IE42425L - Aryloxy and arylthio-alkanoates having cholesterol-reducing¹properties. - Google Patents
Aryloxy and arylthio-alkanoates having cholesterol-reducing¹properties.Info
- Publication number
- IE42425L IE42425L IE742658A IE265874A IE42425L IE 42425 L IE42425 L IE 42425L IE 742658 A IE742658 A IE 742658A IE 265874 A IE265874 A IE 265874A IE 42425 L IE42425 L IE 42425L
- Authority
- IE
- Ireland
- Prior art keywords
- group
- hydrogen
- carbon atoms
- alkoxycarbonyl
- alkyl
- Prior art date
Links
- 125000004104 aryloxy group Chemical group 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 benzylthio group Chemical group 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 abstract 1
- 101100188552 Arabidopsis thaliana OCT3 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000003312 cholesterol blood level Effects 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Testing Resistance To Weather, Investigating Materials By Mechanical Methods (AREA)
Abstract
1497266 Aryl-oxy- and -thio-alkyl compounds SIEGFRIED AG 24 Dec 1974 [27 Dec 1973 (2) 28 March 1974 3 Oct 1974 18 Nov 1974 (2)] 55755/74 Heading C2C The invention comprises novel compounds (I) wherein: R represents hydrogen, halogen, hydroxy; or alkyl or alkoxy containing from 1 to 4 carbon atoms; X represents hydrogen or a benzyl, benzyloxy or benzylthio group which is optionally substituted by a said group R; Y represents a sulphur or oxygen atom; Z represents a carboxyl group, an alkoxycarbonyl group, a cycloalkoxycarbonyl group, a carbamoyl group, an esterified carboxyl group in which the esterifying group contains an amino group, or a pivaloyloxymethoxy carbonyl group; and A<SP>1</SP> and A<SP>2</SP> which can be the same or different are hydrogen atoms or alkyl groups containing from 1 to 4 carbon atoms, and pharmacologically acceptable salts thereof with inorganic or organic acids or bases if they contain basic or acidic groups respectively and/ or optical isomers thereof, when A<SP>1</SP> and A<SP>2</SP> are different, with the proviso that, when Z represents a free carboxyl group or an alkoxycarbonyl group, either X represents benzyl, benzyloxy or benzylmercapto substituted by a halogen or X represents benzyl, benzyloxy or benzylmercapto and A<SP>1</SP> and A<SP>2</SP> together contain at least 3 carbon atoms, and with the proviso that when R is hydrogen, X is p-chlorobenzyl, Y is oxygen, Z is hydrogen, alkoxycarbonyl or dialkyl amino-alkoxycarbonyl, A<SP>1</SP> and A<SP>2</SP> are the same or different and are alkyl groups containing from 2 to 4 carbon atoms or hydrogen or one of A<SP>1</SP> and A<SP>2</SP> is methyl and the other is hydrogen or an alkyl group containing from 2 to 4 carbon atoms. The compounds are made by standard methods. Pharmaceutical preparations effective in lowering the cholesterol blood level contain (I) as active ingredient. Administration is orally or parenterally.
[GB1497266A]
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1814473A CH605557A5 (en) | 1973-12-27 | 1973-12-27 | Phenoxy- and phenylthio-alkanes |
| CH1814573A CH601169A5 (en) | 1973-12-27 | 1973-12-27 | Phenoxy- and phenylthio-alkanes |
| CH435574A CH605642A5 (en) | 1974-03-28 | 1974-03-28 | Phenoxy- and phenylthio-alkanes |
| CH1330274A CH616909A5 (en) | 1974-10-03 | 1974-10-03 | Process for the preparation of aromatically substituted olefins |
| CH1532974A CH617417A5 (en) | 1973-12-27 | 1974-11-18 | |
| CH1533074A CH617420A5 (en) | 1974-11-18 | 1974-11-18 | Process for the preparation of novel pivaloyloxymethyl esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42425L true IE42425L (en) | 1975-06-27 |
| IE42425B1 IE42425B1 (en) | 1980-08-13 |
Family
ID=27543738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2658/74A IE42425B1 (en) | 1973-12-27 | 1974-12-23 | Aryloxy-and arythio-alkanoates having cholesterol-reducing properties |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5934695B2 (en) |
| BE (1) | BE823904A (en) |
| DE (2) | DE2463001C2 (en) |
| DK (1) | DK157005C (en) |
| FR (1) | FR2255891B1 (en) |
| GB (1) | GB1497266A (en) |
| IE (1) | IE42425B1 (en) |
| LU (1) | LU71561A1 (en) |
| NL (1) | NL7416412A (en) |
| SE (1) | SE426582B (en) |
| SU (1) | SU612619A3 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4211551A (en) * | 1976-11-15 | 1980-07-08 | Siegfried Ag | Herbicide |
| US4214095A (en) * | 1979-01-25 | 1980-07-22 | Siegfried Aktiengesellschaft | Chlorobenzyl phenoxy alkoxylates |
| FR2481702A1 (en) * | 1980-04-30 | 1981-11-06 | Anvar | CYCLIC AMINOUS SUBSTITUTED PHENOXYACETATES, PROCESS FOR OBTAINING THE SAME, APPLICATIONS AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
| DE3037391A1 (en) * | 1980-10-03 | 1982-05-19 | King Consult GmbH, 5000 Köln | ESTERS OF 7-HYDROXYALKYL-1,3-DIMETHYLXANTHINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A LIPID-REDUCING AGENT |
| EP0059974B1 (en) * | 1981-03-11 | 1985-07-31 | Ludwig Merckle GmbH & Co. chem.-pharm. Fabrik | Process for the preparation of phenoxyalcanecarbonic-acid esters of hydroxyethyl theophyline |
| JPS59172440A (en) * | 1983-03-23 | 1984-09-29 | Nippon Tokushu Noyaku Seizo Kk | Substituted phenoxypropionic ester, its intermediate, its preparation, and herbicide |
| JPH02502998A (en) * | 1988-01-22 | 1990-09-20 | ハルコフスキ ナウチノ‐イススレドバテルスキ インスティテュト エンドクリノロギイ イ ヒミイ ゴルモノフ | n-chlorophenoxyisobutyric acid undecyl ester and pharmaceutical preparations based on the same for the treatment of hyperlipidemia |
| DE102011006425A1 (en) | 2010-03-31 | 2011-10-06 | Awd.Pharma Gmbh & Co. Kg | Pharmaceutical composition, useful for treating and/or preventing e.g. Parkinson's disease, dementia, neuropathic pain, retinitis pigmentosa, multiple sclerosis and amyotrophic lateral sclerosis, comprises flupirtine and N-acetylcysteine |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB860303A (en) * | 1958-06-20 | 1961-02-01 | Ici Ltd | Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª |
| GB1064252A (en) * | 1963-09-19 | 1967-04-05 | Ici Ltd | Amides and pharmaceutical compositions containing them |
| FR1498459A (en) | 1965-07-30 | 1968-01-08 | ||
| GB1121722A (en) * | 1966-03-31 | 1968-07-31 | Ici Ltd | New carboxylic acid derivatives |
| GB1140748A (en) * | 1966-06-23 | 1969-01-22 | Ici Ltd | New carboxylic acid derivatives |
| DE2149070C3 (en) * | 1971-10-01 | 1978-03-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Phenoxyalkylcarboxylic acid derivatives and their salts, processes for their production and pharmaceuticals |
| GB1422679A (en) * | 1972-11-16 | 1976-01-28 | Funai Pharmaceutical Ind Ltd | Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same |
| DE2308826C3 (en) * | 1973-02-22 | 1980-03-27 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | Phenoxyalkanecarboxylic acid esters of oxyalkyl theophyllines, process for their preparation and pharmaceuticals |
-
1974
- 1974-12-17 NL NL7416412A patent/NL7416412A/en not_active Application Discontinuation
- 1974-12-20 SE SE7416163A patent/SE426582B/en not_active IP Right Cessation
- 1974-12-20 DK DK670274A patent/DK157005C/en not_active IP Right Cessation
- 1974-12-23 IE IE2658/74A patent/IE42425B1/en unknown
- 1974-12-23 DE DE2463001A patent/DE2463001C2/de not_active Expired
- 1974-12-23 DE DE2461069A patent/DE2461069C3/en not_active Expired
- 1974-12-24 LU LU71561A patent/LU71561A1/xx unknown
- 1974-12-24 GB GB55755/74A patent/GB1497266A/en not_active Expired
- 1974-12-25 SU SU742090104A patent/SU612619A3/en active
- 1974-12-27 FR FR7443033A patent/FR2255891B1/fr not_active Expired
- 1974-12-27 BE BE151969A patent/BE823904A/en not_active IP Right Cessation
- 1974-12-27 JP JP49149036A patent/JPS5934695B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE42425B1 (en) | 1980-08-13 |
| SE426582B (en) | 1983-01-31 |
| BE823904A (en) | 1975-06-27 |
| DK157005C (en) | 1990-03-26 |
| DE2463001C2 (en) | 1988-11-24 |
| AU7690274A (en) | 1976-07-01 |
| FR2255891B1 (en) | 1978-11-10 |
| SU612619A3 (en) | 1978-06-25 |
| JPS5934695B2 (en) | 1984-08-24 |
| JPS50105621A (en) | 1975-08-20 |
| DE2461069B2 (en) | 1980-10-02 |
| DE2461069A1 (en) | 1975-07-17 |
| DE2461069C3 (en) | 1981-07-23 |
| GB1497266A (en) | 1978-01-05 |
| FR2255891A1 (en) | 1975-07-25 |
| DK157005B (en) | 1989-10-30 |
| DK670274A (en) | 1975-09-08 |
| SE7416163L (en) | 1975-06-30 |
| NL7416412A (en) | 1975-07-01 |
| LU71561A1 (en) | 1975-08-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1432576A (en) | Substituted phenylacetic acids | |
| KR960000230A (en) | Hepatobiliary Disease Drug | |
| KR920018011A (en) | N-acyl-α-amino acid derivatives | |
| IE36947L (en) | 14 - dihydropyridinecarboxycic acid esters | |
| IE42425L (en) | Aryloxy and arylthio-alkanoates having cholesterol-reducing¹properties. | |
| GB1342520A (en) | Alpha-alkyl-substituted benzyl or thenyl-benzyloxy derivatives of amines | |
| GB1355147A (en) | Oxoprostanoic acid derivatives | |
| IE34314B1 (en) | Dibenzodioxocine derivatives | |
| GB1496491A (en) | Dihydroergopeptine derivatives | |
| GB1225462A (en) | ||
| GB1504426A (en) | Clavulanic acid derivatives | |
| GB1299201A (en) | Medicaments derived from thiazolidine carboxylic acid | |
| KR890701584A (en) | Novel Substituted Derivatives of 20,21-Dinoerbinenamenin, Methods for Making and Novel Intermediates Obtained by the Methods, Their Use as Pharmaceuticals and Pharmaceutical Compositions Containing the Same | |
| GB1353832A (en) | Sulphonium compounds of alpha-hydroxy-gamma-alkyl-mercapto butyric acid | |
| KR890007752A (en) | Vincristine-containing product | |
| GB1346554A (en) | Derivatives of thienyl-3,-acetic acid and processes for their preparation | |
| KR880013896A (en) | Benzofuro [3,2-C] quinoline compound | |
| SE7414606L (en) | ||
| AU544236B2 (en) | Amidines | |
| GB1504683A (en) | Pharmaceutical compositions containing substituted pyrimido-quinoline derivatives | |
| IE33346B1 (en) | Cyclohexa-1,4-diene-1-acetic acids | |
| GB1417817A (en) | Substituted acetic acid cyclohexyl esters the preparation thereof and pharmaceutical compositions containing them | |
| KR890009876A (en) | Memory promoter comprising 9-acylamino-tetrahydroacridine derivatives and derivatives thereof as active ingredient | |
| GB1444870A (en) | Pyrazoline derivatives | |
| ES481492A1 (en) | Substituted amino acids, their use and preparation and pharmaceutical compositions containing them. |