IE43119L - Benzophenones - Google Patents
BenzophenonesInfo
- Publication number
- IE43119L IE43119L IE761292A IE129276A IE43119L IE 43119 L IE43119 L IE 43119L IE 761292 A IE761292 A IE 761292A IE 129276 A IE129276 A IE 129276A IE 43119 L IE43119 L IE 43119L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- prepared
- compounds
- june
- phenols
- Prior art date
Links
- 239000012965 benzophenone Substances 0.000 title 1
- 150000008366 benzophenones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002989 phenols Chemical class 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 238000005618 Fries rearrangement reaction Methods 0.000 abstract 1
- BZMNSNYAKYIRCL-UHFFFAOYSA-N [2-(3-amino-2-hydroxypropoxy)phenyl]-phenylmethanone Chemical class C(C1=CC=CC=C1)(=O)C1=C(OCC(CN)O)C=CC=C1 BZMNSNYAKYIRCL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
- C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1495680 1 - (2 - Benzoylphenoxy) - 2 - hydroxy-3-aminopropanes MAY & BAKER Ltd 16 June 1976 [20 June 1975] 26407/75 Heading C2C Novel compounds of Formula I (wherein R<SP>1</SP> represents an isopropyl, t-butyl or 2-phenylethyl group, R<SP>2</SP> represents a methyl group or a chlorine atom, n represents 1 or 2 and m represents 0, 1 or 2) and non-toxic acid addition salts thereof where it is to be understood that when m represents 2 then the substitutents represented by the symbol R<SP>2</SP> may be the same or different are prepared by reaction of a compound of Formula II with an amine R<SP>1</SP>NH 2 . Intermediates of Formula II above are prepared from compounds of Formula IV with epichlorohydrin. Phenols of Formula IV are prepared by Fries rearrangement of the substituted benzoyloxy compounds prepared by acylation of the unsubstituted phenols. Pharmaceutical compositions in conventional forms for oral or parenteral administration and having vascular #-andrenoceptor blocking activity comprise an above novel compound and a carrier or diluent.
[GB1495680A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB26407/75A GB1495680A (en) | 1975-06-20 | 1975-06-20 | 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43119L true IE43119L (en) | 1976-12-20 |
| IE43119B1 IE43119B1 (en) | 1980-12-17 |
Family
ID=10243171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1292/76A IE43119B1 (en) | 1975-06-20 | 1976-06-15 | 1-(2-benzoylphenoxy)-2-hydroxy-3-aminopropanes |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS525749A (en) |
| AU (1) | AU503182B2 (en) |
| BE (1) | BE843170A (en) |
| CH (1) | CH601186A5 (en) |
| DE (1) | DE2627210A1 (en) |
| DK (1) | DK145041C (en) |
| FR (1) | FR2314711A1 (en) |
| GB (1) | GB1495680A (en) |
| IE (1) | IE43119B1 (en) |
| LU (1) | LU75199A1 (en) |
| NL (1) | NL7606354A (en) |
| SE (1) | SE426237B (en) |
| ZA (1) | ZA763514B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1147311B (en) * | 1980-02-13 | 1986-11-19 | Stabil Bioterapico Farmachim | BASIC ETHERS OF 4-HYDROXY-BENZOFENONES WITH ACTIVITIES SUCH AS BETABLOCCANT AGENTS AND RELATED PREPARATION PROCEDURE |
| SE9101509D0 (en) * | 1991-05-17 | 1991-05-17 | Karobio Ab | RECEPTOR LIGANDS |
-
1975
- 1975-06-20 GB GB26407/75A patent/GB1495680A/en not_active Expired
-
1976
- 1976-06-11 DK DK262776A patent/DK145041C/en not_active IP Right Cessation
- 1976-06-11 SE SE7606707A patent/SE426237B/en unknown
- 1976-06-11 NL NL7606354A patent/NL7606354A/en not_active Application Discontinuation
- 1976-06-14 JP JP51068826A patent/JPS525749A/en active Pending
- 1976-06-14 ZA ZA763514A patent/ZA763514B/en unknown
- 1976-06-15 IE IE1292/76A patent/IE43119B1/en unknown
- 1976-06-15 AU AU14910/76A patent/AU503182B2/en not_active Expired
- 1976-06-16 FR FR7618231A patent/FR2314711A1/en active Granted
- 1976-06-18 DE DE19762627210 patent/DE2627210A1/en not_active Ceased
- 1976-06-18 CH CH783576A patent/CH601186A5/xx not_active IP Right Cessation
- 1976-06-18 LU LU75199A patent/LU75199A1/xx unknown
- 1976-06-18 BE BE168117A patent/BE843170A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK145041C (en) | 1983-01-10 |
| FR2314711B1 (en) | 1978-12-15 |
| SE7606707L (en) | 1976-12-21 |
| GB1495680A (en) | 1977-12-21 |
| AU1491076A (en) | 1977-12-22 |
| NL7606354A (en) | 1976-12-22 |
| BE843170A (en) | 1976-12-20 |
| DE2627210A1 (en) | 1976-12-30 |
| DK262776A (en) | 1976-12-21 |
| AU503182B2 (en) | 1979-08-23 |
| FR2314711A1 (en) | 1977-01-14 |
| JPS525749A (en) | 1977-01-17 |
| ZA763514B (en) | 1977-05-25 |
| SE426237B (en) | 1982-12-20 |
| IE43119B1 (en) | 1980-12-17 |
| DK145041B (en) | 1982-08-09 |
| LU75199A1 (en) | 1977-03-15 |
| CH601186A5 (en) | 1978-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE44055L (en) | Phthalanes | |
| IE780515L (en) | Morphine derivatives | |
| GB1488692A (en) | Pyrazolo(3,4,6)quinolines | |
| GB1513320A (en) | N-propargyl-2-phenylamino-2-imidazolines | |
| IE36116B1 (en) | Furylmethyl morphinane derivatives and pharmaceutical compositions containing them | |
| GB1481813A (en) | Substituted thiazolinylidenyl ketones and their pharmaceutical compositions | |
| IE43119L (en) | Benzophenones | |
| GB1490486A (en) | 4-imino-1,3-diazobicyclo-(3.1.0)hexan-2-one | |
| IE33760L (en) | Morpholine derivatives | |
| IE780514L (en) | Morphine derivatives | |
| GB1436307A (en) | Diaromatic o-aminoalkyl-oximes | |
| GB1230219A (en) | ||
| GB1464259A (en) | Imidazo-thiazole and -thiadiazole sulphonamides and their use as therapeutic agents | |
| GB1473971A (en) | 3-hydroxy-5,6-benzomorphinan derivatives | |
| GB1245549A (en) | (thienylideneamino)oxy-alkanoic acid and derivatives thereof | |
| IE35223L (en) | Bis-basic ethers of 2, 6- and 2, 7-dihydroxy-anthraquinones | |
| GB1361863A (en) | Piperazine derivatives their preparation and pharmaceutical compositions containing them | |
| GB1322069A (en) | Aminoalkanoylaminocyclohexane derivatives | |
| GB1464431A (en) | Indolobenzazepine derivatives and a process for the manufacture thereof | |
| GB1501149A (en) | Isocarbostyril derivatives | |
| GB1425729A (en) | 1,4-dihydropyridine compounds | |
| GB1219387A (en) | Bicyclo[2.2.2]oct-2-ene-amino acid compounds | |
| GB1116308A (en) | Novels-triazolo[3,4-a]isoquinolines and the preparation thereof | |
| GB1472344A (en) | Methylene dibenzocycloheptanes | |
| GB1470743A (en) | Cyclopropylmethylamine derivatives |