IE43267L - Imidazole derivatives - Google Patents
Imidazole derivativesInfo
- Publication number
- IE43267L IE43267L IE752061A IE206175A IE43267L IE 43267 L IE43267 L IE 43267L IE 752061 A IE752061 A IE 752061A IE 206175 A IE206175 A IE 206175A IE 43267 L IE43267 L IE 43267L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- compound
- compounds
- reacted
- image
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title abstract 2
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 9
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The novel imidazole derivatives correspond to the formula <IMAGE> in which R, R<1> and p have the meanings given in Patent Claim 1, and m is 0, 1 or 2. To prepare the compounds of formula I, wherein m is 0, a compound of formula: <IMAGE> is reacted with a compound of formula RSH. X denotes a group which can be split off. To prepare compounds of formula I, wherein m represents 1 or 2, a) a compound of formula II is reacted with a compound of formula RSH and b) the resulting compound of formula I, wherein m represents O, is oxidised. m conforms to the conditions specified for q in Patent Claim 7. The compounds of formula I are obtained in the form of their free base or of its acid addition salts. These can be converted into one another. An agent for inhibiting the growth of fungi or bacteria in plants or in agricultural or industrial products contains a compound of formula I as active ingredient, mixed with a carrier. The compounds of formula I possess, quite generally, an antifungal and antibacterial action and can also be used for pharmaceutical purposes.
[GB1485719A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50838474A | 1974-09-23 | 1974-09-23 | |
| US59362075A | 1975-07-07 | 1975-07-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE43267L true IE43267L (en) | 1976-03-23 |
| IE43267B1 IE43267B1 (en) | 1981-01-28 |
Family
ID=27056177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2061/75A IE43267B1 (en) | 1974-09-23 | 1975-09-19 | 1-/ -(r-thio)phenethyl/imidazoles and derivatives thereof |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5910344B2 (en) |
| AR (1) | AR224222A1 (en) |
| AU (1) | AU496881B2 (en) |
| CA (1) | CA1064040A (en) |
| CH (1) | CH623813A5 (en) |
| DE (1) | DE2541833A1 (en) |
| DK (1) | DK155283C (en) |
| FI (1) | FI64583C (en) |
| FR (1) | FR2285126A1 (en) |
| GB (1) | GB1485719A (en) |
| HK (1) | HK8380A (en) |
| IE (1) | IE43267B1 (en) |
| IL (1) | IL47885A (en) |
| MX (1) | MX4832E (en) |
| MY (1) | MY8000270A (en) |
| NL (1) | NL174462C (en) |
| NO (1) | NO144345C (en) |
| SE (1) | SE428471B (en) |
| YU (3) | YU39746B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA755100B (en) * | 1974-09-23 | 1977-03-30 | Syntex Inc | 1-(b-(r-thio) phenethyl) imidazoles and derivatives thereof |
| EP0013786B1 (en) * | 1979-01-22 | 1982-10-06 | Syntex (U.S.A.) Inc. | Imidazole derivatives, pharmaceutical compositions containing them and their preparation |
| JPS63156228U (en) * | 1987-04-01 | 1988-10-13 | ||
| DE3939525A1 (en) * | 1989-11-30 | 1991-06-06 | Hoechst Ag | ARYL-ALKYL-AZOLES SUBSTITUTED WITH MULTIPLE UNSATURATED REMAINS, METHOD FOR THEIR PRODUCTION AND THEIR USE |
| IT1303672B1 (en) * | 1998-07-28 | 2001-02-23 | Nicox Sa | NITRATED SALTS OF DRUGS ACTIVE IN BONE DISORDERS |
| CN116063234B (en) * | 2022-12-29 | 2023-11-24 | 山东京卫制药有限公司 | Preparation method of sulconazole nitrate |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU557755A3 (en) * | 1968-08-19 | 1977-05-05 | Янссен Фармасьютика Н.В. (Фирма) | Method for preparing imidazole derivatives |
| US3658813A (en) * | 1970-01-13 | 1972-04-25 | Janssen Pharmaceutica Nv | 1-(beta-aryl-beta-(r-oxy)-ethyl)-imidazoles |
| DE2041771C3 (en) * | 1970-08-22 | 1979-07-26 | Bayer Ag, 5090 Leverkusen | derivatives |
| SE364275B (en) * | 1971-06-17 | 1974-02-18 | Janssen Pharmaceutica Nv | |
| DE2242454A1 (en) * | 1972-08-29 | 1974-03-07 | Bayer Ag | 1-AETHYL-IMIDAZOLE, METHOD FOR MANUFACTURING IT AND ITS USE AS A MEDICINAL PRODUCT |
-
1975
- 1975-08-06 IL IL47885A patent/IL47885A/en unknown
- 1975-08-18 CA CA233,620A patent/CA1064040A/en not_active Expired
- 1975-08-19 AU AU84081/75A patent/AU496881B2/en not_active Expired
- 1975-08-20 MX MX755341U patent/MX4832E/en unknown
- 1975-08-28 GB GB35569/75A patent/GB1485719A/en not_active Expired
- 1975-08-29 NL NLAANVRAGE7510224,A patent/NL174462C/en not_active IP Right Cessation
- 1975-09-03 AR AR260311A patent/AR224222A1/en active
- 1975-09-05 YU YU2244/75A patent/YU39746B/en unknown
- 1975-09-05 NO NO753048A patent/NO144345C/en unknown
- 1975-09-19 JP JP50113538A patent/JPS5910344B2/en not_active Expired
- 1975-09-19 IE IE2061/75A patent/IE43267B1/en unknown
- 1975-09-19 FI FI752614A patent/FI64583C/en not_active IP Right Cessation
- 1975-09-19 DE DE19752541833 patent/DE2541833A1/en active Granted
- 1975-09-22 SE SE7510595A patent/SE428471B/en not_active IP Right Cessation
- 1975-09-22 FR FR7529009A patent/FR2285126A1/en active Granted
- 1975-09-22 CH CH1225575A patent/CH623813A5/en not_active IP Right Cessation
- 1975-09-23 DK DK427075A patent/DK155283C/en active
-
1980
- 1980-03-06 HK HK83/80A patent/HK8380A/en unknown
- 1980-12-31 MY MY1980270A patent/MY8000270A/en unknown
-
1981
- 1981-09-21 YU YU02269/81A patent/YU226981A/en unknown
- 1981-09-21 YU YU02270/81A patent/YU227081A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI752614A7 (en) | 1976-03-24 |
| FR2285126B1 (en) | 1979-09-14 |
| JPS5157828A (en) | 1976-05-20 |
| YU226981A (en) | 1982-02-28 |
| NL174462B (en) | 1984-01-16 |
| NO144345C (en) | 1981-08-12 |
| DE2541833C2 (en) | 1989-09-14 |
| IL47885A (en) | 1979-01-31 |
| NO753048L (en) | 1976-03-24 |
| CA1064040A (en) | 1979-10-09 |
| DK427075A (en) | 1976-03-24 |
| YU224475A (en) | 1982-02-28 |
| HK8380A (en) | 1980-03-14 |
| MY8000270A (en) | 1980-12-31 |
| IL47885A0 (en) | 1975-11-25 |
| AU496881B2 (en) | 1978-11-09 |
| NL174462C (en) | 1984-06-18 |
| NO144345B (en) | 1981-05-04 |
| AR224222A1 (en) | 1981-11-13 |
| JPS5910344B2 (en) | 1984-03-08 |
| MX4832E (en) | 1982-10-26 |
| DK155283C (en) | 1989-07-24 |
| FI64583B (en) | 1983-08-31 |
| YU39746B (en) | 1985-04-30 |
| CH623813A5 (en) | 1981-06-30 |
| FI64583C (en) | 1983-12-12 |
| NL7510224A (en) | 1976-03-25 |
| AU8408175A (en) | 1977-02-24 |
| SE428471B (en) | 1983-07-04 |
| GB1485719A (en) | 1977-09-14 |
| FR2285126A1 (en) | 1976-04-16 |
| DE2541833A1 (en) | 1976-04-01 |
| IE43267B1 (en) | 1981-01-28 |
| DK155283B (en) | 1989-03-20 |
| SE7510595L (en) | 1976-03-24 |
| YU227081A (en) | 1982-02-28 |
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