IE43198L - Prostanoic acid derivatives - Google Patents
Prostanoic acid derivativesInfo
- Publication number
- IE43198L IE43198L IE751550A IE155075A IE43198L IE 43198 L IE43198 L IE 43198L IE 751550 A IE751550 A IE 751550A IE 155075 A IE155075 A IE 155075A IE 43198 L IE43198 L IE 43198L
- Authority
- IE
- Ireland
- Prior art keywords
- alkoxy
- vinylene
- alkylidene
- pharmaceutically
- compounds
- Prior art date
Links
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 2
- 239000005977 Ethylene Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- 208000009079 Bronchial Spasm Diseases 0.000 abstract 1
- 208000014181 Bronchial disease Diseases 0.000 abstract 1
- 206010006482 Bronchospasm Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- -1 carboxy hydroxymethyl Chemical group 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 229960004407 chorionic gonadotrophin Drugs 0.000 abstract 1
- 229940124558 contraceptive agent Drugs 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000012173 estrus Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000002863 oxytocic agent Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 229960004509 serum gonadotrophin Drugs 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940125711 uterine stimulant agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1486832 Compositions containing prostaglandins IMPERIAL CHEMICAL INDUSTRIES Ltd 7 July 1975 [5 Aug 1974] 34334/74 Heading A5B [Also in Divisions C2 and C3] Pharmaceutically and veterinary compositions in a form suitable for oral, parenteral, rectal, vaginal administration or for inhalation, contain prostaglandins of the formula I wherein either R' is carboxy hydroxymethyl or (C 1-10 alkoxy) carbonyl, R<SP>4</SP> is OH and R<SP>5</SP> is H 1 or R<SP>1</SP> is carboxy or (C 1-10 alkoxy) carbonyl and R<SP>4</SP> and R<SP>5</SP> together form an oxo radical; R<SP>2</SP> is OH or C 1-4 alkoxy; Y is ethylene or trans-vinylene, either A is ethylene or vinylene and X is C 1-6 alkylidene-oxy wherein the alkylidene is bonded to CHR and the oxygen is bonded to R<SP>3</SP>, or C 1-6 alkylidene, or A is vinylene and X is a direct bond; and R<SP>3</SP> is phenyl or naphthyl optionally substituted by one or two halogen atoms, NO2, OH, CF 3 , phenyl, C 1-5 alkyl, di(C 1-5 alkyl) amino, C 2-5 alkenyl or C 1-5 alkoxy radicals, or for these compounds wherein R' is carboxy the pharmaceutically or veterinary acceptable salts thereof together with pharmaceutically or veterinarily acceptable diluents or carriers. The compounds may be used in combination, or concurrently with uterine stimulants, for example, oxytosin, or gonadotrophins, for example pregnant mare serum gonadotrophin or human chorionic gonadotrophin. The compounds are used in the induction of labour, the control of the oestrus cycle, as contraceptives, as hypotensives, for the relief of bronchospasm, or as inhibitors of gastric secretion or blood platelet aggregation.
[GB1486832A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB34334/74A GB1486832A (en) | 1974-08-05 | 1974-08-05 | Prostanoic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43198L true IE43198L (en) | 1976-02-05 |
| IE43198B1 IE43198B1 (en) | 1981-01-14 |
Family
ID=10364354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1550/75A IE43198B1 (en) | 1974-08-05 | 1975-07-11 | Prostanoic acid derivatives |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS51125042A (en) |
| AT (1) | ATA606175A (en) |
| AU (1) | AU502146B2 (en) |
| BE (1) | BE832098A (en) |
| CA (1) | CA1067490A (en) |
| DD (1) | DD124595A5 (en) |
| DE (1) | DE2534989A1 (en) |
| DK (1) | DK354575A (en) |
| FI (1) | FI752196A7 (en) |
| FR (1) | FR2281101A1 (en) |
| GB (1) | GB1486832A (en) |
| IE (1) | IE43198B1 (en) |
| IN (1) | IN141386B (en) |
| NL (1) | NL7509078A (en) |
| NO (1) | NO752734L (en) |
| SE (1) | SE7508779L (en) |
| ZA (1) | ZA754491B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1554030A (en) * | 1976-05-10 | 1979-10-17 | Upjohn Co | Prostaglandins |
| GB8625325D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
| US5688819A (en) * | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US6184250B1 (en) | 1993-08-03 | 2001-02-06 | Alcon Laboratories, Inc. | Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension |
| US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| WO2025149165A1 (en) * | 2024-01-12 | 2025-07-17 | Intervet International B.V. | A PROCESS FOR PURIFICATION OF INTERMEDIATES OF PROSTAGLANDIN F2Αα COMPOUNDS AND ITS USE IN THE PREPARATION OF PROSTAGLANDIN F2α COMPOUNDS |
-
1974
- 1974-08-05 GB GB34334/74A patent/GB1486832A/en not_active Expired
-
1975
- 1975-07-11 IE IE1550/75A patent/IE43198B1/en unknown
- 1975-07-14 ZA ZA00754491A patent/ZA754491B/en unknown
- 1975-07-15 CA CA231,547A patent/CA1067490A/en not_active Expired
- 1975-07-16 AU AU83102/75A patent/AU502146B2/en not_active Expired
- 1975-07-16 IN IN1391/CAL/75A patent/IN141386B/en unknown
- 1975-07-30 NL NL7509078A patent/NL7509078A/en not_active Application Discontinuation
- 1975-07-31 FI FI752196A patent/FI752196A7/fi not_active Application Discontinuation
- 1975-08-04 SE SE7508779A patent/SE7508779L/en unknown
- 1975-08-04 FR FR7524249A patent/FR2281101A1/en active Granted
- 1975-08-04 NO NO752734A patent/NO752734L/no unknown
- 1975-08-04 BE BE158923A patent/BE832098A/en unknown
- 1975-08-05 AT AT606175A patent/ATA606175A/en not_active Application Discontinuation
- 1975-08-05 DD DD187691A patent/DD124595A5/xx unknown
- 1975-08-05 JP JP50095328A patent/JPS51125042A/en active Pending
- 1975-08-05 DK DK354575A patent/DK354575A/en not_active Application Discontinuation
- 1975-08-05 DE DE19752534989 patent/DE2534989A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS51125042A (en) | 1976-11-01 |
| DD124595A5 (en) | 1977-03-02 |
| FR2281101A1 (en) | 1976-03-05 |
| NO752734L (en) | 1976-02-06 |
| GB1486832A (en) | 1977-09-28 |
| DE2534989A1 (en) | 1976-02-26 |
| BE832098A (en) | 1976-02-04 |
| IE43198B1 (en) | 1981-01-14 |
| FR2281101B1 (en) | 1978-11-10 |
| ATA606175A (en) | 1978-05-15 |
| CA1067490A (en) | 1979-12-04 |
| NL7509078A (en) | 1976-02-09 |
| AU8310275A (en) | 1977-01-20 |
| ZA754491B (en) | 1976-06-30 |
| IN141386B (en) | 1977-02-19 |
| AU502146B2 (en) | 1979-07-12 |
| DK354575A (en) | 1976-02-06 |
| SE7508779L (en) | 1976-02-06 |
| FI752196A7 (en) | 1976-02-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1432576A (en) | Substituted phenylacetic acids | |
| GB1454778A (en) | Therapeutic compositions comprising dioxamates | |
| ES8302001A1 (en) | Cephalosporin derivatives, a process for their preparation and compositions containing them. | |
| GB1486832A (en) | Prostanoic acid derivatives | |
| EP0128007A3 (en) | Phenyl tetrahydronaphthylcarboxylate derivatives | |
| GB1458315A (en) | Prostanoic acid derivatives | |
| GB1343827A (en) | Acylaminotetrazoles and process for preparing them | |
| GB1308028A (en) | Thiazolylbenzoic acid derivatives and a process for their manufactur | |
| SE7504150L (en) | PROSTAGLANDIN COMPOSITIONS | |
| SE7310986L (en) | PROCEDURE FOR PREPARING THE SUBJECT LEMPLIGA SASOM TOYS. | |
| GB1506816A (en) | Prostaglandins | |
| GB1421006A (en) | Imidazolidine derivatives | |
| IE40501B1 (en) | Alkyl derivatives of prostanoic acids and preparation thereof | |
| GB1443692A (en) | 1,2-diphenylethanolamine derivatives and their salts and the preparation thereof | |
| GB1347930A (en) | Imidazolines and a proces for the preparation thereof | |
| GB1508168A (en) | 11-deoxy-15-substituted-16,17,18,19,20-pentanorprostaglandins | |
| GB1397434A (en) | Evomonoside derivatives | |
| GB1345214A (en) | Isoxazoles | |
| GB1530848A (en) | 2-(phenylalkylhydrazono)-propionic acid derivatives | |
| GB1264944A (en) | ||
| GB1202010A (en) | Prostaglandins and the manufacture thereof | |
| GB1464206A (en) | ||
| GB1438093A (en) | Prostaglandins and the manufacture thereof | |
| GB1436831A (en) | Prostaglandins and the preparation thereof | |
| GB1509781A (en) | Prostaglandin analogues |