IE43210L - Adenosine nitrates - Google Patents
Adenosine nitratesInfo
- Publication number
- IE43210L IE43210L IE760267A IE26776A IE43210L IE 43210 L IE43210 L IE 43210L IE 760267 A IE760267 A IE 760267A IE 26776 A IE26776 A IE 26776A IE 43210 L IE43210 L IE 43210L
- Authority
- IE
- Ireland
- Prior art keywords
- amino
- nitrates
- adenosine
- feb
- ethyl
- Prior art date
Links
- -1 Adenosine nitrates Chemical class 0.000 title abstract 5
- OIRDTQYFTABQOQ-KQYNXXCUSA-N Adenosine Natural products C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title abstract 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 title abstract 2
- 229960005305 adenosine Drugs 0.000 title abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical class C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000000802 nitrating effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
1489327 Adenosine nitrates F HOFFMANNLA ROCHE & CO AG 17 Feb 1976 [18 Feb 1975 4 July 1975] 06162/76 Heading C2C Novel compounds I and their acid addition salts in which R<SP>1</SP> and R<SP>2</SP> are H or NO 2 and at least one is NO 2 , and R<SP>5</SP> is OH, C 1-6 alkoxy, amino optionally mono- or di-C 1-6 alkylated, aryl- C 1-6 alkylamino, [2 - (dimethylamino)ethyl]- amino, [2- (2,4 - dinitrophenyl) - ethyl]amino or (2 - nitrooxyethyl)amino, cycloalkylamino or an N-containing heterocyclic ring bonded via an N-atom are prepared by nitrating a compound II Compounds I affect the heart and circulatory dynamics and form with a carrier a pharmaceutical composition which may be administered orally or parenterally.
[GB1489327A]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH203275A CH606084A5 (en) | 1975-02-18 | 1975-02-18 | (Di) nitrates of adenosine -5'-carboxylic acid derivs |
| CH874875 | 1975-07-04 | ||
| CH1609475A CH612948A5 (en) | 1975-12-11 | 1975-12-11 | Process for the preparation of adenosine nitrates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43210L true IE43210L (en) | 1976-08-18 |
| IE43210B1 IE43210B1 (en) | 1981-01-14 |
Family
ID=27173417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE267/76A IE43210B1 (en) | 1975-02-18 | 1976-02-11 | Nitrates of adenosine-5'-carboxylic acid derivatives, process for their manufacture, and pharmaceutical preparations containing them |
Country Status (23)
| Country | Link |
|---|---|
| JP (1) | JPS51105095A (en) |
| AR (1) | AR217398A1 (en) |
| AU (1) | AU497075B2 (en) |
| BR (1) | BR7600997A (en) |
| CA (1) | CA1050534A (en) |
| DD (1) | DD124252A5 (en) |
| DE (1) | DE2606532A1 (en) |
| DK (1) | DK136957B (en) |
| ES (1) | ES445234A1 (en) |
| FI (1) | FI61194C (en) |
| FR (1) | FR2301264A1 (en) |
| GB (1) | GB1489327A (en) |
| GR (1) | GR59304B (en) |
| HU (1) | HU172959B (en) |
| IE (1) | IE43210B1 (en) |
| IL (1) | IL48854A (en) |
| LU (1) | LU74356A1 (en) |
| NL (1) | NL7600663A (en) |
| NO (1) | NO141652C (en) |
| NZ (1) | NZ179785A (en) |
| PH (1) | PH15859A (en) |
| PT (1) | PT64811B (en) |
| SE (1) | SE423237B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5310731A (en) * | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
| EP2876166B1 (en) | 2013-11-20 | 2016-12-14 | Roche Diagnostics GmbH | New compound for sequencing by synthesis |
-
1976
- 1976-01-16 IL IL48854A patent/IL48854A/en unknown
- 1976-01-20 AU AU10428/76A patent/AU497075B2/en not_active Expired
- 1976-01-20 NZ NZ179785A patent/NZ179785A/en unknown
- 1976-01-22 NL NL7600663A patent/NL7600663A/en not_active Application Discontinuation
- 1976-01-27 FI FI760184A patent/FI61194C/en not_active IP Right Cessation
- 1976-02-04 CA CA245,008A patent/CA1050534A/en not_active Expired
- 1976-02-11 IE IE267/76A patent/IE43210B1/en unknown
- 1976-02-11 HU HU76HO00001875A patent/HU172959B/en unknown
- 1976-02-13 PH PH18105A patent/PH15859A/en unknown
- 1976-02-16 SE SE7601725A patent/SE423237B/en unknown
- 1976-02-16 GR GR50064A patent/GR59304B/en unknown
- 1976-02-16 JP JP51014997A patent/JPS51105095A/ja active Pending
- 1976-02-16 FR FR7604163A patent/FR2301264A1/en active Granted
- 1976-02-16 LU LU74356A patent/LU74356A1/xx unknown
- 1976-02-17 DK DK62776AA patent/DK136957B/en not_active IP Right Cessation
- 1976-02-17 NO NO760520A patent/NO141652C/en unknown
- 1976-02-17 PT PT64811A patent/PT64811B/en unknown
- 1976-02-17 ES ES445234A patent/ES445234A1/en not_active Expired
- 1976-02-17 GB GB6162/76A patent/GB1489327A/en not_active Expired
- 1976-02-17 DD DD191276A patent/DD124252A5/en unknown
- 1976-02-17 BR BR7600997A patent/BR7600997A/en unknown
- 1976-02-18 DE DE19762606532 patent/DE2606532A1/en not_active Withdrawn
- 1976-03-05 AR AR262163A patent/AR217398A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| AR217398A1 (en) | 1980-03-31 |
| BR7600997A (en) | 1976-09-14 |
| FI61194B (en) | 1982-02-26 |
| HU172959B (en) | 1979-01-28 |
| NO141652C (en) | 1980-04-16 |
| PH15859A (en) | 1983-04-13 |
| IE43210B1 (en) | 1981-01-14 |
| DD124252A5 (en) | 1977-02-09 |
| DK62776A (en) | 1976-08-19 |
| PT64811B (en) | 1978-02-06 |
| NZ179785A (en) | 1978-04-28 |
| LU74356A1 (en) | 1977-09-12 |
| NO141652B (en) | 1980-01-07 |
| CA1050534A (en) | 1979-03-13 |
| IL48854A0 (en) | 1976-03-31 |
| DK136957C (en) | 1978-05-29 |
| IL48854A (en) | 1979-12-30 |
| SE7601725L (en) | 1976-08-19 |
| NL7600663A (en) | 1976-08-20 |
| GR59304B (en) | 1977-12-12 |
| NO760520L (en) | 1976-08-19 |
| SE423237B (en) | 1982-04-26 |
| FR2301264A1 (en) | 1976-09-17 |
| ES445234A1 (en) | 1977-06-01 |
| FI760184A7 (en) | 1976-08-19 |
| AU1042876A (en) | 1977-07-28 |
| PT64811A (en) | 1976-03-01 |
| DK136957B (en) | 1977-12-19 |
| FR2301264B1 (en) | 1980-06-20 |
| GB1489327A (en) | 1977-10-19 |
| DE2606532A1 (en) | 1976-08-26 |
| JPS51105095A (en) | 1976-09-17 |
| FI61194C (en) | 1982-06-10 |
| AU497075B2 (en) | 1978-11-23 |
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