IE42395L - Long-acting insulin preparations - Google Patents
Long-acting insulin preparationsInfo
- Publication number
- IE42395L IE42395L IE760062A IE6276A IE42395L IE 42395 L IE42395 L IE 42395L IE 760062 A IE760062 A IE 760062A IE 6276 A IE6276 A IE 6276A IE 42395 L IE42395 L IE 42395L
- Authority
- IE
- Ireland
- Prior art keywords
- protein
- basic
- long
- acting insulin
- dissociating
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 102000016261 Long-Acting Insulin Human genes 0.000 title 1
- 108010092217 Long-Acting Insulin Proteins 0.000 title 1
- 229940100066 Long-acting insulin Drugs 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 150000002894 organic compounds Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000007327 Protamines Human genes 0.000 abstract 1
- 108010007568 Protamines Proteins 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000012062 aqueous buffer Substances 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000002045 lasting effect Effects 0.000 abstract 1
- 229940070353 protamines Drugs 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
A stable insulin preparation having a lasting action and having low antigenicity is prepared by reaction of acidic groups of the insulin with basic groups of organic compounds. The reaction is carried out in an aqueous buffer solution which contains a protein-dissociating or protein-depolymerising agent. Basic polypeptides, e.g. protamines, or cleavage products of basic polypeptides are preferred as organic compounds containing a basic group. The protein-dissociating or protein-depolymerising agent is preferably urea.
[GB1524431A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK8375AA DK140801B (en) | 1975-01-15 | 1975-01-15 | Process for the preparation of a stable long-acting insulin preparation. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42395L true IE42395L (en) | 1976-07-15 |
| IE42395B1 IE42395B1 (en) | 1980-07-30 |
Family
ID=8089535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE62/76A IE42395B1 (en) | 1975-01-15 | 1976-01-13 | Production of long acting insulin preparations |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5946939B2 (en) |
| AR (1) | AR213088A1 (en) |
| AT (1) | AT362492B (en) |
| BE (1) | BE837600A (en) |
| BR (1) | BR7600206A (en) |
| CA (1) | CA1094549A (en) |
| CH (1) | CH631625A5 (en) |
| CS (1) | CS208147B2 (en) |
| DD (1) | DD124379A5 (en) |
| DE (1) | DE2600971C2 (en) |
| DK (1) | DK140801B (en) |
| EG (1) | EG11988A (en) |
| ES (1) | ES444558A1 (en) |
| FI (1) | FI66751C (en) |
| FR (1) | FR2297634A1 (en) |
| GB (1) | GB1524431A (en) |
| GR (1) | GR58608B (en) |
| HU (1) | HU175142B (en) |
| IE (1) | IE42395B1 (en) |
| IL (1) | IL48845A (en) |
| IN (1) | IN143279B (en) |
| IT (1) | IT1054211B (en) |
| KE (1) | KE2919A (en) |
| LU (1) | LU74175A1 (en) |
| MX (1) | MX4052E (en) |
| MY (1) | MY7900169A (en) |
| NL (1) | NL166464C (en) |
| NO (1) | NO146698C (en) |
| NZ (1) | NZ179733A (en) |
| OA (1) | OA05209A (en) |
| PL (1) | PL99927B1 (en) |
| PT (1) | PT64696B (en) |
| RO (1) | RO71576A (en) |
| SE (1) | SE437219B (en) |
| YU (1) | YU8376A (en) |
| ZA (1) | ZA7658B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK374579A (en) * | 1979-09-07 | 1981-03-08 | Nordisk Insulinlab | PROCEDURE FOR THE PREPARATION OF AN INJUCABLE INSULIN PREPARATION |
| US4459226A (en) * | 1982-02-26 | 1984-07-10 | Eli Lilly And Company | Process for recovering insulin |
| US4801575A (en) * | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4878892A (en) * | 1987-02-10 | 1989-11-07 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of polypeptides |
| AU609769B2 (en) * | 1987-02-10 | 1991-05-09 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of proteins |
| US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5447728A (en) | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
| US6051258A (en) | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| EP2414560B1 (en) | 2009-03-31 | 2013-10-23 | Boehringer Ingelheim International GmbH | Method for coating a surface of a component |
| EP3508239B1 (en) | 2009-05-18 | 2020-12-23 | Boehringer Ingelheim International GmbH | Adapter, inhalant apparatus and atomizer |
| JP5658268B2 (en) | 2009-11-25 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Nebulizer |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| MX2012005961A (en) | 2009-11-25 | 2012-06-14 | Boehringer Ingelheim Int | Nebulizer. |
| JP5874724B2 (en) | 2010-06-24 | 2016-03-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Nebulizer |
| WO2012130757A1 (en) | 2011-04-01 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Medical device comprising a container |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2013152894A1 (en) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Atomiser with coding means |
| EP2835146B1 (en) | 2013-08-09 | 2020-09-30 | Boehringer Ingelheim International GmbH | Nebulizer |
| WO2015018904A1 (en) | 2013-08-09 | 2015-02-12 | Boehringer Ingelheim International Gmbh | Nebulizer |
| MX383195B (en) | 2014-05-07 | 2025-03-13 | Boehringer Ingelheim Int | CONTAINER, NEBULIZER AND USE. |
| BR122022010094B1 (en) | 2014-05-07 | 2023-10-03 | Boehringer Ingelheim International Gmbh | INDICATING DEVICE AND CONTAINER |
| WO2015169430A1 (en) | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Nebulizer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1285023A (en) * | 1968-08-09 | 1972-08-09 | Novo Terapeutisk Labor As | Improvements in or relating to injectable insulin preparations |
| US3758683A (en) * | 1971-04-30 | 1973-09-11 | R Jackson | Insulin product |
-
1975
- 1975-01-15 DK DK8375AA patent/DK140801B/en not_active IP Right Cessation
-
1976
- 1976-01-06 ZA ZA00760058A patent/ZA7658B/en unknown
- 1976-01-07 IN IN41/CAL/76A patent/IN143279B/en unknown
- 1976-01-07 GR GR49734A patent/GR58608B/en unknown
- 1976-01-12 NZ NZ179733A patent/NZ179733A/en unknown
- 1976-01-12 FI FI760058A patent/FI66751C/en not_active IP Right Cessation
- 1976-01-12 CA CA243,587A patent/CA1094549A/en not_active Expired
- 1976-01-13 IE IE62/76A patent/IE42395B1/en unknown
- 1976-01-13 IT IT19221/76A patent/IT1054211B/en active
- 1976-01-13 LU LU74175A patent/LU74175A1/xx unknown
- 1976-01-13 DE DE2600971A patent/DE2600971C2/en not_active Expired
- 1976-01-13 SE SE7600284A patent/SE437219B/en not_active IP Right Cessation
- 1976-01-14 FR FR7600854A patent/FR2297634A1/en active Granted
- 1976-01-14 PL PL1976186526A patent/PL99927B1/en unknown
- 1976-01-14 NL NL7600338.A patent/NL166464C/en not_active IP Right Cessation
- 1976-01-14 BR BR7600206A patent/BR7600206A/en unknown
- 1976-01-14 RO RO7684491A patent/RO71576A/en unknown
- 1976-01-14 GB GB1309/76A patent/GB1524431A/en not_active Expired
- 1976-01-14 DD DD190805A patent/DD124379A5/xx unknown
- 1976-01-14 OA OA55703A patent/OA05209A/en unknown
- 1976-01-14 YU YU00083/76A patent/YU8376A/en unknown
- 1976-01-14 NO NO760118A patent/NO146698C/en unknown
- 1976-01-14 AT AT21376A patent/AT362492B/en not_active IP Right Cessation
- 1976-01-14 PT PT64696A patent/PT64696B/en unknown
- 1976-01-14 MX MX764822U patent/MX4052E/en unknown
- 1976-01-15 ES ES444558A patent/ES444558A1/en not_active Expired
- 1976-01-15 CS CS76270A patent/CS208147B2/en unknown
- 1976-01-15 IL IL48845A patent/IL48845A/en unknown
- 1976-01-15 BE BE163542A patent/BE837600A/en not_active IP Right Cessation
- 1976-01-15 CH CH47076A patent/CH631625A5/en not_active IP Right Cessation
- 1976-01-15 HU HU76NO198A patent/HU175142B/en unknown
- 1976-01-16 JP JP51003293A patent/JPS5946939B2/en not_active Expired
- 1976-01-17 EG EG16/76A patent/EG11988A/en active
-
1978
- 1978-01-14 AR AR261924A patent/AR213088A1/en active
-
1979
- 1979-02-07 KE KE2919A patent/KE2919A/en unknown
- 1979-12-30 MY MY169/79A patent/MY7900169A/en unknown
Also Published As
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