IE42979L - Pyrazinyl piperazine derivatives - Google Patents
Pyrazinyl piperazine derivativesInfo
- Publication number
- IE42979L IE42979L IE760828A IE82876A IE42979L IE 42979 L IE42979 L IE 42979L IE 760828 A IE760828 A IE 760828A IE 82876 A IE82876 A IE 82876A IE 42979 L IE42979 L IE 42979L
- Authority
- IE
- Ireland
- Prior art keywords
- pyrazinyl
- compounds
- piperazine derivatives
- prepared
- appropriate
- Prior art date
Links
- HCGFLVDMFDHYJD-UHFFFAOYSA-N 2-piperazin-1-ylpyrazine Chemical class C1CNCCN1C1=CN=CC=N1 HCGFLVDMFDHYJD-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000578 anorexic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Novel piperazinylpyrazines of the formula <IMAGE> in which the substituents are defined in Claim 1, and their N-oxides are prepared. These compounds are obtained by reacting an appropriate pyrazine or its N-oxide, which contains an easily removable group in the 2-position, which is defined in Claim 1, with an appropriate piperazine. The compounds III are also prepared as acid addition salts. The compounds obtained can be used in pharmaceutical compositions having anorexic action.
[GB1492528A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57005275A | 1975-04-21 | 1975-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42979L true IE42979L (en) | 1976-10-21 |
| IE42979B1 IE42979B1 (en) | 1980-11-19 |
Family
ID=24277994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE828/76A IE42979B1 (en) | 1975-04-21 | 1976-04-21 | Pyrazinyl piperazine derivatives |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS51136688A (en) |
| AR (1) | AR210349A1 (en) |
| AT (1) | AT353795B (en) |
| AU (1) | AU496854B2 (en) |
| BE (1) | BE840904A (en) |
| BG (1) | BG34185A3 (en) |
| CA (1) | CA1059128A (en) |
| CH (1) | CH619462A5 (en) |
| CS (1) | CS195726B2 (en) |
| CY (1) | CY1090A (en) |
| DD (1) | DD124599A5 (en) |
| DE (1) | DE2617205C3 (en) |
| DK (1) | DK143899C (en) |
| EG (1) | EG12387A (en) |
| ES (4) | ES447150A1 (en) |
| FI (1) | FI62666C (en) |
| FR (1) | FR2308367A1 (en) |
| GB (1) | GB1492528A (en) |
| GR (1) | GR59900B (en) |
| HK (1) | HK60380A (en) |
| HU (1) | HU172684B (en) |
| IE (1) | IE42979B1 (en) |
| IL (1) | IL49391A (en) |
| KE (1) | KE3088A (en) |
| LU (1) | LU74795A1 (en) |
| MY (1) | MY8100225A (en) |
| NL (1) | NL167692C (en) |
| NO (1) | NO146599C (en) |
| PH (1) | PH12274A (en) |
| PL (1) | PL99664B1 (en) |
| PT (1) | PT65027B (en) |
| RO (1) | RO73278A (en) |
| SE (1) | SE421695B (en) |
| SU (1) | SU638260A3 (en) |
| YU (1) | YU100676A (en) |
| ZA (1) | ZA762320B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
| US4163849A (en) | 1978-03-17 | 1979-08-07 | Merck & Co., Inc. | Piperazinylpyrazines |
| US4252816A (en) * | 1979-12-03 | 1981-02-24 | Merck & Co., Inc. | Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents |
| US4339579A (en) | 1980-12-29 | 1982-07-13 | American Home Products Corporation | 2,6-Bis-(pyrrolopyrazinyl)pyrazines |
| EP0094498A3 (en) * | 1982-05-06 | 1985-04-03 | American Cyanamid Company | Antiatherosclerotic 1-piperazine derivatives |
| US4547505A (en) * | 1983-03-25 | 1985-10-15 | Degussa Aktiengesellschaft | N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production |
| US4788290A (en) * | 1987-12-11 | 1988-11-29 | American Home Products Corporation | Serotonergic pyrazine derivatives |
| EP0580465A1 (en) * | 1992-06-25 | 1994-01-26 | Sanofi | New therapeutic use of heterocyclic piperazines as 5-HT3 agonists and new derivatives |
| KR100607838B1 (en) | 1997-10-27 | 2006-08-04 | 뉴로서치 에이/에스 | Homopiperazine Derivatives as Choline Functional Ligands on Nicotine Functional Acetylcholine Receptor and Pharmaceutical Compositions Comprising the Same |
| EP1175416B1 (en) | 1999-04-26 | 2003-07-16 | Neurosearch A/S | Heteroaryl diazacycloalkanes, their preparation and use |
| ATE307121T1 (en) * | 2000-02-16 | 2005-11-15 | Neurogen Corp | SUBSTITUTED ARYLPYRAZINE |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| DK1534391T3 (en) | 2002-07-19 | 2007-06-11 | Biovitrum Ab | New piperazinyl-pyrazinone derivatives for the treatment of 5-HT2A receptor-related disorders |
| SE0202287D0 (en) * | 2002-07-19 | 2002-07-19 | Biovitrum Ab | New compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2606906A (en) * | 1948-10-14 | 1952-08-12 | American Cyanamid Co | 1-(2-pyridyl) piperazine and process of preparing same |
-
1976
- 1976-04-07 EG EG76205A patent/EG12387A/en active
- 1976-04-07 DK DK164476A patent/DK143899C/en not_active IP Right Cessation
- 1976-04-07 SE SE7604093A patent/SE421695B/en not_active IP Right Cessation
- 1976-04-08 NO NO761207A patent/NO146599C/en unknown
- 1976-04-09 NL NL7603800A patent/NL167692C/en not_active IP Right Cessation
- 1976-04-09 FI FI760978A patent/FI62666C/en not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/en unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-13 GR GR50538A patent/GR59900B/en unknown
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/en active Granted
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-15 CY CY1090A patent/CY1090A/en unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/en unknown
- 1976-04-19 JP JP51043763A patent/JPS51136688A/en active Granted
- 1976-04-19 ES ES447150A patent/ES447150A1/en not_active Expired
- 1976-04-20 AT AT288376A patent/AT353795B/en not_active IP Right Cessation
- 1976-04-20 ZA ZA762320A patent/ZA762320B/en unknown
- 1976-04-20 PL PL1976188912A patent/PL99664B1/en unknown
- 1976-04-20 YU YU01006/76A patent/YU100676A/en unknown
- 1976-04-20 SU SU762346054A patent/SU638260A3/en active
- 1976-04-20 AR AR262930A patent/AR210349A1/en active
- 1976-04-20 BG BG032968A patent/BG34185A3/en unknown
- 1976-04-20 DE DE2617205A patent/DE2617205C3/en not_active Expired
- 1976-04-20 BE BE166282A patent/BE840904A/en not_active IP Right Cessation
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 CH CH492676A patent/CH619462A5/en not_active IP Right Cessation
- 1976-04-20 RO RO7685688A patent/RO73278A/en unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/en unknown
- 1976-04-21 PT PT65027A patent/PT65027B/en unknown
-
1977
- 1977-06-01 ES ES459406A patent/ES459406A1/en not_active Expired
- 1977-06-01 ES ES459407A patent/ES459407A1/en not_active Expired
- 1977-06-01 ES ES459405A patent/ES459405A1/en not_active Expired
-
1980
- 1980-10-02 KE KE3088A patent/KE3088A/en unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/en unknown
-
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/en unknown
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