IE41888L - Cephalosporin derivatives. - Google Patents
Cephalosporin derivatives.Info
- Publication number
- IE41888L IE41888L IE751366A IE136675A IE41888L IE 41888 L IE41888 L IE 41888L IE 751366 A IE751366 A IE 751366A IE 136675 A IE136675 A IE 136675A IE 41888 L IE41888 L IE 41888L
- Authority
- IE
- Ireland
- Prior art keywords
- group
- nitrogen atoms
- acetoxy
- radical
- denotes
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 2
- 150000003839 salts Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- -1 mercapto compound Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000004149 thio group Chemical group *S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Acyl derivatives of the general formula X-S-Y in which X denotes a 3-acetoxymethylcephalosporinyl radical decreased by the acetoxy group and -S-Y denotes the thio group standing instead of the acetoxy group, in which Y represents a 6-membered, optionally substituted, heterocyclic radical having 1 to 3 nitrogen atoms, which is not heteroaromatic and cannot be enolised to give a heteroaromatic radical, where at least one of these nitrogen atoms is substituted and at least one of these nitrogen atoms forms an amide group with an adjacent carbonyl group, or salts of these compounds or hydrates of these salts are antibiotically active products. These products can be prepared by reacting a cephalosporin derivative which carries an easily removable group on the 3-methyl group instead of the acetoxy substituent and whose carboxyl group in position 4 is present in protected form, with a mercapto compound Y-SH and removing the protective group.
[GB1471804A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH853774A CH609989A5 (en) | 1974-06-21 | 1974-06-21 | Process for the preparation of acyl derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE41888L true IE41888L (en) | 1975-12-21 |
| IE41888B1 IE41888B1 (en) | 1980-04-23 |
Family
ID=4341690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1366/75A IE41888B1 (en) | 1974-06-21 | 1975-06-18 | Substituted desacetoxy-7-acylamino-cephalosporanic acids |
Country Status (25)
| Country | Link |
|---|---|
| JP (1) | JPS625917B2 (en) |
| AT (1) | AT337897B (en) |
| AU (1) | AU498387B2 (en) |
| BE (1) | BE830455A (en) |
| BR (1) | BR7503782A (en) |
| CA (1) | CA1111021A (en) |
| CH (1) | CH609989A5 (en) |
| CU (1) | CU34293A (en) |
| DD (1) | DD121113A5 (en) |
| DE (1) | DE2527291A1 (en) |
| DK (2) | DK153155C (en) |
| FI (1) | FI751815A7 (en) |
| FR (1) | FR2275215A1 (en) |
| GB (1) | GB1471804A (en) |
| HU (1) | HU170576B (en) |
| IE (1) | IE41888B1 (en) |
| IL (1) | IL47299A (en) |
| LU (1) | LU72771A1 (en) |
| NL (1) | NL180665C (en) |
| NO (1) | NO752202L (en) |
| NZ (1) | NZ177508A (en) |
| PH (1) | PH13030A (en) |
| SE (1) | SE431755B (en) |
| SU (2) | SU635873A3 (en) |
| ZA (1) | ZA753086B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7805715A (en) * | 1977-06-03 | 1978-12-05 | Hoffmann La Roche | METHOD FOR PREPARING ACYL DERIVATIVES. |
| JPS5419990A (en) * | 1977-07-14 | 1979-02-15 | Shionogi & Co Ltd | Dihydrotriazinylthioxacephalosporin |
| MC1259A1 (en) * | 1978-05-30 | 1980-01-14 | Hoffmann La Roche | ACYL DERIVATIVES |
| FR2474030A1 (en) * | 1980-01-17 | 1981-07-24 | Rhone Poulenc Ind | 2-Mercapto-1,2,4-triazine, 1,3,4-triazole or tetrazole derivs. - useful as intermediates for antibacterial cephalosporin(s) |
| FR2494278A1 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM |
| JP2004538265A (en) * | 2001-04-19 | 2004-12-24 | ビオフェルマ ムルシア，エス．アー． | Method for producing 3-cephalosporanic acid derivative using α-keto acid derivative |
| WO2009109259A1 (en) | 2008-03-05 | 2009-09-11 | Merck Patent Gmbh | Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3868369A (en) * | 1972-11-14 | 1975-02-25 | Smithkline Corp | 3-heterocyclicthiomethylcephalosporins |
-
1974
- 1974-06-21 CH CH853774A patent/CH609989A5/en not_active IP Right Cessation
-
1975
- 1975-05-13 NZ NZ177508A patent/NZ177508A/en unknown
- 1975-05-13 ZA ZA00753086A patent/ZA753086B/en unknown
- 1975-05-14 IL IL47299A patent/IL47299A/en unknown
- 1975-06-06 AU AU81912/75A patent/AU498387B2/en not_active Expired
- 1975-06-16 SE SE7506908A patent/SE431755B/en not_active IP Right Cessation
- 1975-06-17 BR BR4864/75D patent/BR7503782A/en unknown
- 1975-06-17 DK DK271975A patent/DK153155C/en not_active IP Right Cessation
- 1975-06-17 PH PH17273A patent/PH13030A/en unknown
- 1975-06-18 IE IE1366/75A patent/IE41888B1/en unknown
- 1975-06-18 SU SU752145554A patent/SU635873A3/en active
- 1975-06-18 FI FI751815A patent/FI751815A7/fi not_active Application Discontinuation
- 1975-06-18 JP JP50074251A patent/JPS625917B2/ja not_active Expired
- 1975-06-19 DE DE19752527291 patent/DE2527291A1/en active Granted
- 1975-06-19 FR FR7519213A patent/FR2275215A1/en active Granted
- 1975-06-19 LU LU72771A patent/LU72771A1/xx unknown
- 1975-06-20 BE BE157517A patent/BE830455A/en not_active IP Right Cessation
- 1975-06-20 NO NO752202A patent/NO752202L/no unknown
- 1975-06-20 CU CU7534293A patent/CU34293A/en unknown
- 1975-06-20 AT AT476975A patent/AT337897B/en not_active IP Right Cessation
- 1975-06-20 GB GB2634175A patent/GB1471804A/en not_active Expired
- 1975-06-20 HU HUHO1808A patent/HU170576B/hu unknown
- 1975-06-20 DD DD186797A patent/DD121113A5/xx unknown
- 1975-06-20 NL NLAANVRAGE7507390,A patent/NL180665C/en not_active IP Right Cessation
- 1975-06-20 CA CA229,803A patent/CA1111021A/en not_active Expired
-
1976
- 1976-01-07 SU SU762309104A patent/SU589921A3/en active
-
1987
- 1987-08-28 DK DK453687A patent/DK155329C/en not_active IP Right Cessation
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