IE42439L - Tertiaryaminopropanols - Google Patents
TertiaryaminopropanolsInfo
- Publication number
- IE42439L IE42439L IE751613A IE161375A IE42439L IE 42439 L IE42439 L IE 42439L IE 751613 A IE751613 A IE 751613A IE 161375 A IE161375 A IE 161375A IE 42439 L IE42439 L IE 42439L
- Authority
- IE
- Ireland
- Prior art keywords
- opt
- branched alkyl
- cpds
- sulphanmoyl
- saluretics
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000029142 excretion Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 230000000894 saliuretic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Cpds of formula (I) and their salts: (where R'1, R" are 1-6C opt. branched alkyl or together with the N atom form a 5- or 6-membered ring R1-R10 are each H, 1-6C opt. branched alkyl, 2-3C alkenyl, hydroxy, 1-4C alkoxy (2 adjacent gps together may form a 5 or 6-membered heterocyclic ring withone or two heteroatoms), benzyloxy or halo) are diuretics and saluretics which cause less potassium excretion than known cpds. Pharmacological tests comparing their activity with 2,4,7-triamino-6-phenyl pteridine and 6-chloro-3,4-dihydro,7-sulphanmoyl-2H-1,2,4-benzothiadiazine-1,1-- dioxide. (I) may be administered orally or parenterally with the usual vehicles.
[DE2508203A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2508203A DE2508203C2 (en) | 1975-02-26 | 1975-02-26 | Use of polysubstituted α, α-diphenyl-β- (tert-amino) propanols in saluretic therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42439L true IE42439L (en) | 1976-08-26 |
| IE42439B1 IE42439B1 (en) | 1980-08-13 |
Family
ID=5939810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1613/75A IE42439B1 (en) | 1975-02-26 | 1975-07-18 | , -diaryl- -(tert-amino)-propanols, processes for their preparation and pharmaceutical compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| CS (1) | CS194723B2 (en) |
| DE (1) | DE2508203C2 (en) |
| EG (1) | EG12529A (en) |
| FI (1) | FI752082A7 (en) |
| HU (1) | HU171369B (en) |
| IE (1) | IE42439B1 (en) |
| LU (1) | LU72953A1 (en) |
| MX (1) | MX3548E (en) |
| NO (1) | NO142908C (en) |
| NZ (1) | NZ178112A (en) |
| PL (1) | PL101806B1 (en) |
| RO (1) | RO70352A (en) |
| SU (2) | SU618035A3 (en) |
| YU (1) | YU182575A (en) |
-
1975
- 1975-02-26 DE DE2508203A patent/DE2508203C2/en not_active Expired
- 1975-06-17 YU YU01825/75A patent/YU182575A/en unknown
- 1975-07-10 LU LU72953A patent/LU72953A1/xx unknown
- 1975-07-10 NO NO752485A patent/NO142908C/en unknown
- 1975-07-11 HU HU75TE00000831A patent/HU171369B/en unknown
- 1975-07-15 NZ NZ178112A patent/NZ178112A/en unknown
- 1975-07-18 FI FI752082A patent/FI752082A7/fi not_active Application Discontinuation
- 1975-07-18 IE IE1613/75A patent/IE42439B1/en unknown
- 1975-07-21 RO RO7582915A patent/RO70352A/en unknown
- 1975-07-21 CS CS755150A patent/CS194723B2/en unknown
- 1975-07-22 SU SU752159077A patent/SU618035A3/en active
- 1975-07-28 MX MX75100032U patent/MX3548E/en unknown
- 1975-08-13 PL PL1975182711A patent/PL101806B1/en unknown
-
1976
- 1976-02-25 EG EG111/76A patent/EG12529A/en active
- 1976-05-11 SU SU762355956A patent/SU614093A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| LU72953A1 (en) | 1976-02-04 |
| PL101806B1 (en) | 1979-02-28 |
| MX3548E (en) | 1981-02-19 |
| YU182575A (en) | 1982-02-28 |
| RO70352A (en) | 1982-02-26 |
| IE42439B1 (en) | 1980-08-13 |
| DE2508203A1 (en) | 1976-09-09 |
| EG12529A (en) | 1979-12-31 |
| FI752082A7 (en) | 1976-08-27 |
| DE2508203C2 (en) | 1984-03-01 |
| NO752485L (en) | 1976-08-27 |
| SU614093A1 (en) | 1978-07-05 |
| NO142908B (en) | 1980-08-04 |
| SU618035A3 (en) | 1978-07-30 |
| HU171369B (en) | 1977-12-28 |
| CS194723B2 (en) | 1979-12-31 |
| NO142908C (en) | 1980-11-12 |
| NZ178112A (en) | 1978-04-28 |
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