IE42452L - Aminoglycosides - Google Patents
AminoglycosidesInfo
- Publication number
- IE42452L IE42452L IE752316A IE231675A IE42452L IE 42452 L IE42452 L IE 42452L IE 752316 A IE752316 A IE 752316A IE 231675 A IE231675 A IE 231675A IE 42452 L IE42452 L IE 42452L
- Authority
- IE
- Ireland
- Prior art keywords
- kanamycin
- hydroxybutyl
- oct
- amino
- hours
- Prior art date
Links
- 229940126575 aminoglycoside Drugs 0.000 title abstract 2
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 abstract 2
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 abstract 2
- OCFOTEIMZBKQFS-DGMGPCKZSA-N (2r,3r,4s,5s,6r)-2-[(1r,2s,3s,4r,6s)-6-amino-3-[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[[(2s)-4-amino-2-hydroxybutyl]amino]-2-hydroxycyclohexyl]oxy-6-(aminomethyl)oxane-3,4,5-triol Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O OCFOTEIMZBKQFS-DGMGPCKZSA-N 0.000 abstract 1
- 229960000318 kanamycin Drugs 0.000 abstract 1
- 229930182823 kanamycin A Natural products 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000005051 trimethylchlorosilane Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1464401 Silylated aminoglycoside PFIZER Ltd 24 Oct 1975 [26 Oct 1974] 46412/74 Heading C3S [Also in Division C2] The penta - N - acetyl - octa - O - trimethylsilyl derivative of 1 - N - [(S) - 4 - amino - 2- hydroxybutyl] - kanamycin A is prepared by treating 1 - N - [(S) - 4 - amino - 2 - hydroxybutyl]-kanamycin A with acetic anhydride in methanol at room temperature for 24 hours, followed by a 2 : 1 mixture of hexamethyldisilazane and trimethylchlorosilane at room temperature for 24 hours.
[GB1464401A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4641274A GB1464401A (en) | 1974-10-26 | 1974-10-26 | Aminoglycosides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42452L true IE42452L (en) | 1976-04-26 |
| IE42452B1 IE42452B1 (en) | 1980-08-13 |
Family
ID=10441164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2316/75A IE42452B1 (en) | 1974-10-26 | 1975-10-24 | Aminoglycosides |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS5519237B2 (en) |
| AR (1) | AR205593A1 (en) |
| AT (1) | AT340051B (en) |
| BE (1) | BE834864A (en) |
| BG (1) | BG24821A3 (en) |
| CA (1) | CA1039275A (en) |
| CH (1) | CH601339A5 (en) |
| CS (1) | CS195712B2 (en) |
| DD (1) | DD122522A5 (en) |
| DE (1) | DE2547738C3 (en) |
| DK (1) | DK147075C (en) |
| EG (1) | EG11975A (en) |
| ES (1) | ES442051A1 (en) |
| FI (1) | FI752951A7 (en) |
| FR (1) | FR2289202A1 (en) |
| GB (1) | GB1464401A (en) |
| HU (1) | HU172060B (en) |
| IE (1) | IE42452B1 (en) |
| IL (1) | IL48263A (en) |
| LU (1) | LU73644A1 (en) |
| NL (1) | NL162081C (en) |
| NZ (1) | NZ179050A (en) |
| PH (1) | PH12782A (en) |
| PL (1) | PL99933B1 (en) |
| RO (1) | RO72878A (en) |
| SE (1) | SE7511945L (en) |
| SU (1) | SU617017A3 (en) |
| ZA (1) | ZA756326B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0000473B1 (en) * | 1977-06-24 | 1981-03-11 | Scherico Ltd. | Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives |
| JPS5488241A (en) * | 1977-12-21 | 1979-07-13 | Kyowa Hakko Kogyo Co Ltd | Novel fortimicin a derivative |
| JPS57118475U (en) * | 1981-01-14 | 1982-07-22 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH606076A5 (en) * | 1973-08-06 | 1978-10-13 | Scherico Ltd |
-
1974
- 1974-10-26 GB GB4641274A patent/GB1464401A/en not_active Expired
-
1975
- 1975-01-01 AR AR260909A patent/AR205593A1/en active
- 1975-10-06 ZA ZA00756326A patent/ZA756326B/en unknown
- 1975-10-07 IL IL48263A patent/IL48263A/en unknown
- 1975-10-16 PH PH17665A patent/PH12782A/en unknown
- 1975-10-22 RO RO7583664A patent/RO72878A/en unknown
- 1975-10-22 EG EG627/75A patent/EG11975A/en active
- 1975-10-22 FI FI752951A patent/FI752951A7/fi not_active Application Discontinuation
- 1975-10-23 AT AT809575A patent/AT340051B/en not_active IP Right Cessation
- 1975-10-23 CS CS757161A patent/CS195712B2/en unknown
- 1975-10-24 JP JP12823775A patent/JPS5519237B2/ja not_active Expired
- 1975-10-24 CA CA238,246A patent/CA1039275A/en not_active Expired
- 1975-10-24 HU HU75PI00000496A patent/HU172060B/en unknown
- 1975-10-24 NZ NZ179050A patent/NZ179050A/en unknown
- 1975-10-24 LU LU73644A patent/LU73644A1/xx unknown
- 1975-10-24 ES ES442051A patent/ES442051A1/en not_active Expired
- 1975-10-24 DD DD189046A patent/DD122522A5/xx unknown
- 1975-10-24 DK DK481175A patent/DK147075C/en active
- 1975-10-24 CH CH1380675A patent/CH601339A5/xx not_active IP Right Cessation
- 1975-10-24 PL PL1975184233A patent/PL99933B1/en unknown
- 1975-10-24 SE SE7511945A patent/SE7511945L/en unknown
- 1975-10-24 IE IE2316/75A patent/IE42452B1/en unknown
- 1975-10-24 NL NL7512465.A patent/NL162081C/en not_active IP Right Cessation
- 1975-10-24 SU SU752184101A patent/SU617017A3/en active
- 1975-10-24 BG BG031312A patent/BG24821A3/en unknown
- 1975-10-24 FR FR7532662A patent/FR2289202A1/en active Granted
- 1975-10-24 BE BE161248A patent/BE834864A/en not_active IP Right Cessation
- 1975-10-24 DE DE2547738A patent/DE2547738C3/en not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU470945B2 (en) | Turbocharger compressor with dual collector chambers | |
| CA1022853A (en) | Aerodynamic contrivance for improving the high speed running conditions of motor-cycles | |
| CA964537A (en) | Air intake silencer | |
| AU501185B2 (en) | Exhaust port liner | |
| IE39537B1 (en) | Substituted 16,17,18,19,20-pentanor-prostaglandins | |
| AU494783B2 (en) | Improvements relating to screws | |
| AU1322376A (en) | Controlling supercharged i. c. engine | |
| CA1021212A (en) | Carburetor cold enrichment control | |
| AU465855B2 (en) | Improvements relating to ventilators | |
| IE42452L (en) | Aminoglycosides | |
| AU501559B2 (en) | I. c. engine with exhaust port liner | |
| CA1036027A (en) | Control system of carburetor's choke valves | |
| CA981611A (en) | Enzyme thrombolitique et sa preparation par fermentation de streptomyces venetus | |
| CA1032043A (en) | Carburetor high speed air bleed | |
| CA1016027A (en) | Carburetor temperature responsive throttle plate positioner | |
| CA1011614A (en) | Variable venturi carburetor | |
| AU484106B2 (en) | Carburetor cold enrichment control | |
| CA978434A (en) | Carburetor air bleed engine anti-dieseling control | |
| AU487785B2 (en) | Improvements relating to ventilators | |
| AU488243B2 (en) | Improvements relating to ventilators | |
| CA876175A (en) | Stabilized terpolymer rubber composition | |
| AU496561B2 (en) | Substituted ethenylphenoxy-2, 2-dimethyl acetic acid derivatives | |
| AU492042B2 (en) | Improving carburation | |
| AU490256B2 (en) | Control system of carburetors choke valves | |
| AU7761775A (en) | Improvements relating to ventilators |