IE42609L - Diaryl compounds containing sulphur and/or oxygen. - Google Patents
Diaryl compounds containing sulphur and/or oxygen.Info
- Publication number
- IE42609L IE42609L IE207075A IE207075A IE42609L IE 42609 L IE42609 L IE 42609L IE 207075 A IE207075 A IE 207075A IE 207075 A IE207075 A IE 207075A IE 42609 L IE42609 L IE 42609L
- Authority
- IE
- Ireland
- Prior art keywords
- opt
- oxygen
- compounds containing
- branched
- hydrocarbon
- Prior art date
Links
- 229910052760 oxygen Inorganic materials 0.000 title abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- 239000005864 Sulphur Substances 0.000 title 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title 1
- YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical group C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 title 1
- 239000001301 oxygen Substances 0.000 title 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 150000002430 hydrocarbons Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 abstract 1
- LTYMSROWYAPPGB-UHFFFAOYSA-N diphenyl sulfide Chemical class C=1C=CC=CC=1SC1=CC=CC=C1 LTYMSROWYAPPGB-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 101150009274 nhr-1 gene Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
- C07C43/295—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Diphenyl ethers and diphenylthioethers of gen. formula (I): (in which one of A and B is O,S,SO or So2 and the other is O; Alk is opt. branched 1-4C hydrocarbon; R is opt. esterified carboxyl, amido derived from COOH, OH, -OSO2CH3, NH2, NHR1, NR1R2, NHZOH, NHZNR1R2, C(=NH)NH2, C(NH)NH-OH or 2-delta2-imidazolinyl; Z is opt. branched 2-4C hydrocarbon; R1 and R2 are 1-3C alkyl; R1+R2+N may form a 5-7 membered N-heterocyclic gp. opt. contg. O or N and opt. substd.) and their basic- and acid-addn. salts, may be used in the treatment of circulatory disorders esp. diseases of heart and vessels. Some of (I) lower lipid and/or cholesterol content of the blood, others prevent platelet aggregation. Some of (I) possess all these props.
[DE2543179A1]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4238774A GB1519147A (en) | 1974-09-30 | 1974-09-30 | Sulphur and oxygen-containing diaryl compounds |
| GB158775 | 1975-01-14 | ||
| FR7502307A FR2258846A1 (en) | 1974-01-25 | 1975-01-24 | Bis((N-hydroxy alkyl)-amino alkyl thio)alkane and derivs - as agents preventing blood platelet aggregation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42609L true IE42609L (en) | 1976-03-30 |
| IE42609B1 IE42609B1 (en) | 1980-09-10 |
Family
ID=27250408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE207075A IE42609B1 (en) | 1974-09-30 | 1975-09-22 | Sulphur- and oxygen-containing diaryl compounds |
Country Status (6)
| Country | Link |
|---|---|
| CA (1) | CA1064504A (en) |
| CH (1) | CH609024A5 (en) |
| DE (2) | DE2543179A1 (en) |
| DK (1) | DK146336C (en) |
| IE (1) | IE42609B1 (en) |
| NL (1) | NL176776C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1571829A (en) | 1976-04-06 | 1980-07-23 | Lafon Labor | Sulphur-containing diaryl compounds and oxygen-containing diaryl compounds |
| DE69314718T2 (en) * | 1992-07-21 | 1998-02-26 | Ciba Geigy Ag | Oxamic acid derivatives as hypocholesteremic agents |
| KR100767508B1 (en) | 1999-11-01 | 2007-10-17 | 다이쇼 세이야꾸 가부시끼가이샤 | 20-HＥＴＥ Production Enzyme Inhibitor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1935344U (en) | 1965-11-09 | 1966-03-24 | Karosserie Migoe Chr H Mittelg | DOUBLE WALL FOR VEHICLE BODIES, ESPECIALLY FOR REFRIGERATION AND THERMAL CARRIAGE OD. THE EQUAL, WHERE THE SPACE BETWEEN TWO WALLS IS FILLED WITH INSULATING MATERIAL. |
| DE1668896C3 (en) | 1968-01-11 | 1974-08-29 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Phenoxyalkanecarboxylic acids, their salts and esters, and processes for the preparation of these compounds |
| US3721703A (en) * | 1968-01-11 | 1973-03-20 | Hoechst Ag | Phenoxyalkane-carboxylic acids,salts and esters thereof |
| BE786644A (en) * | 1971-07-23 | 1973-01-24 | Hoechst Ag | PHENOXY-4 PHENOXY-ALKANE-CARBOXYL ACID DERIVATIVES THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
| FI55986C (en) * | 1972-05-10 | 1979-11-12 | Ciba Geigy Ag | FOER ANVAENDNING SOM SKADEDJURS BEKAEMPNINGSMEDEL AVSEDDA SUBSTITUERADE FENYLDERIVAT |
| DE2223894C3 (en) * | 1972-05-17 | 1981-07-23 | Hoechst Ag, 6000 Frankfurt | Herbicidal agents based on phenoxycarboxylic acid derivatives |
| DE2355115A1 (en) * | 1972-11-07 | 1974-05-09 | Erba Carlo Spa | SUBSTITUTED PHENOXYALCANCARBON ACIDS, FUNCTIONAL DERIVATIVES AND SALT THEREOF, AND THE PROCESS FOR THEIR PRODUCTION |
-
1975
- 1975-09-17 CH CH1204875A patent/CH609024A5/en not_active IP Right Cessation
- 1975-09-22 IE IE207075A patent/IE42609B1/en unknown
- 1975-09-23 CA CA236,205A patent/CA1064504A/en not_active Expired
- 1975-09-27 DE DE19752543179 patent/DE2543179A1/en not_active Withdrawn
- 1975-09-27 DE DE19752560602 patent/DE2560602C2/en not_active Expired
- 1975-09-29 NL NL7511452A patent/NL176776C/en not_active IP Right Cessation
- 1975-09-29 DK DK437075A patent/DK146336C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK146336B (en) | 1983-09-12 |
| DE2543179A1 (en) | 1976-04-15 |
| DK437075A (en) | 1976-03-31 |
| NL7511452A (en) | 1976-04-01 |
| DK146336C (en) | 1984-02-20 |
| CH609024A5 (en) | 1979-02-15 |
| IE42609B1 (en) | 1980-09-10 |
| CA1064504A (en) | 1979-10-16 |
| DE2560602C2 (en) | 1986-08-28 |
| NL176776C (en) | 1985-06-03 |
| NL176776B (en) | 1985-01-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE77557T1 (en) | COMPOSITION TO INCREASE INTRACELL ATP LEVELS AND PHYSICAL PERFORMANCE LEVELS AND INCREASE THE RATE OF WOUND HEALING. | |
| DE69421835D1 (en) | The use of erythropoietin for the manufacture of a pharmaceutical preparation for pulmonary administration or inhalation. | |
| GR1001503B (en) | Method for the preparation of pharmaceutical compounds containing carbonic acids containing sulphur and the use thereof in fighting retroviruses. | |
| DE3767408D1 (en) | MEDICINAL PRODUCTS CONTAINING DIPYRIDAMOL OR MOPIDAMOL AND O-ACETYLSALICYL ACID OR THEIR PHYSIOLOGICALLY COMPATIBLE SALTS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR COMBATING THROMBUS FORMATION. | |
| CA2521133A1 (en) | Use of dl-(+/-)-.alpha.-lipoic acid, d-(+)-.alpha.-lipoic acid, .alpha.-lipoic acid in reduced or oxidized form or salts for treating circulatory disorders | |
| ES460098A1 (en) | Derivatives of penicillanic acid | |
| ES431736A1 (en) | PROCEDURE FOR THE PREPARATION OF A DIAGNOSTIC AGENT FOR THE PURPOSE OF CONTROLLING THE COAGULATION CAPACITY OF THE BLOOD. | |
| IE42609L (en) | Diaryl compounds containing sulphur and/or oxygen. | |
| KR890003752A (en) | Use of 2-pyrimidinyl-piperadine derivatives | |
| FR2362849A1 (en) | NEW HETEROCYCLO-OMEGA-PENTANORPROSTAGLANDINS ARYLIC SUBSTITUTES IN POSITION 2 AND MEDICINAL PRODUCTS CONTAINING THEM | |
| ES8701189A1 (en) | S-(carbamoyl-phenylselenyl) derivatives of mercaptans, process for their preparation and pharmaceutical preparations containing them. | |
| PT97279A (en) | METHOD FOR THE PREPARATION OF DERIVATIVES OF NITRATE-ALCANOCARBOXYL ACID ACIDS | |
| AT356109B (en) | METHOD FOR THE PRODUCTION OF NEW 2-ACYL-4-OXO-1,2,3,6,7,11B-HEXAHYDRO-4H-PYRAZINO (2,1-A) ISOCHINOLINE DERIVATIVES, THEIR OPTICAL ANTI-PODES, PHYSIOLOGICALLY SAFE ACID ADDITIONAL SALTS AND QUARTAINE AMMONIUM SALTS | |
| FI891210A0 (en) | THIOSULFINSYRADERIVAT, DERAS ANVAENDNING VID INFLAMMATIONSSJUKDOMAR SAMT LAEKEMEDEL INNEHAOLLANDE DESSA AEMNEN. | |
| IT1197289B (en) | LYSINE SALT OF 4-BIPHENYLACETIC ACID AND ITS OPHTHALMIC COMPOSITIONS | |
| JPS5384943A (en) | New prostaglandin derivative * its preparation and manufactured medicine and veternary drug composition containing it for depression0of formation of stmach acid | |
| ES450866A1 (en) | PROCEDURE FOR THE PREPARATION OF PROSTANE DERIVATIVES. | |
| AT344885B (en) | PROCESS FOR THE PREPARATION OF 18-ARABINOSYL-2-N-BUTYL-3,7,11,15,19,21,23,25,27,37-DEKAHYDROXY-4,16,32,34,36-PENTAMETHYL-TETRACONTA- 16,32-DIEN-35-O-LACTONE-40-GUANIDINIUM SULPHATE (DEBRYCIN) CONTAINING PHARMACEUTICAL PREPARATIONS | |
| GB1421308A (en) | Physiological saline solution | |
| GB1353832A (en) | Sulphonium compounds of alpha-hydroxy-gamma-alkyl-mercapto butyric acid | |
| GB1451389A (en) | Indolobenzazepines | |
| GB1468116A (en) | Esters of 5-n-butyl-pyridine-2-carboxylic acid | |
| GB1467528A (en) | Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate | |
| FR2546168B1 (en) | CYCLIC DITHIODIACETAMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | |
| IL49208A (en) | 13,14-dehydro-16-fluoro prostanoic acid derivatives of the f2,a2 and e2 series,process for their preparation and pharmaceutical compositions containing same |