7514992A patent/NL7514992A/en not_active Application Discontinuation
- 1975-12-30 CA CA242,783A patent/CA1033760A/en not_active Expired
- 1975-12-30 DK DK594175A patent/DK146801C/en not_active IP Right Cessation
- 1975-12-31 BE BE1007110A patent/BE837214A/en not_active IP Right Cessation
- 1975-12-31 FR FR7540229A patent/FR2297208A1/en active Granted
- 1975-12-31 ES ES444002A patent/ES444002A1/en not_active Expired
-
1976
- 1976-01-02 LU LU74131A patent/LU74131A1/xx unknown
- 1976-01-02 SE SE7600016A patent/SE7600016L/en unknown
- 1976-01-05 JP JP51000578A patent/JPS5191228A/en active Granted
- 1976-01-06 MX MX761298U patent/MX3598E/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1033760A (en) | 1978-06-27 |
| DK146801B (en) | 1984-01-09 |
| DK594175A (en) | 1976-07-10 |
| NL7514992A (en) | 1976-07-13 |
| DK146801C (en) | 1984-06-18 |
| JPS5191228A (en) | 1976-08-10 |
| JPS5636184B2 (en) | 1981-08-22 |
| FR2297208B1 (en) | 1978-01-27 |
| DE2552932A1 (en) | 1976-07-15 |
| IE41879B1 (en) | 1980-04-09 |
| FR2297208A1 (en) | 1976-08-06 |
| AR205293A1 (en) | 1976-04-21 |
| AU8791775A (en) | 1977-07-07 |
| DE2552932B2 (en) | 1977-07-07 |
| SE7600016L (en) | 1976-07-12 |
| MX3598E (en) | 1981-03-25 |
| LU74131A1 (en) | 1976-11-11 |
| ES444002A1 (en) | 1977-04-16 |
| BE837214A (en) | 1976-06-30 |
| GB1476110A (en) | 1977-06-10 |
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